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Showing 1 to 20 of 67 for “"PC12"”.

  1. Molecular regulation of neuronal apoptosis in PC12 cells.

    Sridhar, Srikala.University of Ottawa (Canada)2009

    In this study apoptosis was induced in neuronal PC12 cells by 2-5 $\mu$M VM26 (teniposide, a known apoptotic inducer) and changes in the expression of genes considered to be involved in apoptosis were examined by RT-PCR. Cell death, DNA fragmentation and morphological changes associated with …

    ottawa-retro Repository record

  2. NADPH oxidase in PC12 cell differentiation and apoptosis

    Begdache, Lina2016

    … the common factor leading to neuronal death. PC12 cells differentiate into sympathetic-like neurons in the presence of nerve growth factor (NGF). Once terminally differentiated, PC12 cells undergo apoptosis following NGF deprivation with similar characteristics of sympathetic neuronal death. …

    binghamton Repository record

  3. Regulation of n-3 PUFA biosynthesis in proliferating and differentiated PC12 pheochromocytoma cells

    Msika, OraLondon Metropolitan University2012

    … in proliferating and NGF-differentiated PC12 pheochromocytoma cells deficient in n-3 docosahexaenoic acid (DHA, 22:6n- 3) was studied. A dose- and time dependent increase in eicosapentaenoic acid (EPA, 20:5n-3), docosapentaenoic acid (DPA, 22:5n-3) and DHA in phosphatidylethanolamine …

    london-metro Repository record

  4. The crosstalk between the ERK and the cAMP signalling pathways in PC12 Cells

    Gormand, AmelieUniversity of Glasgow2008

    … survival, proliferation and differentiation. In PC12 cells, the ERK signalling pathway integrates different external stimuli: epidermal growth factor (EGF) stimulates the ERK pathway transiently and induces cell proliferation, whereas nerve growth factor (NGF) induces sustained activation of ERK …

    glasgow Repository record

  5. Investigating Isoform-specific of Apolipoprotein E on the Neuronal Differentiation of PC12 Cells

    Cunningham, Michaela

    bridgewater Repository record

  6. Type I PIP5Kα negatively regulates NGF-induced neurite outgrowth in PC12 cells

    Liu, Tian2011

    … outgrowth. For this, I generated a stable PC12 cell line lacking PIP5KIa by microRNA (miRNA) expression, leading to decreased PtdIns(4,5)P2 level. Results show that neurite outgrowth induced by nerve growth factor (NGF) was more prominent in PIP5KIa-deficient cells than in control …

    ajou Repository record

  7. Effects of nerve growth factor on TGF-Beta,Smad signal transduction in PC12 cells

    Lutz, MarionUniversität Würzburg

    … is characterized in rat pheochromocytoma cells (PC12) which are frequently used as a model system for neuronal differentiation. PC12 cells were found to be unresponsive to TGF-ß due to limiting levels of TßRII. However, stimulation with NGF results in initiation of Smad-mediated transcription …

    wurz-thes Repository record

  8. The establishment and characterization of an improved cell-free assay for exocytosis in neuroendocrine PC12 cells

    Barszczewski, Marcin Miroslaw2012

    … beschichteten Objektträgern wachsende PC12-Zellen wurden durch einen Ultraschallpuls in einer kleinen Kammer direkt auf dem Objekttisch eines Fluoreszenzmikroskops aufgeschlossen. Durch Ca2+ konnten eGFP-beladenen Vesikel der so hergestellten "membrane lawns" zur Exozytose und damit zur …

    goettingen Repository record

  9. The role of rab3b and phosphatidylinositide 3-kinase in the regulation of norepinephrine uptake by PC12 neuroendocrine cells.

