NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 110 for “"PDGF"”.

  1. Einfluss PDGF-Rezeptor-spezifischer Antikörper auf die Chemotaxis mesenchymaler Progenitorzellen und deren Expression von PDGF-Isoformen und -Rezeptoren

    Etzel, NadineUniversität Ulm

    ulm-diss Repository record

  2. Untersuchungen zum Scherstress-responsiven Element des PDGF-Promotors

    Zeller, Michael-WulfUniversität Würzburg

    … zum Scherstress-responsiven Element des PDGF-Promotors Zellen sind im menschlichen Organismus ständig mechanischen Kräften ausgesetzt. Eine dieser Kräfte ist die spezielle Schubkraft, die durch Flüssigkeitsstrom auf Zellen ausgeübt wird und als Scherstress bezeichnet wird. Die Stimulation …

    wurz-thes Repository record

  3. Matriptase/pdgf D/beta-Pdgfr Signaling Axis In Human Prostate Cancer: The Role Of Pten In The Regulation Of Pdgf D Expression

    Conley-Lacomb, M. Katie2010

    <p>Platelet Derived Growth Factor (PDGF) is a family of mesenchymal growth factors that regulate cell proliferation, migration, and differentiation. Unlike the classic PDGF ligands A and B, which are secreted as active dimers, PDGF D must undergo extracellular proteolytic processing to remove its …

    wayne-thes Repository record

  4. Mesothelial and Mural Cell Contribution to Vascular Development through PDGF Signaling

    French, Wendy Joy2010

    … The platelet derived growth factor beta (PDGFR beta) is essential for mural cell recruitment and expansion. Deletion of PDGFR beta leads to perinatal lethality resulting from vascular defects attributed to severe decreases in mural cells. PDGFR beta is a receptor tyrosine kinase with high …

    utswmed Repository record

  5. The Role Of Pdgf C And Its Splice Variant In Breast Cancer

    Bottrell, Alyssa2014

    <p>The PDGF family consists of four members; while PDGF A and B are secreted as active dimers, PDGF C and D are secreted as latent dimers that undergo serine protease-mediated extracellular proteolytic activation. Gene expression analysis of breast cancer cell lines showed that PDGF C expression is …

    wayne-thes Repository record

  6. Investigation of the role of Platelet-Derived Growth Factor (PDGF) in the development of breast carcinomas

    Griffin, Christina MicheleMassachusetts Institute of Technology2002

    Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, September 2002.

    mit Repository record

  7. Characterization of an Alternatively Spliced Platelet-Derived Growth Factor Variant During Myelin Synthesis

    Ng, BenjaminUniversity of Illinois at Urbana-Champaign2015

    … spliced platelet-derived growth factor (PDGF) A-chain isoform was detected in rat dorsal root ganglion (DRG) neuron/Schwann cell cocultures and shown to regulate myelin synthesis. mRNA transcripts of the long-form PDGF-A chain variant (LF-PDGF-A) were detected by RT-PCR in cocultures. Its …

    uiuc Repository record

  8. Involvement of Platelet-Derived Growth Factor, PDGF Receptor Signaling, Focal Adhesion Kinase and SRC in Pressure-Induced Vascular Smooth Muscle Hypertrophy

    Rice, Darian Clark2019

    … which is associated with prior activation of the PDGF receptor, was not apparent at any of the time points tested. In addition, peak ERK-MAPK activation was identified at 5 minutes and was not affected by the presence of AG 1296, a PDGF receptor inhibitor. These data demonstrate that …

    odu Repository record

  9. Stromal Derived Growth Factor Alpha (Sdf-1Α) Induces The Differentiation of Bone Marrow Progenitor Cells (Bmcs) Into Pericytes By Regulating Platelet Derived Growth Factor B (Pdgf-B) Transcription

    Hamdan, Randala2011

    … an increase in platelet-derived growth factor B (PDGF-B) mRNA levels. PDGF-B expression is elevated in several cancer types and the role of PDGF-B and its receptor, PDGFR-β, has been extensively described in the process of pericyte maturation. However, the mechanisms by which PDGF-B expression is …

    uthsc Repository record

  10. Arterial Wall Hypertrophy and PDGF-A Expression in One-Kidney, One-Clip Hypertension and Angiotensin II Infusion Are Mediated By Elevated Arterial Pressure

    Parker, Sheri Blair2019

    … by AT1 receptor inhibition. In addition, PDGF-A mRNA was elevated in arterial walls of hypertrophied vessels. This effect was associated with elevated arterial pressure, but not with angiotensin II infusion. This PDGF-A expression was partially reduced by AT1 receptor inhibition in the …

    odu Repository record

  11. Effects of transvaginal follicular aspiration on oocyte recovery, hormonal profiles before and after GnRH, and growth factor influence on embryo development

    Carlin, Shannon K. (Shannon Kay)Virginia Polytechnic Institute and State University1995

