Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"PDGF-BB"”.
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Effects of transvaginal follicular aspiration on oocyte recovery, hormonal profiles before and after GnRH, and growth factor influence on embryo development
… to determine if platelet-derived growth factor (PDGF-BB) and leukemia inhibitory factor (LIF) exhibit a stimulatory effect during in vitro co-culture with Buffalo Rat liver cells (BRL). Oocytes were matured in transit, fertilized in vitro, and embryos were co-cultured with BRL cells for 7 d. The …
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Stanovení biologické aktivity rekombinantního proteinu adiponektinu pomocí buněčné kultury
… růstu buněk pomocí růstových faktorů HB-EGF, PDGF-BB a bFGF v různých koncentracích. Biologická aktivita adiponektinu poté byla stanovena jako inhibice stimulace růstu s 5 ng/ml PDGF-BB. Test biologické aktivity adiponektinu byl také proveden s lyofilizovaným adiponektinem a růstovým faktorem …
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A Method to Improve Cartilage Integration
… ± 13 μm). Each of the chemotactic agents tested (PDGF-bb, bFGF, and IGF-I) were found to induce bovine chondrocyte chemotaxis at concentrations of 25 ng/mL in modified Boyden chamber experiments. However, in bovine articular cartilage samples that were pre-treated with collagenase (0.6% for 10 …
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Expression and Regulation of the Insulin-like Growth Factor Axis Components in Rat Liver Myofibroblasts
… die Sekretion von IGFBP-3 und -2, während PDGF-BB einen inhibitorischen Einfluss zeigte. Eine Korrelation zwischen Anstieg der Proteine von IGFBP-3 und -2 im Überstand der Myofibroblasten nach Insulin- und IGF-I-Behandlung und Zunahme der spezifischen mRNA-Transkripte machte eine …
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Differential human mesenchymal stem cell responses across multi-compartment scaffolds for tendon-bone regeneration
… the elastic modulus and patterned biomolecules (PDGF-BB for proliferation; BMP-2 for osteogenesis) on CG membranes. Using this approach to explore how biomolecular and biophysical cues may work synergistically to direct MSC fate, we saw an increase in proliferation with covalently-bound PDGF-BB, …
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Interactome Analysis Identifies Novel Targets of Phosphoinositide 3-kinase (PI3K) that Mediate Astrocyte Neuroprotection
… the platelet-derived growth factor receptor A (PDGFRA), and novel interactors, such as the zinc finger CCCH-type containing 14 (ZC3H14). ZC3H14 has recently emerged as an important RNA binding protein that modifies poly-adenosine tail lengths on nascent mRNA transcripts. In downstream validation …
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THE ROLE OF P2Y RECEPTORS IN HUMAN VASCULAR SMOOTH MUSCLE
… of vascular injury, nucleotides in addition to PDGF are released from degranulating platelets, VSM cells and endothelial cells. Proliferative studies in animals show that extracellular nucleotides act as growth factors for VSM cells. PDGF is also implicated in proliferation of VSM cells in vivo …
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Single-dose growth factor treatments to enhance cell recruitment and neotissue integration in an augmented microfracture cartilage repair model
… factors (such as platelet derived growth factor-BB (PDGF-BB), transforming growth factor-P 1 (TGF-[beta]1), and heparin-binding IGF-l (HB-IGF-1)) premixed into a hydrogel scaffold could stimulate bone-marrow progenitor cell migration into the hydrogel. A novel 3D gel-to-gel migration assay, using …
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Chemotaxis of Central Nervous System-derived Tumor Cells within Controlled Microenvironments
… factor (HGF), platelet-derived growth factor (PDGF-BB), and the stromal cell-derived factors 1-alpha (SDF-1). Experiments utilized transwell assays and immunocytochemistry to identify receptor activation in MB migration, and used a microfluidic platform to examine directionality, trajectory, …
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Stimulating angiogenesis into biomaterials through the delivery of growth factors
… might have to be facilitated. Since VEGF1ss and PDGF-BB are growth factors known to stimulate and consolidate angiogenesis, this PhD thesis hypothesized, that neovascularisation of porous polyurethane (PU) can be increased by delivery of vascular endothelial growth factor (VEGF1ss) and platelet …
