Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"PD-L2"”.
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Investigating The Distinct Role of Pd-L2 In Modulating Human T Cells Responses
<p><strong>INVESTIGATING THE DISTINCT ROLE OF PD-L2 IN MODULATING HUMAN T CELL RESPONSES</strong></p> <p>Anupallavi Srinivasamani, M.S.</p> <p>Advisory Professor: Michael A. Curran, Ph.D.</p> <p>Therapeutic blockade of the Programmed cell death-1 (PD-1) receptor and its ligand Programmed death …
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Immune Checkpoint Molecule Expression in Canine Lymphoma and Canine Reactive Lymphoid Hyperplasia
… using checkpoint molecule blockade of PD-1 and PD-L1 shows promise for various types of human cancer, including relapsed/refractory lymphoma; however, little is known regarding the role of these checkpoint molecules in canine lymphoma. Objectives: To determine the patterns of expression …
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Roles For Braf Kinase Activating Mutations In Melanoma: Microenvironmental Immunosuppression
… factors, including COX-2 and the PD-1 ligands PD-L1 and PD-L2. Specific BRAF(V600E) inhibitors largely abrogated the ability of melanoma cells to confer T cell-suppressive properties on TAFs. These results support a model in which BRAF(V600E) promotes immune suppression in the …
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Human Inborn Errors of Immunity: Tuberculosis, Autoimmunity, and Beyond
… TB in children and young adults: inherited ITK, PD-1, and LY9 deficiencies.These rare genetic defects partially impair IFN-γ production by diverse T cell subsets through distinct mechanisms such as development, exhaustion, and epigenetic imprinting.Thus, the first part of my graduate research …
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Regulation of Anti-Viral Cd8+ T Cell Responses by the Pd-1 Pathway
PD-1 and its ligands, PD-L1 and PD-L2, constitute a critical immunoregulatory pathway for modulating CD8+ T cell responses. This pathway has become an important therapeutic target in cancer and chronic viral infections, where blockade of PD-1/PD-L1 reverses CD8+ T cell exhaustion and improves …
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Molecular basis of immunotolerance in canine neoplasia
… immunosuppressed. Checkpoint molecules from the PD-axis are overexpressed in numerous human malignant neoplasia and have recently gained attention with a few reports in canine tumors. Immunotherapies against these checkpoint molecules have shown great efficacy in humans, but in order to determine …
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CD4+ T cells in the pathogenesis of visceral leishmaniasis
… receptors and ligands, respectively. Blocking PD-L2 led to a significant decrease in parasite burden revealing a pathogenic role for the PD-1 pathway in chronic visceral leishmaniasis. Inhibitory molecules are possible targets for immunotherapeutics or combinatory treatment regimens for chronic …
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T-Bet Expressing B Cells With Distinct Residency And Functional Characteristics Give Rise To Plasma Cells
… infection, acquire the memory markers CD73, PD-L2 and CD80, and persist indefinitely with limited interconversion between T-bet+ and T-bet- B cell pools. Moreover, T-bet+ B cells are required for HA stalk specific antibodies and sustained protective HAI titers. T-bet+ HA-specific B cells can …
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Disruption of Immunoregulatory Functions of Intestinal Mesenchymal Stromal Cells and their Progenitors in Inflammatory Bowel Disease
… that express Programmed Death-Ligands 1 & 2 (PD-L1/2) to promote immune tolerance. However, PD-L1 signaling is altered in IBD for as yet unknown reasons. Gremlin 1+ (Grem1) Mesenchymal Stromal progenitor Cells (MSCs) are progenitors of CMFs under homeostasis, but their fate during IBD …
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The role of the PD-1 pathway in the tumor microenvironment
… antibodies blocking the programmed death (PD)-1 pathway have been approved for the treatment of metastatic melanoma, non-small cell lung cancer, and renal cell carcinoma, amongst others. However, only a limited number of patients respond to these therapies. The field is now trying to …
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Autologous Proliferative and Immunobiological Modelling of Patient-Derived Clear Cell Renal Cell Carcinoma and Kidney Organoids
… However, patient-derived ccRCC organoids (PDO-ccRCC) proliferate poorly ex vivo and the consequences of expansion on healthy kidney organoid controls (PDO-KO) and autologous T cell expansion are poorly understood. In this dissertation I present systems for autologous preclinical modelling …
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The interactions of tolerogenic dendritic cells, induced regulatory T cells and antigen-specific IgG1-secreting plasma cells in asthma
… expressed lower levels of CD40, CD80, MHC II, PD-L1 and PD-L2 relative to immunostimulatory LPS-differentiated DCs (DCLPS). Co-culturing DC10 or DC10-induced regulatory T cells (iTreg) with CD4+ Th2 effector T cells from asthmatic mice led to a marked suppression of DCLPS-induced T effector …
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Immune checkpoints in oral carcinogenesis
… immune checkpoint inhibitors (ICIs), namely anti-PD-1. These ICIs provide improved survival rates, and the expression of the immune checkpoints (ICs) are being investigated as potential prognostic factors. This dissertation aimed to investigate the role of ICs in the development of oral …