Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 93 for “"PC3"”.
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Induction of Cellular Induction Senescence by BTG2_(TIS21/PC3) Gene in Huh7 Hepatocellular carcinoma Cells
TIS21^(BTG2/PC3) regulates G1-S and G2-M progressions of cell division cycle through the inhibition of G1 phase cyclin biosynthesis, and the delayed degradations of cycin B1 and cyclin A, respectively. Therefore, we earlier suggested that TIS21 might play a role as a pan-cell cycle regulator and an …
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Role of BTG2/TIS21/PC3 in differentiation of myeloid leukemia cells and its regulation under stress conditions
… human BTG2 (B-cell translocation gene 2) and rat PC3, is a tumor suppressor that belongs to antiproliferative gene family, and is implicated in a variety of biological processes. Deregulation of c-Myc transcription factor is common in leukemia and lymphomas; the tumors are highly proliferative and …
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RESISTANCE TO VESICULAR STOMATITIS VIRUS IS INTRINSIC TO PC3 PROSTATE CANCER CELLS AND CAUSES INHIBITION OF EARLY STEPS OF THE VIRUS REPLICATION CYCLE
… steps of the virus replication cycle in PC3 prostate cancer cells (VSV-resistant cells) to LNCaP prostate cancer cells (VSV-sensitive cells). My experiments revealed that several early steps of the viral replication cycle are delayed in PC3 cells, including virus penetration and primary …
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Cellular response to 11[beta]-dichloro, a novel aniline mustard-estradienone, in various prostate cancer cell lines
… were used, namely, LNCaP (AR-positive, T887A), PC3 (AR-negative, p53 inactive), DU145 (AR-negative, p53 null), and the isogenic pair PC3-AR (AR-positive) and PC3-neo (AR-negative), which only differ in the AR status. Growth inhibition with LNCaP, PC3, and DU 145 cells showed that LNCaP cells are …
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Role Of Thromboxane Receptor-Alpha In Prostate Cancer Progression
… plasmid encoding TPα into another PCa cell line, PC3 (PC3-TPα), led to a similar phenotype in response to IBOP, thereby confirming a link between TPα and over expression of AREG and EGFR. </p> <p> Increase in AREG expression mediated by TPα seems to involve EGFR and AMP activated protein kinase …
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Relevance of Fgfr1 and Its Isoforms In Prostate Cancer Bone Metastases
… and pathways in human PCa. Direct injection of PC3 PCa cells overexpressing FGFR1 isoforms into the femur of mice resulted in enhanced tumor growth and reduction in bone volume when compared with PC3 expressing empty vector. However, only PC3 overexpressing FGFR1 b was associated with increased …
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Analysis of cellular responses to microwave irradiation in E. coli and change of oxygen level and culture medium in human cancer cell lines using RNA-seq based transcriptomic profiling
… lines (MCF7) and prostate cancer cell lines (PC3) as the models. Our results in examining the gene expression change in E. coli showed that the non-thermal effects of MWI led to E. coli cells entering the stationary phase with most of the downregulated genes involved in metabolic and …
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The role of prostate cancer microvesicles in epithelial mesenchymal transition
… origin. In this study, I look at the role of PC3 (Prostate Cancer cell line) derived MVs in the induction of EMT in PNT2 (normal prostate) cells. Uptake of PKH26-labelled PC3-derived MVs by recipient cells was greater at a low pH of 5.4 and was dependent on MV-based protein and …
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Investigating Mechanical Strain-Induced Phenotypic Changes on Prostate Cancer Cell Toward Metastasis Using a Three-Dimensional <i>In-Vitro</i> Model
… phenotypic changes in prostate cancer (PC3) cells, progressing cells toward metastasis. A novel mechanical loading platform, the UNIcycler, was developed to apply 1% uniaxial stretch to 3D collagen encapsulated PC3 constructs. In this study, strain was applied for 30 minutes daily for 3 …
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Biological activity of palmitoylcarnitine in prostate cancer
… development. Through the use of cancerous (PC3, DU145) and non-cancerous (PNT1A, BPH) cell models, it was shown that high levels of palcar could induce gene expression of the inflammatory cytokine IL-6, and induce its secretion in PC3 cells. This was associated with the rapid influx of Ca2+. …
