Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"PDGFRA"”.
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Prognostischer Zusammenhang zwischen Mutationen des KIT- und PDGFRA-Gens und molekularzytogenetischen Veränderungen gastrointestinaler Stromatumoren
… Ereignis gilt dabei eine Mutation des KIT- oder PDGFRA-Gens.ZIEL: Das Ziel der vorliegenden Arbeit ist die Korrelation der Ergebnisse einer komparativen genomischen Hybridisierung (CGH) mit den Ergebnissen einer Mutationsanalyse des KIT- bzw. PDGFRA-Gens.METHODEN: 64 Tumorproben von GIST aus dem …
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Studies on the Roles of PDGFRA and EGFR in the Classification and Identification of Therapeutic Targets for Human Gliomas
… the development of targeted therapies. EGFR and PDGFRA play crucial roles in glia development and glioma pathogenesis. In this thesis we aim to establish a glial genesis-guided molecular classification scheme for gliomas based on the genes co-expressed with EGFR or PDGFRA and to clarify the …
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Unterschiedliche Aktivierung von Signalwegen zur Zellproliferation in mesenchymalen Tumoren des Gastrointestinaltrakts
… Mutationen des KIT- und seltener des PDGFRA-Gens als tumorinitiierende Ereignisse bekannt sind, weiß man bis heute wenig über die Tumorigense der leiomyogenen Tumoren des Gastrointestinaltrakts. KIT-Expression ist ein spezifisches immunhistochemisches Merkmal der GIST. Es existieren …
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Cellular plasticity in white adipose tissue: in vivo identification of bipotent adipocyte progenitors in adult white adipose tissue
… platelet-derived growth factor receptor alpha (PDGFRA), CD34 and Sca1 (PDGFRA+ cells). PDGFRA+ cells have a unique morphology in which extended processes contact multiple cells in the tissue microenvironment. Surprisingly, these cells also give rise to white adipocytes (WA) that can comprise up …
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Defining the Developmental Signals of the Cardiac Fibroblast
… population. Loss of the receptor tyrosine kinase Pdgfra also results in loss of the cardiac fibroblast population. Interestingly, Tcf21 and Pdgfra are involved in the epithelial to mesenchymal transition (EMT) of epicardial cells. The epicardium (outer surface of the heart) functions as a pool of …
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Abnormalities affecting tyrosine kinase signalling in atypical myeloproliferative disorders
… deregulated tyrosine kinase genes, notably PDGFRA, PDGFRB, FGFR1 and JAK2. However the majority of atypical MPDs still remain to be characterised and identification of patients harbouring fusions, particularly those involving the PDGF receptors is of increasing importance, as they are likely …
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Quantitative Proteinexpressionsanalysen in den klinisch-pathologischen Subtypen Gastrointestinaler Stromatumoren (GIST)
… Die quantitative Proteinexpression von KIT PDGFRA, SCF, PKC-alpha, phospho-PKC-alpha, SRC, phospho-LYN, CRKL, AKT-1, phospho-AKT-1, ERK-2, FAK, PYK-2 und cyt-PP2A wurde in Abhängigkeit von den klinisch-pathologischen Parametern Lokalisation, Morphologie, Tumorgröße, Mitosenanzahl und …
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Quantitative analysis of signaling networks in proneural glioblastoma
… increased phosphorylation of ERK1/2, P13K, and PDGFRA, relative to murine brain. Phosphorylation of CDK₁ Y₁₅, which causes G₂ /M cell cycle arrest, was measured to be the most differentially phosphorylated site, with a 14-fold increase in the tumors. We used syngeneic cell lines to investigate …
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Regulation of Lung Mesenchymal Cells By Epithelial Wnt Ligands
… Platelet derived growth factor receptor alpha (PDGFRA) – a marker of myofibroblasts that is required for alveolus formation and is reduced in bronchopulmonary dysplasia (BPD), a chronic lung disease often associated with premature birth. Mutants also showed increased smooth muscle actin (ACTA2) …
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Anti-Tumor Effects of The Notch Pathway In Gastrointestinal Stromal Tumors
… mutations of <em>KIT </em>or<em> PDGFRA</em>. Although, the introduction of tyrosine kinase inhibitors has dramatically changed the history of this disease, evidences emerge that inhibition of KIT<em> </em>or PDGFRA are<em> </em>not sufficient to cure patients. The developmental …
