Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"PDE7B"”.
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Transcriptional Analysis of Reciprocal Tumor-Microenvironment Interactions in Glioblastoma
… of the cAMP specific phosphodiesterase PDE7B in GBM cells in response to ECs. We further found that elevated PDE7B expression occurs in most GBM cases and has a negative effect on survival. PDE7B overexpression resulted in the expansion of a stem-like cell subpopulation, increased tumor …
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The Human Pancreatic Islet Methylome and Its Role in Type 2 Diabetes
… mRNA expression in T2D islets, including CDKN1A, PDE7B, SEPT9 and EXOC3L2. Our functional experiments provided further evidence that altering the expression of these genes, by modeling the situation in T2D, results in impaired insulin and glucagon secretion in cell line models. Furthermore, we …
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Studies in beta cells and adipocytes in the context of obesity and T2D - focusing on PDE3B, OPN and SCFAs
… Furthermore, PDE1A, PDE3, PDE4C, PDE5A, PDE7A, PDE7B, PDE8A, PDE10A and PDE11A are detected in human pancreatic islets. Islets from RIP-PDE3B mice, exhibiting β-cell specific overexpression of the cAMP-degrading enzyme phosphodiesterase 3B (PDE3B) and dysregulated insulin secretion, show induced …