Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 36 for “"PDGFR"”.
-
Stem-Cell Like PDGFR? Cells are Induced in Chronic Intestinal Partial Obstruction
… cells dedifferentiated into a proliferative, PDGFR?+ phenotype under hypertrophic and cultured conditions. Future directions will evaluate the potential of these cells for use in cell therapy, and will translate these findings to analagous aganglionic human disorders.
-
Mesothelial and Mural Cell Contribution to Vascular Development through PDGF Signaling
… The platelet derived growth factor beta (PDGFR beta) is essential for mural cell recruitment and expansion. Deletion of PDGFR beta leads to perinatal lethality resulting from vascular defects attributed to severe decreases in mural cells. PDGFR beta is a receptor tyrosine kinase with high …
-
Matriptase/pdgf D/beta-Pdgfr Signaling Axis In Human Prostate Cancer: The Role Of Pten In The Regulation Of Pdgf D Expression
… to stimulate its receptor, PDGF receptor beta (?-PDGFR). Importantly, recent clinical studies have shown that ?-PDGFR is upregulated in primary prostate cancer and bone metastases. However, PDGF B, formerly thought to be the sole ligand for ?-PDGFR, is not expressed in clinical prostate cancer …
-
Mechanisms of Brain Edema Formation in Mouse Models of Intracerebral Hemorrhage
… (1) VAP-1 mediated inflammatory response and (2) PDGFR-α orchestrated BBB impairment. Vascular adhesion protein-1 (VAP-1) was previously shown to promote leukocyte adhesion and transmigration. Additionally, PDGFR-α was also found to play a role in orchestrating BBB impairment. ICH injury was …
-
Downstream Signal Transduction Pathway in Human Middle Ear Cholesteatoma
… the distribution of PLC-γ1, EGFR, PI3K and PDGFR in human middle ear cholesteatoma. MATERIALS AND METHODS: Using Western blot, RT-PCR and immunohistochemical techniques, we investigated the reaction patterns of antibodies to PLC-γ1, EGFR, PDGFR-α, PDGFR-β, and PI3K as the proliferation and …
-
Role of downstream signal transduction molecules of congenital middle ear cholesteatoma according to its site of origin
… and to investigate the distribution of EGFR, PDGFR, PLC-γ1, and PI3 kinase in human congenital middle ear cholesteatoma. This study may facilitate better understanding of its pathogenesis. MATERIALS AND METHODS: We reviewd 75 cases of congenital middle ear cholesteatoma to determine its …
-
The Investigation of Targets for Therapy in Brain Tumours
… (EGFR), platelet derived growth factor receptor (PDGFR) and C-Kit, as well as the non-receptor tyrosine kinase C-Abl are often amplified, overexpressed, and/or mutated in gliomas and play an important role in glioma development. A number of tyrosine kinase inhibitors (TKIs) have been developed and …
-
Expression and Regulation of the Insulin-like Growth Factor Axis Components in Rat Liver Myofibroblasts
… und beta-Untereinheiten des PDGF-Rezeptors (PDGFR) ausschließlich in HSC und LMF exprimiert, die während der in vitro Kultivierung dieser Zellen hochreguliert wurden. Rekombinantes PDGF-BB stimulierte die DNA-Synthese von LMF in einem vergleichbaren Ausmaß wie IGF-I. Die Blockade des IGF-IR …
-
The Role of Meis1 in Hematopoietic Development
… rapidly induced expression of PDGFRα in differentiating ESCs and directly bound to evolutionary conserved E-boxes within the PDGFRα promoter. This result suggested that PDGFRα could be a direct target of <italic>Mesp1</italic>. However, we found that …
-
ASSESSMENT OF RELEVANT MOLECULAR TARGETS WITH THERAPEUTIC SIGNIFICANCE IN CANINE NEOPLASMS.
