Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"PC12 cell"”.
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NADPH oxidase in PC12 cell differentiation and apoptosis
… the common factor leading to neuronal death. PC12 cells differentiate into sympathetic-like neurons in the presence of nerve growth factor (NGF). Once terminally differentiated, PC12 cells undergo apoptosis following NGF deprivation with similar characteristics of sympathetic neuronal death. …
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Type I PIP5Kα negatively regulates NGF-induced neurite outgrowth in PC12 cells
… outgrowth. For this, I generated a stable PC12 cell line lacking PIP5KIa by microRNA (miRNA) expression, leading to decreased PtdIns(4,5)P2 level. Results show that neurite outgrowth induced by nerve growth factor (NGF) was more prominent in PIP5KIa-deficient cells than in control …
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Effects of tumor necrosis factor alpha on nitric oxide synthase in nerve growth factor-responding cells
… oxide synthase (NOS), in rat pheochromocytoma PC12 cells. NGF/TNFa-promoted iNOS can be toxic in PC12 cells. Using PC12 cell mutants lacking the low affinity p75NTR receptor, we also demonstrate that this receptor is required to mediate iNOS expression, likely acting through the transcription …
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COMBINATORIAL DEVELOPMENT OF NANOSTRUCTURED MATERIAL LIBRARIES FOR THE STUDY OF CELL SUBSTRATE INTERACTION
An in vivo cellular microenvironment in which cells are immobilized contribute an essential role in diverse cellular behavior, consisting of cellular morphology, dynamics and eventually cellular fate. Micro and nanofabrication tools widely used to mimic the in vivo surrounding to manipulate …
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The Role of Advanced Glycation End Products (AGEs) through the TRPA-1/NRF-2 Activation Pathway in the Neurodegenerative Diseases
… formation and accumulation of AGEs in different cell types affect intracellular and extracellular structure and function. AGEs can also cause macrovascular and microvascular complications through the formation of cross-links between key molecules, permanently altering cellular structure …
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Pheochromocytoma-induced cardiomyopathy : a model of synergistic effects of multifactorial tumor secretions
… by catecholamine-secreting pheochromocytoma cells. Pheochromocytomas are widely believed to induce cardiomyopathy via hypersecretion of catecholamines including norepinephrine (NE). NE can have direct cardiomyocyte toxicity and can stimulate myocardial remodeling secondary to the induction of …
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COMPOSTI AD AZIONE ANTI-AGGREGANTE ESERCITANO UN EFFETTO BENEFICO SU MODELLI CELLULARI DI ATROFIA MUSCOLARE SPINALE BULBARE
… brainstem and cause the death of those specific cell populations. AR belongs to the nuclear hormone receptors superfamily and it works as a transcriptional factor after binding its specific ligand (testosterone or dihidrotestosterone) in the carboxyl-terminal ligand-binding domain (LBD). The …
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ASSESSMENT OF CELL AND METABOLIC IMPACT OF MICROTUBULE TARGETING AGENTS (MTA) IN NEURODEGENERATION AND NEURON MODELS.
… Metabolic Models (GSMM) we report that, in PC12 cell model, neuronal differentiation is accompanied by switching towards a more glycolytic metabolism, with the glucose catabolism that tends towards lactate production, rather than the aerobic oxidative pathway, with a general reduction of TCA …