Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"PDE1C"”.
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The Role of Ca²⁺/CaM-Stimulated Phosphodiesterase 1C in Vascular Smooth Muscle cells of the Synthetic/Activated Phenotype
… have established that phosphodiesterase 1C (PDE1C), a PDE not produced in contractile/quiescent VSMCs is upregulated, and the functionally dominant PDE in the presence of calcium in these cells. This study looked to establish a role for PDE1C in synthetic/activated VSMCs as it relates to the …
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Investigating the Role of Phosphodiesterase 1C in Vascular Smooth Muscle Cell Migration and Invasion
… role of cyclic nucleotide phosphodiesterase 1C (PDE1C) in HASMC migration, proliferation, and extracellular matrix adhesion. Here, we directly tested the hypothesis that cAMP signaling, and specifically PDE1C, influences the ability of activated/synthetic HASMCs to invade matrix in 3-dimensions …
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Crosstalk Signaling Between cAMP and Calcium on the Leading Edge of Migrating Human Arterial Vascular Smooth Muscle Cells
… Since the cyclic nucleotide phosphodiesterase, PDE1C, a dual cAMP/cGMP hydrolyzing PDE, is exclusively expressed by synthetic VSMCs and regulates their synthetic, migratory and proliferative actions, it may represent a valid synthetic VSMC specific therapeutic target. Store operated calcium …
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The Identification and Validation of Novel Aptamers to Glioma
… important for gliomagenesis; EGFRvIII and PDE1C. Ten DNA aptamers were isolated towards a peptide within the mutated region for EGFRvIII and four aptamers were targeted towards the PDE1C protein. Whilst validation studies via Western blot showed no aptamer-protein interaction when using the …