    … to determine if platelet-derived growth factor (PDGF-BB) and leukemia inhibitory factor (LIF) exhibit a stimulatory effect during in vitro co-culture with Buffalo Rat liver cells (BRL). Oocytes were matured in transit, fertilized in vitro, and embryos were co-cultured with BRL cells for 7 d. The …

    vt Repository record

  12. Characterization of the NADPH oxidase complex in human leiomyoma and normal myometrial smooth muscle cells and its role in PDGF and EGF signaling pathways

    Mesquita, Fernando S.University of Illinois at Urbana-Champaign2010

    … that ROS are necessary components of the EGF and PDGF pathways in leiomyoma and normal myometrial SMCs. The main findings of this work were: 1) leiomyoma smooth muscle cells (LSMCs) and myometrial smooth muscle cells (MSMCs) produce ROS in response to EGF and PDGF; 2) ROS are necessary for EGF- …

    uiuc Repository record

  13. Untersuchungen zum Mechanismus der PKD-vermittelten EGF Rezeptor-Transmodulation

    Besir, ChristinaLudwig-Maximilians-Universität

    … durch (Bagowski et al., 1999) beschriebenen PDGF-vermittelten JNK-Inhibition verifiziert. Weiterhin wurde gezeigt, dass die Liganden Endothelin und LPA, die ihre Signale über ver-schiedene G-Proteine vermitteln, in Rat1-Zellen über die Aktivierung von PKD unterschiedliche Signalwege …

    lmu-germany Repository record

  14. Expression and Regulation of the Insulin-like Growth Factor Axis Components in Rat Liver Myofibroblasts

    Novosyadlyy, Ruslan2012

    … die Sekretion von IGFBP-3 und -2, während PDGF-BB einen inhibitorischen Einfluss zeigte. Eine Korrelation zwischen Anstieg der Proteine von IGFBP-3 und -2 im Überstand der Myofibroblasten nach Insulin- und IGF-I-Behandlung und Zunahme der spezifischen mRNA-Transkripte machte eine …

    goettingen Repository record

  15. The Regulation and Mechanism of Myelin Synthesis Involving Endogenous Steroid Hormones

    Chan, Jonah R.University of Illinois at Urbana-Champaign2015

    … study, the platelet-derived growth factor (PDGF) A-chain was detected as two distinct splice variants in Schwann cell/neuronal co-cultures. Both PDGF A-chain isoforms were characterized and examined throughout the myelination process. The mRNA for the long form PDGF A-chain was found to be …

    uiuc Repository record

  16. Steroid Hormone and Growth Factor Regulation of Peripheral Myelination

    Thu, Thant SiUniversity of Illinois at Urbana-Champaign2015

    … signaling by platelet-derived growth factor (PDGF)-A in peripheral myelination was investigated. Lower levels of P0 were found in the developing sciatic nerve of PDGF-A null transgenic mice, especially when active myelin synthesis occurs. Morphological deformities of the myelin sheath were …

    uiuc Repository record

  17. Regulation of Cardiac Fibroblast and Coronary Vascular Smooth Muscle Development by Platelet Derived Growth Factor Receptors

    Smith, Christopher Lacey2015

    … mice with epicardial specific deletions of the PDGF receptors, I discovered that these receptors control EPDC fate and epicardial EMT. I demonstrated that each receptor was required for development of a unique epicardial derivative, PDGFRα for cardiac fibroblasts and PDGFRβ for cVSMC. I also …

    utswmed Repository record

  18. Low-Density Lipoprotein Receptors in Signaling Modulation and Development

    Dietrich, Martin Frederik2010

    … the relationship between theLRP1and the PDGF receptor has been further investigated. LRP1 is known to negatively regulate the PDGF receptor. However, the exact mechanism(s) are not fully understood. In the wild-type, PDGF receptor beta binds directly to LRP1 upon ligand stimulation. LRP1 …

    utswmed Repository record

  19. Discovering angiogenic cell signaling landscapes: Quantitative mapping through experiment and computation

    Mamer, Spencer BruceUniversity of Illinois at Urbana-Champaign2019

    … involves other signaling axes, such as the PDGFs. In cancer, for example, anti- angiogenic therapeutics primarily target the VEGF signaling family, but their success is limited by the development of drug resistance. These challenges in VEGF targeting, and recent discoveries of VEGF-A:PDGFR …

    uiuc Repository record

  20. The role of mitochondria in regulating smooth muscle cell proliferation and migration in pulmonary hypertension

    Burzangi, AbdulHadi Salem H.University of Strathclyde2020

    … in response to platelet-derived growth factor (PDGF) and hypoxia. Aims were first to determine the appropriate model of hypoxia-induced cell proliferation among different degrees of hypoxia. The second aim was to investigate the role of the mitochondria in regulating cell proliferation and …

    strathclyde Repository record

Page 1 of 6