Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"PDGFR-β"”.
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Downstream Signal Transduction Pathway in Human Middle Ear Cholesteatoma
… the distribution of PLC-γ1, EGFR, PI3K and PDGFR in human middle ear cholesteatoma. MATERIALS AND METHODS: Using Western blot, RT-PCR and immunohistochemical techniques, we investigated the reaction patterns of antibodies to PLC-γ1, EGFR, PDGFR-α, PDGFR-β, and PI3K as the proliferation and …
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Role of downstream signal transduction molecules of congenital middle ear cholesteatoma according to its site of origin
… and to investigate the distribution of EGFR, PDGFR, PLC-γ1, and PI3 kinase in human congenital middle ear cholesteatoma. This study may facilitate better understanding of its pathogenesis. MATERIALS AND METHODS: We reviewd 75 cases of congenital middle ear cholesteatoma to determine its …
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ASSESSMENT OF RELEVANT MOLECULAR TARGETS WITH THERAPEUTIC SIGNIFICANCE IN CANINE NEOPLASMS.
… microenvironment: FAP, EDB+FN, KIT (CD117), PDGFR-β, and OXTR. These molecules are involved in tumor progression, stromal remodeling, angiogenesis, and hormonal regulation. Results confirm that canine tumors can harbor multiple therapeutically relevant molecular targets. FAP and EDB+FN are …
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Synthesis and Molecular Modeling Studies of Bicyclic Inhibitors of Dihydrofolate Reductase, Receptor Tyrosine Kinases and Tubulin
… 3. Receptor tyrosine kinases: VEGFR2, EGFR and PDGFR-β</p><p> 4. Colchicine binding site of tublulin.</p><p> Novel homology models were generated and validated for pjDHFR, tgDHFR, tgTS, PDGFR-β and the F36C L65P pjDHFR double mutant. The tgTS homology model generated in this study and employed …
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A Tissue-Engineered Microvascular System to Evaluate Vascular Progenitor Cells for Angiogenic Therapies
… IV and laminin, and perivascular investment of PDGFR-β+/α-SMA+ cells. MPCs present in <15% of isolations displayed >98% expression for mural markers PDGFR-β, α-SMA, NG2 and supported hCB-EPC by day 14 of coculture with total tubule lengths near 12 mm/mm2. hCB-EPCs cocultured with MSCs underwent …
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Stromal Derived Growth Factor Alpha (Sdf-1Α) Induces The Differentiation of Bone Marrow Progenitor Cells (Bmcs) Into Pericytes By Regulating Platelet Derived Growth Factor B (Pdgf-B) Transcription
… types and the role of PDGF-B and its receptor, PDGFR-β, has been extensively described in the process of pericyte maturation. However, the mechanisms by which PDGF-B expression is up-regulated during vascular remodeling and the process by which BMCs differentiate into pericytes during tumor …
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Notch deficiency leads to arteriovenous malformations and altered pericyte function
… induce plated derived growth factor receptor-β (PDGFR-β) expression to regulate cell migration. These findings expand the role for Notch in angiogenesis by demonstrating that Notch signaling in pericytes is essential for vascular development and function.
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Design and Synthesis of Pyrimidine Based Heterocycles as Potential Anti-cancer Agents with Combination Chemotherapeutic Potential or Targeted One Carbon Metabolism Inhibition and Anti-opportunistic Agents
… platelet-derived growth factor receptor β (PDGFR- β) in single entities. Single agents with both antiangiogenic activities as well as cytotoxicity (via disruption of microtubule dynamics or thymidylate synthase inhibition) would afford agents that circumvent pharmacokinetic problems of …