Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"PDH"”.
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Phosphorylation of Skeletal Muscle Pyruvate Dehydrogenase Phosphatase in Response to Insulin Stimulation
… oxidation through the pyruvate dehydrogenase (PDH) complex. PDP activates PDH, enabling increased carbohydrate flux towards oxidative energy production. In culture myoblasts, both PDP1 and PDP2 undergo covalent activation in response to insulin–stimulation by protein kinase C delta (PKCδ). Our …
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The Role of Pyruvate Dehydrogenase in Cell Growth
… indicating activity of pyruvate dehydrognase (PDH), which gates entry of glucose derived carbon into the tricarboxylic acid (TCA) cycle. To test whether cells require glucose oxidation for proliferation, the work in this thesis establishes a model wherein PDH activity is suppressed using RNA …
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Regulation of mitochondrial respiration by LDHB suppression in hepatoma cell lines
… Thus, we focused on pyruvate dehydrogenase (PDH) which is a key regulatory enzyme linking glycolysis and mitochondrial activity by controlling TCA cycle. Interestingly, LDHB knockdown effectively increased phosphorylation of PDH, indicating its inactivation. Treatment of lactate without LDHB …
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Isolation and characterization of the (NAD(P)-independent)polyol dehydrogenase from the plasma-membranes of gluconobacter oxydans ATCC strain 621
… that this enzyme is a polyol dehydrogenase (PDH). The isolated PDH complex showed optimal sorbitol oxidation from pH 5 to 6 at 40°C, and contained pyrroloquinoline quinone (PQQ) as its prosthetic group. Apo-PDH could be created by salt treatment and the holoenzyme reconstituted with authentic …
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Adaptations of skeletal muscle pyruvate dehydrogenase kinase in response to food-restriction in mitochondrial subpopulations
… Dr. Sandra J. Peters Pyruvate dehydrogenase (PDH) catalyses the decarboxylation of pyruvate, to form acetyl-CoA. PDH activity is down-regulated by intrinsic PDH kinases (predominantly PDK2 and PDK4 isoforms), but the understanding of the PDK isoform distribution and adaptation to nutritional …
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Pyruvate dehydrogenase activity in response to skeletal muscle contraction at two stimulation frequencies in pyruvate dehydrogenase kinase 2 knockout mice
Pyruvate dehydrogenase (PDH) plays an important role in regulating carbohydrate oxidation in skeletal muscle. PD H is deactivated by a set of PD H kinases (PD K 1-4) with PDK2 and 4 being the predominant isoforms in skeletal muscle. PDK2 is highly sensitive to pyruvate inhibition, and is the most …
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The acute effects of differential dietary fatty acids on PDHa activity in human skeletal muscle at the onset of exercise
Pyruvate dehydrogenase (PDH) is an important regulator of carbohydrate oxidation during exercise and its activity can be down-regulated by an increase in dietary fat. The purpose of this study was to determine the acute metabolic effects of differential dietary fatty acids on the activation of PDH …
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The Role of Metabolic Inflexibility in Heart Failure
… progression to HF. Since pyruvate dehydrogenase (PDH) kinase 4 (PDK4) is the predominant PDK found in the heart and PDK4 expression in the heart increases with high circulating fat levels, I employed a genetic approach to modulate its expression in cardiomyocytes specifically. This animal model …
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DEVELOPMENT OF NOVEL CATALYSTS AND PROCESSES FOR SUSTAINABLE HYDROGEN TECHNOLOGIES
… on key reactions like propane dehydrogenation (PDH), CO₂ methanation, dry reforming of methane (DRM), and COₓ-free catalytic methane decomposition (CDM). A core challenge in these processes is catalyst sintering, which reduces stability and performance. The research develops anti-sintering …
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Survival Strategies of Streptococcus mutans during Carbohydrate Starvation
… encode components of the pyruvate dehydrogenase (PDH) complex. Northern Blot analysis showed that pdhD and the downstream genes, pdhA, pdhB and pdhC, form an operon that is transcribed predominantly in stationary phase. Inactivation of pdhD impaired survival of both batch cultures and biofilms. …
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Studies on lipoic acid metabolism
… metabolism enzymes pyruvate dehydrogenase (PDH) and oxoglutarate dehydrogenase (OGDH) is essential for their activation and thus for respiratory growth in the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae. A third lipoic acid-dependent enzyme system, the glycine cleavage …
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Lipoic acid metabolism in Leishmania major
… alpha-KADHs include the pyruvate dehydrogenase (PDH), branched-chain alpha-ketoacid dehydrogenase (BCKDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH), each of which is integral to cellular energy metabolism. In some organisms, LA can be acquired through salvage and biosynthesis pathways, …
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Quantitative proteomic analysis of cellular senescence: from systems biology to targeted signaling pathways
… by the regulation of pyruvate dehydrogenase (PDH) activity. Data consistent with this hypothesis was collected in OIS as both the inactive form of PDH and the cognate kinase (PDK-1) that turns it off decreased. Increased activity of PDH drove an increased flux of pyruvate into the TCA cycle …
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Monte-Carlo Simulation of Diffusion as an Aid to Interpreting Quasi-elastic Neutron Scattering from Lattice Gas Systems with Diffusion on Multiple Time-Scales
… mentation. Historical QENS measurements of PdH have been interpreted in terms of single process involving nearest-neighbour jumps between octahedral sites in the fcc lattice. The observation of an additional QENS component arising from motion on significantly more rapid timescale has …
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Implementation of side-fringe locking in an SHG cavity
… and that the noise spectrum is comparable to PDH locking-explained largely due to PZT noise length fluctuations off-resonance..
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Towards Large-Scale Integrated Electronic-Photonic Systems
… available CMOS node. The implemented PDH chip utilizes an electronically reconfigurable Mach-Zehnder interferometer (MZI) as an optical frequency reference to suppress the laser's frequency noise by more than 25 dB while occupying only 2.38 mm$^2$. The integrated PDH is orders of …
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Er:YAG Lasers for Methane and Wind Sensing
… stabilised using the Pound-Drever-Hall (PDH) frequency stabilisation method to “lock” two low-power diode lasers to the Er:YAG resonator to produce reliably injectionseeded pulses. The laser designed and built in this thesis produces two free-running pulses each with energies of 0.9mJ …
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Transcriptional Regulation of the Metabolic Response to Therapy in Leukemia
… inhibit the function of Pyruvate Dehydrogenase (PDH), the enzyme responsible for the decarboxylation of pyruvate to acetyl-CoA. In line with the proposed mechanism of CPI-613, genetic screens suggested a synthetic lethal relationship between electron transport chain or TCA cycle enzymes and …
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Possible Influences of Circadian Melatonin on the Function of Neurosecretory Neurons and Serotonin-Modulated Behavior on Crayfish.
… ist dem Crustacean Pigment Dispersing Hormone (PDH), homologe das bei Krebsen in verschiedene Neuronen exprimiert wird. Mit Hilfe der Immunohistochemie und Backfill Technik konnte ich im Hirn des Marmorkrebses Strukturen identifizieren, die möglicherweise ähnlich zu Schrittmachern den optischen …
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Návrh animace digitálního spojovacího pole
… popsán návrh T spínače pro první úroveň evropské PDH E1. Mezi spínače používané v digitálních ústřednách patří prostorový spínač S a časový spínač T. Podrobněji jsou rozebrány vlastnosti T spínače a popsány způsoby jeho řízení. Podle metody řízení spínače je rozdělujeme na spínače s řízeným čtením …
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