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The Aging-Induced Decline in Beige Adipose Tissue Development
… demonstrate that de novo beige adipogenesis from Pdgfra+ ASPCs is reduced. We see no impairment of ex vivo differentiation and observe remarkably similar ASPC populations by single cell RNA-sequencing between ages, leading to the conclusion that the defect in de novo beige adipogenesis is likely …
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Analisi genetico-molecolare dei linfomi a cellule T periferiche
… when investigating possible causes for PDGFRA deregulation, we had evidences that PDGFR over-expression is due to the absence of miR-152, which appeared to be responsible for PDGFRA silencing in normal T-cells. Furthermore, we could demonstrate that its aberrant activation is sustained …
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Interactome Analysis Identifies Novel Targets of Phosphoinositide 3-kinase (PI3K) that Mediate Astrocyte Neuroprotection
… the platelet-derived growth factor receptor A (PDGFRA), and novel interactors, such as the zinc finger CCCH-type containing 14 (ZC3H14). ZC3H14 has recently emerged as an important RNA binding protein that modifies poly-adenosine tail lengths on nascent mRNA transcripts. In downstream validation …
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Determinants of cns adult neurogenesis are sex, hormones, mouse strain, age, and brain region
… neural proliferation. At 6-8mo, the ratio of PDGFRa+ cells in the CC to BrdU+ cells in the DLC of both strains, sexes, estrous cycle and castrated mice was essentially the same, suggesting BrdU+ cells in the DLC differentiate into CC oligodendrocytes. The ratio of TUNEL+ to BrdU+ cells does …
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Comprehensive Integrated Genomic and Histopathological Analysis of Paediatric Diffuse Intrinsic Pontine Glioma
… frequent RB1 and TP53 deletions, PVT-1/MYC or PDGFRA gains/amplifications, genomic instability and alternative lengthening of telomeres. Histone mutations confer a worse overall survival (p = 0.0026). The MYCN subgroup is not associated with histone mutations and is instead characterized by …
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Platelets and Anti-Angiogenic Resistance In Ovarian Carcinoma
… implicated platelet derived growth factor alpha (PDGFRA) and transforming growth factor beta-receptor 1 (TGFBR1) signaling. Biodistribution studies suggested minimal platelet sequestration of taxanes. Blockade of platelet activation blocked <em>in vitro</em> effects. <em>In vivo</em>, …
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The molecular pathogenesis of myeloproliferative neoplasms
… (n=185) some had known<br/>abnormalities of PDGFRA or PDGFRB, but a significant minority proved negative for all molecular tests<br/>suggesting the presence of uncharacterised imatinib-sensitive mutations.<br/><br/>(iii) V617F as a marker of response to therapy. JAK2 V617F was used as a …
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Genome-scale Precision Proteomics Identifies Cancer Signaling Networks and Therapeutic Vulnerabilities
… platelet-derived growth factor receptor alpha (PDGFRA) and neurotrophic receptor tyrosine kinase 1 (NTRK1), analyzing 13,860 proteins (11,941 genes) and 30,431 phosphosites by mass spectrometry. Systems biology approaches identified numerous functional modules and master regulators, including 41 …
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Dissecting the molecular mechanisms of therapeutic resistance in cancer
… the GBM22 and MPNST3 models activated SFKs and PDGFRa signaling in resistant tumors. Across all three PDX tumor models, treatment with combination therapies, consisting of palbociclib and an inhibitor targeting the activated bypass signaling pathway, substantially prolonged survival of mice. …
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Cellular and Molecular Mechanisms Governing Intramuscular Fat Development and Growth in Cattle
… classical preadipocyte markers, such as PDGFRA, DLK1, PPARG, CD34, and ZNF423, validating their preadipocyte identity. Notably, IMF-derived clones maintained high expression of muscle-specific genes (e.g., MYOG, CKM, MYH2, MYH3), even after adipogenic differentiation. Functional …
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