Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"PBX1"”.
-
Molecular analysis of transcriptional properties of Pbx1 and E2a-Pbx1
E2a-Pbx1 is an oncogene formed by the t(1;19) chromosomal translocation, which is found in 20% of pediatric pre-B acute lymphoblastic leukemias. E2a-Pbx1 joins exons encoding the amino-terminal transactivation domain of E2a with those encoding the carboxyterminal homeodomain of Pbx1, which binds …
-
Examining the effect of CBP on the E2A-PBX1 and HOXB4 interaction
The E2A-PBX1 fusion gene results from the t(1;19) chromosomal translocation that is found in 25% of pre-B-cell cases of acute lymphoblastic leukemia (ALL). The resulting encoded product contains the transactivation domains of E2A, a Class I basic helix-loop-helix transcription factor, and most of …
-
Neuronale in-vitro Differenzierung von murinen homozygoten Pbx1 Knock-out embryonalen Stammzellen : ein System zum Studium der Funktion und zur Identifikation potentieller Zielgene des Pbx1-Homeoboxproteins während der zellulären Differenzierung
Die Expression des PBX1-Gens ist essentiell für die normale Embryogenese. PBX1-knock-out-(K.O.)Mäuse sterben früh während der embryonalen Entwicklung mit einer Aplasie und Hypoplasie multipler Organsysteme. Dies verhindert eine detaillierte Analyse des Effektes eines PBX1-K.O.s auf die neuronale …
-
Characterization of Transcription Factor-Coactivator Complexes in Acute Lymphoblastic Leukemia
… cases, the oncogenic transcription factor E2A-PBX1 is expressed as a result of the chromosomal translocation 1;19. E2A-PBX1 contains the activation domains of E2A and most of the PBX1 protein, including the DNA-binding homeodomain. These structural features suggest a hypothetical oncogenic …
-
Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor
… of the oncogenic transcription factor, E2A-PBX1. Although t(1;19) is exclusively associated with pre-B ALL in clinical cases, murine models produce myeloid or T-lymphoid leukemias, which are not representative of the clinical disease. In this work, we have advanced progress towards the …
-
Single-cell approaches reveal functional and molecular heterogeneity in malignant haematopoietic stem cells
… HSCs. Of these, Bmi1 and, to a lesser extent, Pbx1 and Meis1 overexpression in JAK2-mutant HSCs could improve stem cell self-renewal, allowing development of a disease phenotype in functional assays. Together, these findings refine the molecules involved in clonal expansion of MPNs, and …
-
Cre-lox-basierte Inaktivierung des Pbx3-Gens
… seiner ausgeprägten Homologie zum Proto-Onkogen Pbx1 isoliert wurde. Zusammen mit einer Untergruppe von Homöodomän-Proteinen bindet es mit für die Entwicklung der Säugetiere unbekannten Konsequenzen in hochmolekularen Komplexen an die DNA. Die Beteiligung des Pbx3-Proteins an der Regulation der …
-
Role of ASCL1 and Its Interactors in Neuroblastoma
… during development, such as BCL11B, PBX1, PHOX2B, SOX11, and others. On the other hand, in the cell lines less responsive to ASCL1-induced differentiation, ASCL1 associated more with proteins involved in cell-cycle regulation, such as CDKs and cyclins, or showed weaker association …
-
Self-assembling amphiphilic peptides: A novel approach to create new drug systems and three-dimensional scaffolds for tissue regeneration. A resourceful mine not yet fully explored
… This peptide works as an inhibitor of the HOX-PBX1 interaction. HOX and PBX I are two transcription factors that are deeply involved in the DNA regulation during embryogenesis and they are found to be highly miss-regulated in several types of cancers. Until now, peptide amphiphiles have been …
-
The Role of Meis1 in Hematopoietic Development
… forms a heterodimer with Pbx1 that augments Hox-dependent gene expression. In addition, <italic>Meis1</italic> has been associated with leukemogenesis and hematopoietic stem cell self-renewal. In examining potential roles of <italic>Meis1</italic> in hematopoietic …
-
Pax5 Haploinsufficiency Cooperates with BCR-ABL1 to Induce Acute Lymphoblastic Leukemia
… the t(9,22)[<em>BCR-ABL1</em>], t(1,19)[<em>TCF3-PBX1</em>], t(12,21)[<em>ETV6-RUNX1</em>], <em>MLL</em>rearranged leukemia’s, hyperdiploid and hypodiploid karyotypes, and T-lineage leukemia. Each translocation confers a characteristic transforming phenotype within the cell in which it originates …