Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"PDE3B"”.
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Hormonal regulation of phosphodiesterase 3B in adipocytes
… with knowledge on the acute activation of PDE3B in response to insulin and catecholamines in adipocytes. The activation of PDE3B was investigated from three different perspectives namely; phosphorylation of PDE3B, localization of PDE3B and PDE3B interactions with other proteins. As models …
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Studies in beta cells and adipocytes in the context of obesity and T2D - focusing on PDE3B, OPN and SCFAs
… of cyclic nucleotide phosphodiesterase 3B (PDE3B) in pancreatic β-cells. We show that PDE3B is activated in response to glucose, insulin and forskolin, which is coupled to a decrease, no apparent change or an increase in total phosphorylation of the enzyme in rat pancreatic β-cells. …
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THE ROLE OF PHOSPHODIESTERASE 3B IN CAMP-MEDIATED REGULATION OF INSULIN SECRETION
… of ?-cell cAMP-degrading phosphodiesterase 3B (PDE3B) in the regulation of insulin secretion and whole body energy homeostasis. The specific aims were (i) to study the physiological importance of well-regulated ?-cell-cAMP levels for insulin release and whole body energy homeostasis during a …
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The Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… indicate that G-CSF activated the JAK/PI3K/Akt/PDE3B pathway, which in turn inhibited corticosterone synthesis. The inhibitors of JAK/PI3K/PDE3B respectively Tyrphostin AG490, LY-294002, and 3-isobutyl-lmethylxanthine reversed the inhibitory effect of G-CSF on corticosterone synthesis. We report …
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Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… indicate that G-CSF activated the JAK/PI3K/Akt/PDE3B pathway, which in turn inhibited corticosterone synthesis. The inhibitors of JAK/PI3K/PDE3B respectively Tyrphostin AG490, LY-294002, and 3-isobutyl-1methylxanthine reversed the inhibitory effect of G-CSF on corticosterone synthesis. We report …
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Functional validation of human rare missense variants associated with body fat distribution and cardiometabolic risk
… p.N150H), CALCRL (p.L87P), PLIN1 (p.L90P) and PDE3B (p.R783X) which were associated with a favourable body fat distribution and with protection from cardiometabolic disease, while a variant in gene PNPLA2 (p.N252K) was associated with an adverse phenotype (1). To understand the roles of these …
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Causal Gene Prioritization Across Diverse Diseases Through Multi-Omic Data Integration
… identified five genes (*PLIN1*, *INSR*, *ACVR1C PDE3B*, *PLIN4*) associated with body fat distribution, assessed by waist-to-hip ratio adjusted for body mass index (WHRadjBMI). LoF variants of *PLIN4*, *INSR* and *PDE3B* showed significantly larger standardized effect sizes for females compared …
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Transcriptional adaptation of adipose tissue in dairy cows in response to energy overfeeding
… expression in subcutaneous AT, but decreased PDE3B expression during periparturient period. Part of AT from biopsy of -10 and 7 d was used for tissue explant and challenged with hyperphysiological bovine insulin in vitro. Over-consumption of dietary energy increased and decreased …
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Transition cows: hepatic endocannabinoid system gene expression in response to prepartal plane of nutrition and the effects of genetic merit on genes of lipid metabolism in adipose tissue
… genes controlling lipolysis (INSR, AKT1, PDE3A, PDE3B, PRKAA1, PRKAA2, FOXO1, SIRT1), and other proteins (GHR, CAV1, ADIPOQ, TNF1) was also measured. Dry matter intake, blood glucose and NEFA were not significantly different in both groups. Milk production had the tendency to produce more milk in …