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Showing 1 to 4 of 4 for “"PCAWG"”.
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Mapping the Genomic Context of Mutagenesis
… and 3,824 metastatic cancer genomes of the PCAWG consortium and the HMF cohort shows that practically all signatures operate dynamically in response to various genomic and epigenomic states. The analysis pins differential spectra of UV mutagenesis found in active and inactive chromatin to …
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Patterns of somatic genome rearrangement in human cancer
… discovery and matching. Finally, I return to the PCAWG SV dataset, and extract SV signatures delineated by structural class, size, and replication timing. In Chapter 5, I move on to the complex SV clusters (largely set aside throughout Chapters 2—4) , and develop an improved breakpoint clustering …
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Compositional models for mutational signature analysis
… mutations across 23 cancer types of the PCAWG cohort. There is ubiquitous change, which can be detected already at nucleotide level. There is higher dispersion – higher variability between samples – of signatures in the subclonal group, indicating, possibly, the presence of di↵erent …
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Signatures of chromosomal instability in human cancers
Chromosomal instability (CIN), defined as the process of losing or gaining whole or parts of chromosomes, is one of the earliest molecular characteristics to be described in cancer. Since its detection by light microscopy in the late 19th century, technological advances have facilitated the …