    Francis, Sharon Cheryll

    uab Repository record

  10. Pheochromocytoma-induced cardiomyopathy : a model of synergistic effects of multifactorial tumor secretions

    Mobine, Hector RMassachusetts Institute of Technology2009

    … a polymeric cell encapsulation system to control PC12 cell kinetics and NE release in vitro and in vivo. We demonstrated that pheochromocytoma-conditioned media induced greater cardiomyocyte contractility and cytoskeletal remodeling than NE alone. We next examined the cardiomyopathy development in …

    mit Repository record

  11. Expression and Requirement of Epithelial Fatty Acid- Binding Protein in Neuronal Axon Growth

    Allen, Gregory William

    … test this hypothesis, E-FABP expression in both PC12 cells and primary retinal neurons was examined. In PC12 cells, NGF induces E-FABP mRNA and protein during the period of neurite outgrowth, and E-FABP localizes to the perinuclear cytoplasm, nucleus, and growth cone. Furthermore, …

    loma-linda Repository record

  12. Effects of tumor necrosis factor alpha on nitric oxide synthase in nerve growth factor-responding cells

    Michael ThomasThe University of Texas Medical Branch2005

    … oxide synthase (NOS), in rat pheochromocytoma PC12 cells. NGF/TNFa-promoted iNOS can be toxic in PC12 cells. Using PC12 cell mutants lacking the low affinity p75NTR receptor, we also demonstrate that this receptor is required to mediate iNOS expression, likely acting through the transcription …

    utmb Repository record

  13. MacMARCKS and the Protein Kinase C Signal Transduction Pathway: Role in Neural Secretion and Neural Development

    Chang, Sandy

    … manner in rat brain synaptosomes and PC12 cells. It is localized to cell bodies and neurite tips of PC12 cells as well as being present on synaptic vesicles. A dominant-negative mutation in the MacMARCKS effector domain which abolishes PKC-dependent phosphorylation is associated with …

    rockefeller Repository record

  14. Association of NGF receptors with membrane rafts in PC12 cells : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University

    Clements, Shona Marie2001

    massey

  15. Zinc ion homeostasis in cellular physiology and experimental models of traumatic brain injury

    Yuan LiThe University of Texas Medical Branch2009

    … and differentiated rat pheochromocytoma (PC12) cells and in rat glioma (C6) cells. When PC12 cells proliferate, [Zn2+]i undergoes precisely controlled fluctuations with two peaks within one cell cycle. These results demonstrate that the already established requirement for zinc in the cell …

    utmb Repository record

  16. COMBINATORIAL DEVELOPMENT OF NANOSTRUCTURED MATERIAL LIBRARIES FOR THE STUDY OF CELL SUBSTRATE INTERACTION

    V.K. SharmaUniversità degli Studi di Milano2014

    … was investigated by contact angle measurements. PC12 cells derived from a Pheochromocytoma of the rat adrenal medulla were cultured on five different morphologies in presence of nerve growth factor (NGF) and the results suggest that the increasing roughness not only diminishes cellular attachment …

    milano Repository record

  17. Neuroprotective Effects of FGF20 on Dopamine Neurones

    Boshoff, EugeneKing's College London2012

    … ERK1/2 activation and neurite outgrowth in PC12 cells. It was demonstrated here that agrin potentiates FGF20 stimulated ERK1/2 activation, but it fails to potentiate FGF20’s neuroprotective effects in PC12 cells.

    kings Repository record

  18. Halting the neural progression of cancer

    Kamath, Annika2024

    … vitro, SEMA3F-induced repulsion was observed in PC12 and U87MG cells, which express NRP2. SEMA3A also successfully repelled SY5Y cells, which express NRP1. Neurite length was significantly inhibited by SEMA3F in PC12 and U87MG neurite outgrowth assays. Taken together, our results suggest that …

    bu Repository record

  19. Newly Synthesized Pyroglutamate Amide and its Neuroprotective Effect Against Neurotoxicity Induced Cell Death in Alzheimer's Disease

    Elamrani, Nourelhouda JouteyThe Graduate School and University Center of The City University of New York2024

    … NSP has more potent effect in inhibiting N2a and PC12 cells than the potent effect of mem due to the amide function in NSP. We also demonstrate that NSP has an inhibitory effect at a great extent on glutamate induced N2a and PC12 cells death. The inhibition of the activity of glutamate was shown …

    cuny-grad Repository record

  20. The identification of NRAGE

    Jordan, BruceUniversität Würzburg

    … and the NGF mediated differentiation in PC12 cells, a two hybrid screen was performed with a PC12 library using ITA as a bait. The screen resulted in the identification of several overlapping fragments of a previously unknown gene. The complete cDNA for this gene was isolated, the …

    wurz-thes Repository record

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