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Showing 1 to 2 of 2 for “"PBTK"”.
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Model-based Exploration of Chemical Absorption and Metabolism Kinetics in the Human Gastrointestinal Tract
… Therefore, a physiological-based toxicokinetic (PBTK) model is built to understand the potential of chemicals to undergo pre-systemic metabolism, especially in the human gut lumen. The results show that gut lumen metabolism can significantly reduce the Fbio of CECs, for instance, by more than 80% …
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Computergestützte Analysen in der Toxikologie
Im Rahmen der EU-weiten REACH-Verordnung haben Alternativmethoden zum Tierversuch in der Toxikologie an Bedeutung gewonnen. Die Alternativmethoden gliedern sich auf in In-vitro- und In-silico-Methoden. In dieser Dissertation wurden verschiedene Konzepte der In-silico-Toxikologie behandelt. Die …