Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 135 for “"PBMC"”.
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Expression und Regulation des antimikrobiellen Cathelicidin-Peptids LL-37 in humanen Kolonepithelzellen, Monozyten und PBMC
… mit SCFAs beobachtet werden. Bei reifen PBMC jedoch inhibiert Butyrat eine LL-37 Transkription. In nicht differenzierten Monozyten blockt ein MEK/ERK-Hemmer die LL-37 Expression wie in Kolonepithelzellen, dagegen hat diese Blockade in reifen PBMC keine Auswirkung auf die LL-37 …
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Einfluss von septischem Plasma und intensivmedizinischen Medikamenten auf die Zytokin- und Procalcitoninfreisetzung von in vitro stimulierten PBMC septischer Patienten und immunkompetenter Probanden
In der vorliegenden Arbeit wurde der Einfluss von verschiedenen in der Intensivtherapie der Sepsis etablierten Medikamenten auf die peripheren mononukleären Zellen gesunder Probanden und septischer Patienten untersucht. Als ein weiteres Ziel untersuchten wir, ob Plasma, das von septischen Patienten …
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Characterization of Variable Region Structures and Antigen-Binding Properties of OxLDL-Specific Human Monoclonal Antibody Isolated from PBMC and Atherotic Plaques of Atherosclerosis Patients
… isolated from atherosclerosis patients' PBMC; second, determination of the VH and VL sequences of the Fab produced from the plaques and comparison them with those from PBMC. This study will improve the knowledge of the mechanism which are related to the pathogenesis of atherosclerosis and …
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Compartmental Hepatitis B Virus (HBV) Evolution, Replication and Infectivity in vivo and ex vivo
… plasma and peripheral blood mononuclear cell (PBMC)) is unknown, as well as the replicative competence and infectious capacity of PBMC-derived HBV. We hypothesize that HBV replicating in lymphoid cells is infectious, and the HBV evolves in PBMC and/or plasma in chronic hepatitis B (CHB) …
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Biomarkers and cell phenotypes in TB patients with minimal or persisting lung inflammation post-anti-TB treatment and ex-vivo atorvastatin immunomodulatory effects on M. tuberculosis-infected PBMC
Unresolved lung inflammation post-anti-TB treatment necessitates the evaluation of additional host-directed therapies (HDT). Statins, recognized for their pleiotropic effects, show potential as immunomodulators to reduce post-TB lung inflammation. The ongoing StatinTB clinical trial utilizes a …
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Contribution à la compréhension de l'immunopathogénie de l'aspergillose nasosinusale chez le chien
… (IL-17A and RORc) and Treg (IL-10 and FoxP3) in PBMC of affected and healthy dogs after A. fumigatus stimulation. Secondly, an analysis of genes by microarray has been carried on nasal mucosa biopsies of affected and healthy dogs. Thirdly, the promotor zone of the gene encoding IL-10 in dogs has …
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Genetic diversity of subtype C HIV-1 env variants in peripheral blood mononuclear cell (PBMC) DNA from infected mother-child pairs : a comparison of Heteroduplex Mobility Assay (HMA) and Base Excision Sequence Scanning (BESS) methods
… variants in peripheral blood mononuclear cells (PBMC's) derived from infected mother-child pairs. Two methods for displaying DNA differences were compared: I-leteroduplex Mobility Assay (I-IMA) and Base Excision Sequence Scanning (BESS). These methods were validated using sequence data. Extracted …
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A NOVEL PIPELINE FOR DRUG DISCOVERY IN NEUROPSYCHIATRIC DISORDERS USING HIGH-CONTENT SINGLE-CELL SCREENING OF SIGNALLING NETWORK RESPONSES EX VIVO
… networks at the single-cell level in distinct PBMC subtypes ex vivo. Using automated sample preparation, fluorescent cellular barcoding and flow cytometry the platform is capable of detecting 21, 840 parallel cell signalling responses in each PBMC sample. We apply this platform to characterize …
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EVIDENCE SUPPORTING THE UTILITY OF BLOOD CELL RESPIRATORY CAPACITY AS A SYSTEMIC MARKER OF MITOCHONDRIAL HEALTH AND BIOLOGICAL AGE
… in older adults, and responds to intervention. PBMC and platelet respiration produced similar respiratory rates over 1 week with intraclass correlation coefficients greater than 0.5. Platelet and monocyte bioenergetics associated with bioenergetics of skeletal and cardiac muscle, and PBMC …
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In vitro evaluation of equine bone-marrow derived mesenchymal stromal cells to combat orthopedic biofilm infections
