Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"PCAF"”.
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The search for small molecule inhibitors of histone acetylation
… molar HAT inhibitory activity towards the HATs PCAF and p300 and is<br/>able to suppress cancer cell growth. In contrast, the azumamides are a series of cyclic tetrapeptides<br/>that were discovered in Mycale izuensis, a Japanese marine invertebrate. Azumamides A-E exhibit<br/>nano molar HDAC …
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Understanding C/EBPbeta LAP/LIP Transcriptional and Adipogenic Potential Through Regulation by HDAC1 and GCN5
… For instance, the acetyltransferases GCN5/PCAF and the deacetylase complex mSin3A/HDAC1 regulate C/EBPβ activity on the C/EBPa promoter. GCN5/PCAF-mediated acetylation of C/EBPβ was shown to positively affect its transcriptional activity in a steroid-dependent mechanism via the …
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H2O2-mediated oxidation and nitration enhances DNA binding capacity / DNA repair via up-regulated epidermal wild-type p53 in vitiligo.
… lys 373, 382 residues correlates with increased PCAF expression. We show that up regulated p53 is associated with over expressed p21 (cyclin dependent kinase inhibitor 1) and induced PCNA 4 expression. Hence, we can conclude that p53 in patients with vitiligo is up regulated, activated and …