Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"PCHi-C"”.
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Integrative statistical methods for the genomic analysis of immune-mediated disease
… 3, I hypothesised that promoter-capture Hi-C (PCHi-C) data might have utility in physically linking disease-associated regulatory variants to their target genes, in a tissue-specific manner. To examine the genome-wide enrichment of GWAS summary statistics within PCHi-C chromatin contact maps I …
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The interplay of global chromosomal organisation, promoter-enhancer interactions and transcription
… of high-resolution Promoter Capture Hi-C (PCHi-C) data to investigate the localisation of promoter interactions with respect to TAD boundaries in human primary blood cells and cell-cycle synchronised HeLa cells. I show that the majority of promoter interactions originate at, and are …
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STUDIES OF B CELL DEVELOPMENT AND V(D)J RECOMBINATION
The process of generating the vast diversity of immunoglobulin receptors and secreted antibodies begins with the recombination of the joining (JH), diversity (DH) and variable (VH) genes in the immunoglobulin heavy chain locus. The ability to produce antibodies is restricted to the B cell lineage …