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Showing 1 to 20 of 128 for “"PDGF"”.
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Untersuchungen zum crosstalk zwischen Interleukin-6 und Platelet-derived growth factor (PDGF) sowie zur Signaltransduktion von PDGF-Rezeptoren
… and for the Platelet Derived Growth Factor (PDGF) as well, to play a part in the pathogeny of different types of cancer (e.g., multiple myeloma, prostate cancer). Furthermore, IL-6 and PDGF have huge relevance for inflammation processes (e.g., rheumatoid arthritis, mesangioproliferative …
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Untersuchungen zum Scherstress-responsiven Element des PDGF-Promotors
… zum Scherstress-responsiven Element des PDGF-Promotors Zellen sind im menschlichen Organismus ständig mechanischen Kräften ausgesetzt. Eine dieser Kräfte ist die spezielle Schubkraft, die durch Flüssigkeitsstrom auf Zellen ausgeübt wird und als Scherstress bezeichnet wird. Die Stimulation …
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Matriptase/pdgf D/beta-Pdgfr Signaling Axis In Human Prostate Cancer: The Role Of Pten In The Regulation Of Pdgf D Expression
<p>Platelet Derived Growth Factor (PDGF) is a family of mesenchymal growth factors that regulate cell proliferation, migration, and differentiation. Unlike the classic PDGF ligands A and B, which are secreted as active dimers, PDGF D must undergo extracellular proteolytic processing to remove its …
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Systematic Analysis of Crosstalk in the PDGF Receptor Signal Transduction Network
… in the platelet-derived growth factor (PDGF) receptor signaling network, in which phosphoinositide 3-kinase (PI3K) and Ras/extracellular signal-regulated kinase (Erk) pathways are prominently activated. We show that, while PI3K signaling is insulated from crosstalk, PI3K enhances Erk …
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Mesothelial and Mural Cell Contribution to Vascular Development through PDGF Signaling
… The platelet derived growth factor beta (PDGFR beta) is essential for mural cell recruitment and expansion. Deletion of PDGFR beta leads to perinatal lethality resulting from vascular defects attributed to severe decreases in mural cells. PDGFR beta is a receptor tyrosine kinase with high …
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Therapeutic application of dominant-negative PDGF beta-receptor in liver fibrosis
… platelet derived growth factor B-chain (PDGF-BB) which exerts cellular effects by binding to PDGF receptors (PDGFR) and further inducing receptor dimerization and tyrosine-autophosphorylation, thus initiating various signaling pathways, amongst which MAPK and PI3K as principals. These …
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The Role Of Pdgf C And Its Splice Variant In Breast Cancer
<p>The PDGF family consists of four members; while PDGF A and B are secreted as active dimers, PDGF C and D are secreted as latent dimers that undergo serine protease-mediated extracellular proteolytic activation. Gene expression analysis of breast cancer cell lines showed that PDGF C expression is …
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Mecanismos de protección frente a rotenona por PDGF-BB en un modelo astrocitario
… factores de crecimiento como el BDNF, GDNF y PDGF. En situaciones donde los astrocitos no ejecutan tales funciones, como es el caso de la producción exacerbada de especies reactivas de oxígeno (ERO) y el daño mitocondrial, sobreviene inevitablemente la muerte neuronal. Estudios recientes …
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Investigation of the role of Platelet-Derived Growth Factor (PDGF) in the development of breast carcinomas
Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, September 2002.
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Characterization of an Alternatively Spliced Platelet-Derived Growth Factor Variant During Myelin Synthesis
… spliced platelet-derived growth factor (PDGF) A-chain isoform was detected in rat dorsal root ganglion (DRG) neuron/Schwann cell cocultures and shown to regulate myelin synthesis. mRNA transcripts of the long-form PDGF-A chain variant (LF-PDGF-A) were detected by RT-PCR in cocultures. Its …
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Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats
… platelet-derived growth factor receptor (PDGF-Rα) in rat lung fibroblasts (RLF). PDGF, a potent mitogen and chemoattractant for mesenchymal cells, is an important mediator in fibrotic lung diseases. This dissertation examines the effects of pre-existing inflammation, induced by LPS, on …
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Stromal Derived Growth Factor Alpha (Sdf-1Α) Induces The Differentiation of Bone Marrow Progenitor Cells (Bmcs) Into Pericytes By Regulating Platelet Derived Growth Factor B (Pdgf-B) Transcription
… an increase in platelet-derived growth factor B (PDGF-B) mRNA levels. PDGF-B expression is elevated in several cancer types and the role of PDGF-B and its receptor, PDGFR-β, has been extensively described in the process of pericyte maturation. However, the mechanisms by which PDGF-B expression is …
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Involvement of Platelet-Derived Growth Factor, PDGF Receptor Signaling, Focal Adhesion Kinase and SRC in Pressure-Induced Vascular Smooth Muscle Hypertrophy
… which is associated with prior activation of the PDGF receptor, was not apparent at any of the time points tested. In addition, peak ERK-MAPK activation was identified at 5 minutes and was not affected by the presence of AG 1296, a PDGF receptor inhibitor. These data demonstrate that …
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Effects of transvaginal follicular aspiration on oocyte recovery, hormonal profiles before and after GnRH, and growth factor influence on embryo development
… to determine if platelet-derived growth factor (PDGF-BB) and leukemia inhibitory factor (LIF) exhibit a stimulatory effect during in vitro co-culture with Buffalo Rat liver cells (BRL). Oocytes were matured in transit, fertilized in vitro, and embryos were co-cultured with BRL cells for 7 d. The …
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Untersuchungen zum Mechanismus der PKD-vermittelten EGF Rezeptor-Transmodulation
… durch (Bagowski et al., 1999) beschriebenen PDGF-vermittelten JNK-Inhibition verifiziert. Weiterhin wurde gezeigt, dass die Liganden Endothelin und LPA, die ihre Signale über ver-schiedene G-Proteine vermitteln, in Rat1-Zellen über die Aktivierung von PKD unterschiedliche Signalwege …
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