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Effect of TIS21 on DNA Damage Repair Induced by Etoposide
TIS21/BTG2/PC3 (12-O-tetradecanoyl phorbol-13-acetate-inducible sequence 21) has been known as a p53 target gene and functions as a tumor suppressor in carcinogenesis of thymus, prostate, kidney, and liver. Although it has been known that the expression of TIS21/BTG2/PC3 was induced during …
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Leukemia/Lymphoma Related Factor in Human Prostate Carcinoma
… cancer cells, LNCaP (androgen sensitive) and PC3 (androgen-insensitive), were used to examine LRF/Pokemon expression by immunocytochemistry and immunofluorescence. The mean immunofluorescence intensity of LRF/Pokemon was significantly higher in PC3 and LNCaP cells than in RWPE-1 cells. Also, …
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THE ROLE OF THE TRANSCRIPTION FACTOR DEAF-1 IN PROSTATE FUNCTION
… basis of DEAF-1 function was studied in PC3 prostate cancer cell line that overexpress epitope tagged DEAF-1. DEAF-1 was upregulated following genotoxic stress like X-ray, ultraviolet radiation, and hydrogen peroxide. Increase in DEAF-1 protein levels could be due to post transcriptional …
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Characterisation of oncogenic pathways driving the pathogenesis of prostate cancer
… of TBX2 via siRNA causes inverse effects in PC3 cells, with upregulation of CST6, NDRG1 and p21WAF1, reducing viability and migration. TBX2 shRNA stable lines were also successfully generated with results mirroring siRNA depletion. Ch-IP qPCR assays confirmed TBX2 binds the promoters of CST6, …
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Transkriptomweite Untersuchungen von Prostata-Krebszelllinien im Kontext medizinischer Strahlentherapie
… wurden vier Prostata-Krebszelllinien (PC3, DuCaP, DU-145, RWPE-1) mit unterschiedlichen Strahlungsempfindlichkeiten kultiviert und auf ihre Überlebensfähigkeit nach ionisierender Bestrahlung durch einen Trypanblau- und MTT-Vitalitätstest geprüft. Die proliferative Kapazität wurde mit …
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Role of Talin1 Phosphorylation In Beta1 Integrin Activation and Prostate Cancer Metastasis
… talin1<sup>S425A</sup> in talin1-silenced PC3-MM2 and C4-2B4 prostate cancer cells decreased β1 integrin activation, adhesion, motility, and increased the sensitivity of cells to anoikis. In contrast, re-expression of the phosphorylation-mimicking mutant, talin1<sup>S425D</sup> led to …
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A computer model for investigating the biomechanical effects of radiation exposure on pathological and non-pathological living human cells
… significant difference for the PNT2 and PC3 cell lines in response to probing with the AFM tip, and that time was eliminated a possible influencing factor in the short term (1 hour) for the force response. Showed that the Hertz model is not sufficient for distances greater than 500nm due …
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Ο ρόλος της θρομβίνης και των υποδοχέων της στην αγγειογένεση και στην ανάπτυξη και μετάσταση του καρκίνου
… Στις σειρές από καρκίνο του προστάτη PC3 και LNCaP και στις σειρές από καρκίνο του μαστού MDA-231 και MCF-7. Η διερεύνηση της λειτουργικότητας του παραπάνω υποδοχέα στις προαναφερθείσες σειρές και το αποτέλεσμα της αναστολής του υποδοχέα στην επιβίωση και στον πολλαπλασιασμό των …
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Characterization of Metastasis-Associated Cell Surface Glycoproteins in Prostate Cancer
… on a human syngeneic PCa cell metastatic model, PC3 and its two variants with different metastatic potentials. It was found that metastatic potentials of PC3 variants were inversely correlated with cell surface α2-6 sialic acid levels. Targeted to cell surface sialoglycoproteins, a new …
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Androgen receptor-mediated growth suppression and apoptosis of human prostate epithelial cells
… epithelial cell lines (HPr-1AR, RWPE-AR and PC3-Lenti-AR) under optimized or stressed conditions, identified androgen-responsive genes that restrain cell cycle progression or mediate programmed cell death, and defined mechanisms whereby AR regulates their expression. Here, we report the …
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