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Showing 1 to 3 of 3 for “"PDE3A"”.

  1. Physical and Functional Coupling of CFTR and PDE3A

    … we demonstrated that phosphodiesterase type 3A (PDE3A) is physically and functionally coupled to cystic fibrosis transmembrane conductance regulator (CFTR). PDE3A inhibition increases cyclic adenosine 3′, 5′-monophosphate (cAMP) levels in a compartmentalized manner at the plasma membrane, which …

    tenn-hsc Repository record for Physical and Functional Coupling of CFTR and PDE3A (opens in a new tab)

  2. Identifying Observational and Causal Factors for Cardiovascular Diseases through Large-scale Cohorts

    … an inhibitor of Phosphodiesterase 3A (PDE3A), as a repurposing opportunity for the primary prevention of CHD and a safer alternative to existing antiplatelets. Lastly, I developed race- and sex- risk prediction models for two subtypes of heart failure, defined by preserved (HFpEF) or …

    cambridge Repository record for Identifying Observational and Causal Factors for Cardiovascular Diseases through Large-scale Cohorts (opens in a new tab)

  3. Transition cows: hepatic endocannabinoid system gene expression in response to prepartal plane of nutrition and the effects of genetic merit on genes of lipid metabolism in adipose tissue

    … ABHD5), genes controlling lipolysis (INSR, AKT1, PDE3A, PDE3B, PRKAA1, PRKAA2, FOXO1, SIRT1), and other proteins (GHR, CAV1, ADIPOQ, TNF1) was also measured. Dry matter intake, blood glucose and NEFA were not significantly different in both groups. Milk production had the tendency to produce more …

    uiuc Repository record for Transition cows: hepatic endocannabinoid system gene expression in response to prepartal plane of nutrition and the effects of genetic merit on genes of lipid metabolism in adipose tissue (opens in a new tab)