Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"PD1"”.
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Analysis of soluble high-affinity PD1 variants
… a checkpoint inhibitor therapeutic to inhibit PD1/PD-L1 signalling. Mesenchymal stem cells (MSCs) offer an alternative drug delivery method for delivering this treatment to the pancreas due to their ability to infiltrate tumours and deliver a therapeutic pay load. In this study soluble PD1 …
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DELINEATING GUT-MEDIATED RESPONSE AMONG MELANOMA PATIENTS UNDERGOING ANTI-PD1 IMMUNOTHERAPY
… followed at baseline and over the course of anti-PD1 immunotherapy, collecting fecal and blood samples, from which we surveyed the gut microbiota, metagenome, and systemic immune profile. For validation, fecal samples from tumor-free subjects were used as reference; gut variability measures were …
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The novel roles of BCL6 and BATF3 in regulating human CD8⁺ T cell dysfunction
… CD8⁺ T cells identified a distinct BCL6^high PD1⁻ progenitor population that gives rise to two distinct subsets via divergent differentiation trajectories: one branch generates effector-like BCL6^high PD1⁺ cells, whereas the other produces BCL6^high PD1⁺ cells that retain an exhaustion gene …
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Generation and in vivo validation of multi-functional antibody-fusion proteins for cancer therapy
… checkpoint inhibitor combining anti-PD1 with the L19 antibody. The tumor-targeted immune checkpoint inhibitor has been characterized in vitro and preliminary results in vivo indicated corrected localization of the fusion protein to the neoplastic lesion, sparing healthy organs. …
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An exploration of advanced nursing in a hospital context: people, processes, frameworks.
… with two inter-linked PD projects. Project 1 [PD1]: 'Specialised Nurse Review' [SNR] based in an acute hospital focused on production and implementation of an advanced nursing framework. Project 2 [PD2] involved leading on education curriculum development for advanced nursing, at a local …
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Clinical and Therapeutic Significance of Obesity In Melanoma
… mice treated with a) D+T and b) anti-PD1.</p> <p>Obesity was associated with significantly improved PFS and OS in MM patients treated with both targeted therapy and immunotherapy but not chemotherapy. Improved outcomes were not attributable to differences in clinical prognostic factors …
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Influence of food intervention on enteric nervous system and enteroendocrine cells development in a small for gestational age piglet model
… enteroendocrine cells (EECs), respectively. At PD1, the ENS of AGA animals was almost fully developed compared with PD14 and PD28. For SGA piglets, a delayed development of nerve endings was observed on PD1 associated with a less developed synaptic system in the enteric nervous ganglia, …
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Clonal Phenotype Mapping Reveals Genomic Alterations Underlying Tumor Immunosuppression during Immunotherapy
… we tracked clonal dynamics in response to anti-PD1 therapy and found that while treatment had limited impact on overall tumor volume, it induced profound shifts in clonal composition. Spatial lineage analysis of treatment-naïve tumors revealed that clones with distinct immunotherapy …
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The study of weak ferromagnetism by andreev reflection spin spectroscopy and development of bimorph electro-thermal actuators
… and sputtering. Another system studied was Pd1-xNix which is an example of the strong ferromagnetic susceptibility enhancement of nearly ferromagnetic Pd by Ni impurities. The transport spin polarizations of Pd1-xNix with different Ni concentrations were measured and their correlation with …
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Development and testing of inorganic membranes for hydrogen separation and purification in a catalytic membrane reactor.
… at different coatings. A thin palladium (Pd1) membrane with a thickness of 2 μm was prepared over porous ceramic alumina support using the electroless plating method and a maximum hydrogen flux of 80.4 cm3 cm-2 min-1 was observed at 873 K and 0.4 bar after annealing the membrane. The …
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Harnessing Cancer Omics to Inform Precision Oncology
… of melanoma brain metastasis (MBM) during anti-PD1 therapy using single cell RNA sequencing (scRNA-seq) of patients’ cerebrospinal fluid (CSF) samples. We profiled functional proteomics from kidney tumor samples using reverse phase protein array (RPPA) and formulated an MTOR score that improves …
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Characterizing The Role of Uchl5 In Metastatic Melanoma
… cells and were also treated with anti-mouse PD1 led to increased tumor burden. We find that UCHL5 plays a role in the progression of metastatic melanoma and contributes to an increased tumor burden. These findings can provide insight into how we approach treatment for metastatic melanoma, …
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Impact of endosomal recycling inhibitors on drug resistant and immune tolerant breast cancers
… receptors on the surface of T cells. PDL1-PD1 binding leads to T cell inactivation. A number of ERIs were used to determine their impact on the levels of PDL1.
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ROLE OF IL-10 PRODUCING EOMES+ TR1-LIKE CELLS IN MELANOMA
… patient survival and predict responses to anti-PD1 immunotherapy in melanoma patients. Moreover, in vitro studies have demonstrated that human EOMES+ Tr1-like cells exhibit a reduced capacity to suppress antigen- experienced CD8+ T cells in the presence of anti-PD1 antibodies. In this study, we …
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Understanding and Targeting The Immunosuppressive Tumor Microenvironment
… checkpoint inhibitors (ICIs), such as anti-PD1/PD-L1 and anti-CTLA-4, have shown impressive antitumor efficacy by improving the activity of T cells. While these inhibitors work in many patients with various cancer types, they have minimal or no effect in many more patients. Mounting evidence …
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Binäre und Ternäre Verbindungen der Platinmetalle Palladium und Rhodium mit Tellur und Halogenen. Präparationen und strukturelle Charakterisierung.
… Durch Transport bildete sich einkristallines Pd1-xTe im unverzerrten <br>NiAs-Typ aus, mit für PdII-low-spin-d8 ungewöhnlicher oktaedrischer Koordination, <br> dTe-Te=369 pm, c/a = 1.38. Aus Rh, Te und Cl2 mit AlCl3 bei 900°C wurden durch Transportreaktion <br>Einkristalle von RhTeCl und …
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T Helper Cell Dysfunction in ANCA Associated Vasculitis
… T helper (PTH) cells, characterised by the PD1+CXCR5- phenotype, was described in the context of auto-immune diseases, driving organ inflammation. These pathogenic cells were shown to infiltrate sites of inflammation and have the necessary machinery to provide B cell help in the peripheral …
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Immunological and biosynthetic studies of the human pyruvate dehydrogenase complex
… the serum of more than 95% of patients with PBC. PD1 and PD2 are monoclonal antibodies (mAbs) secreted by individual patient-derived hybridomas (IgG/λ) that interact with a common lipoylation-dependent epitope found on both E2 and E3BP lipoyl domains although the precise antigenic determinant has …
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Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance
… exhausted states, and the efficacy of anti-PD1 is improved. Thus, tumor anti-viral signaling sustains epigenetic changes which enable cancer cells to amplify IFN-I response and drive immunotherapy resistance.
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Surface structures of Al-Pd-Mn and Al-Cu-Fe icosahedral quasicrystals
… are periodic and correspond to cubic [beta]-Al(Pd1-xMnx) or [beta]-Al(Cu1-xFex) with CsCl structure. The orientations of the cubic phases are (111) on threefold surface, (110) on twofold and fivefold surfaces;The high temperature LEED patterns have very sharp LEED spots. The symmetries and spot …
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