Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"PD-1 deficiency"”.
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Cellular and Molecular Mechanisms of Immunoregulation In Vivo
… and adaptive responses. Programed death-1 (PD-1) is an inhibitory co-stimulatory molecule originally described to promote exhaustion or inhibit the function of effector T cells. PD-1 deficiency is associated with tissue specific autoimmune disease while overexpression leads to immunological …
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Regulation of Anti-Viral Cd8+ T Cell Responses by the Pd-1 Pathway
PD-1 and its ligands, PD-L1 and PD-L2, constitute a critical immunoregulatory pathway for modulating CD8+ T cell responses. This pathway has become an important therapeutic target in cancer and chronic viral infections, where blockade of PD-1/PD-L1 reverses CD8+ T cell exhaustion and improves …
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Human Inborn Errors of Immunity: Tuberculosis, Autoimmunity, and Beyond
… TB in children and young adults: inherited ITK, PD-1, and LY9 deficiencies.These rare genetic defects partially impair IFN-γ production by diverse T cell subsets through distinct mechanisms such as development, exhaustion, and epigenetic imprinting.Thus, the first part of my graduate research …