Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"PDE5"”.
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Liposomal delivery of PDE5 inhibitors and UT-15C to human erythrocytes
… or its analogs and phosphodiesterase 5 (PDE5) inhibitors. These medications can be used alone or in combination and may have serious unwanted side effects that are additive when used in combination.</p><p>Here an alternative drug delivery technique using drug-loaded liposomes is …
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PATHOGENIC ROLE OF PHOSPHODIESTERASE TYPE 5 UPREGULATION IN CARDIAC ISCHEMIA/REPERFUSION INJURY
Phosphodiesterase Type 5 (PDE5) inhibitors are cardioprotective against ischemia/reperfusion (I/R) injury. However, it remains uncertain if I/R affects PDE5. We hypothesized that generation of reactive oxygen species (ROS) during I/R leads to upregulation of PDE5, which contributes to pathological …
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Ανάδειξη νεφροπροστατευτικής δράσης φαρμακευτικών παραγόντων σε πειραματικό μοντέλο ισχαιμίας επαναιμάτωσης στον επιμύ
… διαδεδομένου αναστολέα της φωσφοδιεστεράσης 5 (PDE5) σε ένα πειραματικό μοντέλο ισχαιμίας-επαναιμάτωσης στον αρουραίο. Υλικά και μέθοδος: Στο σύνολο 71 αρουραίοι ράτσας Wistar διαχωρίστηκαν σε 7 ομάδες συμπεριλαμβανομένης μιας ομάδας μάρτυρα, μιας ομάδας ελέγχου, 4 ομάδων χορήγησης βαρδεναφίλης …
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Sexual risk among men who have sex with men with online sex partners in New York City: . . .
… (also known as erectile dysfunction drugs or PDE5 inhibitors), and group sex participation and mode of sex partner recruitment are examined. Univariate, bivariate, and multivariate analysis were used to examine the research questions and hypothesis.
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Modelling protein backbone loops using the Monte Carlo method
… lysozyme L99A mutant, Bcr-Abl kinases and PDE5 phosphodiesterase<br/>and led to increased sampling of the backbone and more precise free energy<br/>results.
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Development of Protein Degraders Inspired by Chemical Modifications
… of the Dha handle into phosphodiesterase type-5 (PDE5) and androgen receptor (AR) binders also promoted target degradation, highlighting the potential of the Dha handle as a versatile scaffold for E3 ligase recruitment toward diverse disease-relevant proteins.
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Role of Nitric Oxide-Signalling in Hypoxia-Induced Immune Escape in Cancer
… to determine whether treatment with the PDE5/6 inhibitor zaprinast could also attenuate hypoxia-induced MICA shedding and decrease in vivo growth of DU-145 tumours. Results demonstrated that treatment with zaprinast (10 mg/kg) significantly attenuates MICA shedding in DU-145 cancer cells …
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Regulation of mammalian photoreceptor phosphodiesterase (PDE) by its noncatalytic GAF domains and its two small subunits, gamma and delta
… cGMP binding at the GAF domains. Similar to PDE5, phosphorylation of photoreceptor Palphabeta regulates cGMP binding at the GAF domains. These results suggest a potential role of Palphabeta phosphorylation in regulating PDE by regulating cGMP levels in photoreceptor cells.</p>
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Biphasic neurogenic vasodilatation in the bovine intraocular long posterior ciliary artery
… was clearly mediated by NO, inhibitors of PDE5, PKG and the soluble guanylate cyclase/cGMP/NO pathway had no effect on the second component of vasodilatation. 8.Furthermore, various K+ channel blockers, or inhibitors of the PKA/cAMP pathway did not inhibit the second component of neurogenic …
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Potential Natural Product Phosphodiesterase Inhibitors
… were screened by computer modeling of PDE5A1. Second, compounds were isolated from a plant traditionally used as an aphrodisiac. Third, a new synthesis of psychoactive PDE4 inhibitor was attempted. An in silico screen was performed using chemical structures of isolated compounds thought …