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Driving tissue morphogenetic cascades using tunable nanolayered surface coatings
… and mitogenic platelet derived growth factor (PDGF)-BB from 0.2-2[mu]g. Complete release of the growth factors occurred over readily adapted time scales, which extended from 8-10 days and 22-25 days for PDGF-BB and BMP-2 respectively. Each component of the system was tested for its effect on …
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Malignant Glioma: Chemosensitivity testing and Biomarkers
… gliomas. With the exception of VEGF and PDGF-BB, this is the first report of Follistatin, IL-6, IL-8 and IL-10 as biomarkers for malignant gliomas. Overall age and gender of patients did not affect the biomarker results. Brain tumours represent 2% of all cancers in the UK. Early detection …
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Integrins and SPARC : potential implications for cardiac remodeling
… die Wachstumsfaktoren TGF-Beta 1 und PDGF-BB die Expression von SPARC durch Fibroblasten. Wie sich an Hand von ELISA und Western Blot Untersuchungen feststellen ließ, war die Inhibition von Integrin Beta v nicht in der Lage, die durch TGF-Beta 1 oder PDGF induzierte Sekretion von SPARC …
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The role of heparin and heparin-binding growth factors in pre-eclampsia
… factor (HGF), platelet-derived growth factor (PDGF), heparin-binding epidermal growth factor (HB-EGF), midkine (MK), pleiotrophin (PTN), and cluster differentiation (CD105). The localisation of HBGFs and receptors VEGFR-1, /(sflt-1), PLGFR-1, VEGFR-2 and FGF2R-1 in placenta were detected. The …
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Reabilitação em curto período com PRGF de segunda geração geração associada a implantes: estudo clínico randomizado
… avaliadas, somente a IL-15 (p<0,001), o PDGF-BB (p<0,05), MIP-1b (p<0,05) e eotaxina (p<0,01) tiveram relevância estatística. Na avaliação clínica, sete participantes de pesquisa do total do estudo (10,1%) perderam o implante. Destes, quatro foram do grupo controle (5,80%) e três do grupo …
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Low-Density Lipoprotein Receptors in Signaling Modulation and Development
… the relationship between theLRP1and the PDGF receptor has been further investigated. LRP1 is known to negatively regulate the PDGF receptor. However, the exact mechanism(s) are not fully understood. In the wild-type, PDGF receptor beta binds directly to LRP1 upon ligand stimulation. LRP1 …
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Integrin Alpha Subunit Ratios, Cytoplasmic Domains, and Growth Factor Synergy Regulate Muscle Proliferation, Differentiation, and Signaling
… alters myotube morphology. TGF-$\alpha$ or PDGF-BB enhance muscle $\alpha$-actinin organization into myofibrils. bFGF and insulin promote survival of $\alpha$5 transfected myoblasts in serum-free medium. TGF-$\alpha$ and TGF-$\beta$ promote survival of untransfected myoblasts. Our …
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The influence of collagen-GAG scaffold architectural and biological cues on tenocyte and mesenchymal stem cell bioactivity for musculoskeletal tissue engineering
… sequestered) of five biomolecules (SDF-1α, PDGF-BB, IGF-1, bFGF, and GDF-5) on the recruitment, proliferation, collagen synthesis, and genomic stability of tenocytes within anisotropic CG scaffolds. Chapter 4 uses selective modification of our standard CG scaffold to probe the combined …
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The Role Of Inflammation In Pathogenesis And Treatment Of Globoid-Cell Leukodystrophy
Globoid-cell leukodystrophy: GLD, Krabbe's disease) is an autosomal recessive disease caused by a deficiency of the lysosomal enzyme galactosylceramidase: GALC). It results in altered catabolism of the myelin lipid Galactosylceramide. The disease predominantly affects the white matter of the CNS …
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Aktivierung von Caspasen in AKR-2B Mausfibroblasten
… Substanzen, die Signalwege aktivieren PDGF-BB, TPA, Forskolin und 8Br-cAMP) oder auch Substanzen, deren Verbindung zu Signalwegen noch weitgehend offen ist, schützen die Zellen vor dem Zelltod. Der protektive Effekt dieser Signalwege konzentriert sich in einem Konvergenzpunkt, der auf …
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