… microenvironment: FAP, EDB+FN, KIT (CD117), PDGFR-β, and OXTR. These molecules are involved in tumor progression, stromal remodeling, angiogenesis, and hormonal regulation. Results confirm that canine tumors can harbor multiple therapeutically relevant molecular targets. FAP and EDB+FN are …
-
The discovery and anticancer preclinical investigation of novel piperazinylpyrimidine derivatives designed to target the human kinome
… kinases has revealed the tendency of 4 to target PDGFR subfamily and the ability of 4 , 15 , and 16 to recognize CSNK1D. Docking as well as binding profiles comparative studies hypothesize 4 , 15 , and 16 as type-I kinase inhibitors. Further preclinical investigation of 15 against MDA-MB-468 …
-
Bim Mediates Imatinib-Induced Apoptosis of Gastrointestinal Stromal Tumors: Translational Implications
… genes encoding receptor tyrosine kinases KIT and PDGFR-α. Imatinib mesylate, a specific inhibitor of KIT and PDGFR-α signaling, delays progression of GIST, but is incapable of achieving cure. Thus, most patients who initially respond to imatinib therapy eventually experience tumor progression, and …
-
Canine Mast Cell Tumours: Characterization of Subcutaneous Tumours and Receptor Tyrosine Kinase Profiling
… and platelet-derived growth factor receptors (PDGFR) - may play a role in the progression of canine MCT; the expression and distribution of these RTK were evaluated. The results showed that canine MCT have unique expression profiles and activity of KIT, VEGFR2 and PDGFR. Two novel mast cell …
-
Therapeutic application of dominant-negative PDGF beta-receptor in liver fibrosis
… cellular effects by binding to PDGF receptors (PDGFR) and further inducing receptor dimerization and tyrosine-autophosphorylation, thus initiating various signaling pathways, amongst which MAPK and PI3K as principals. These PDGF signaling pathways may provide a potential therapeutic target to …
-
Synthesis and Molecular Modeling Studies of Bicyclic Inhibitors of Dihydrofolate Reductase, Receptor Tyrosine Kinases and Tubulin
… 3. Receptor tyrosine kinases: VEGFR2, EGFR and PDGFR-β</p><p> 4. Colchicine binding site of tublulin.</p><p> Novel homology models were generated and validated for pjDHFR, tgDHFR, tgTS, PDGFR-β and the F36C L65P pjDHFR double mutant. The tgTS homology model generated in this study and employed …
-
Analisi genetico-molecolare dei linfomi a cellule T periferiche
… the NF-kB pathway, and the tyrosin kinase PDGFR. First, we found that PTEN and p27 seem to be regulated in PTCL/NOS as in normal T-lymphocytes, as to what expression and cellular localization are concerned, and do not present structural abnormalities in the vast majority of PTCL/NOS. …
-
Gene expression-based screening of inhibitors of signal transduction
… a chemical compound library for an inhibitor of PDGFR/ERK pathway. As a result of the screen, I identified aurintricarboxylic acid, ATA, as a new inhibitor of PDGF receptor. The success of this study suggests that endogenous mRNA expression signature is an effective tool to monitor activation …
-
A Tissue-Engineered Microvascular System to Evaluate Vascular Progenitor Cells for Angiogenic Therapies
… IV and laminin, and perivascular investment of PDGFR-β+/α-SMA+ cells. MPCs present in <15% of isolations displayed >98% expression for mural markers PDGFR-β, α-SMA, NG2 and supported hCB-EPC by day 14 of coculture with total tubule lengths near 12 mm/mm2. hCB-EPCs cocultured with MSCs underwent …
-
CNS Penetration of Tyrosine Kinase Inhibitors in Mouse Models
… of platelet-derived growth factor receptor (PDGFR), crenolanib, as examples of tyrosine kinase inhibitors currently tested for treatment of malignant glioma. Given the poor microdialysis probe recovery of these lipophilic molecules, we enhanced their recovery by including an affinity-based …
Page 1 of 2