… cytokines by peripheral blood mononuclear cells (PBMC) and by secreting SPM. MSC demonstrated partial ability to reduce biofilms but performed differently on S. aureus versus E. coli biofilms. Co-culture of biofilms with MSC significantly reduced pellicle area of biofilms of both bacteria, reduced …
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Polyunsaturated fatty acids and immune cell functions
… effects of n-6 and n-3 PUFAs on normal healthy PBMC production of TGF-ß1 in vitro showed that PBMC in the presence of phytohaemaglutinin (PHA) supplemented with LA, dihyomo-?-linolenic (DGLA) and arachidonic acid (AA) significantly increase TGF-ß1 compared with non-supplemented PHA-stimulated …
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Predicting the risk of progression in patients with thoracic aortic aneurysm
… a unique dataset quantifying plasma proteins and PBMC-RNAs in a cohort of 50 AD patients with measurements of growth or clinical progression over 2 years. Analysis of my dataset indicates that: a) aortic size alone is not a good predictor of growth b) prediction of future growth can be improved by …
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Vorläuferzellen des lymphatischen Endothels
… wurden mononukleäre Zellen aus peripherem Blut (PBMC) von Kindern untersucht. In Analogie zu den Lymphangioblasten in Mausembryonen, wiesen Subpopulationen der PBMC charakteristische Marker von Lymphendothelzellen auf. RNA-Expressionsstudien bestätigten diese Resultate. Molekulargenetische …
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Immune Regulatory Role of Human CD141+ Dendritic Cells in Humanised Models of Alloimmunity
… human peripheral blood mononuclear cells<br/>(PBMC; “Hu-PBMC mice”) are important tools to study human immune function in<br/>vivo. The recent introduction of targeted deletions at the interleukin-2 common gamma chain (IL-2R!null), notably the NOD-scid IL-2R!null (NSG) and BALB/c-Rag2null …
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Untersuchungen zur Assoziation genetischer Polymorphismen im Gen des Endotoxinrezeptors CD14 mit der transkriptionellen Aktivität
… des CD14-Gens wurden die CD14-mRNA-Menge in PBMC und die sCD14-Serumkonzentration herangezogen. Als Ausgangsmaterial dienten Blutproben von 42 gesunden Probanden und 42 Patienten mit chronischer Hepatitis C. Des Weiteren standen Lebergewebeproben von 41 chronisch HCV-infizierten Patienten zur …
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Die Bedeutung von Zinkionen für mononucleäre Leukocyten
… main zinc transporter in monocytes, T-cells and PBMC, whereas hZIP1 is the highest expressed zinc transporter in B-cells. hZIP2 was only detectable at a very low level in all examined cells. All three transporters were upregulated in response to zinc deprivation. The assessment of transporter …
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MxA-Genexpression in peripheren mononukleären Blutzellen: ein sensitiver Marker für die Aktivität von endogenem und exogenem Typ-I-Interferon
… MxA mRNA in peripheren mononukleären Blutzellen (PBMC) zu bestimmen. In verschiedenen Zellsystemen konnte gezeigt werden, dass die MxA-Genexpression mit der IFN-alpha-Aktivität auch bei geringsten IFN-Mengen korreliert. Daraufhin wurde die MxA-Genexpression in PBMC von Patienten mit …
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Mental health and asthma control during pregnancy: investigating underlying immune mechanisms
… (FACS) and peripheral blood mononuclear cell (PBMC) chemotaxis was also examined. Results: The incidence of uncontrolled asthma increased in women with depression/anxiety compared to women without depression/anxiety during pregnancy (unadjusted incidence rate ratio (IRR) 1.739, adjusted IRR …
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NUTRITION AND IMMUNITY: MOLECULAR APPROACHES
… on bovine peripheral blood mononuclear cells (PBMC) revealed that CLA (50:50) mixture does modulate bovine PBMC proteome, supporting the antiapoptotic and immunomodulatory effects observed in the previous in vitro study on bovine monocytes, and propose a potential cytoprotective role of CLA …
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Salmon in Pregnancy Study (SIPS): the effects of increased oily fish consumption on maternal nutrient intake, fatty acid status and immunity
… plasma, peripheral blood mononuclear cell (PBMC), placenta nad umbilical cord tissue fatty acid compositions were determined by gas chromatography (GC). Maternal immune cell subsets were determined by flow cytometry (FACS); ex-vivo cytokine production by PBMC in response to stimulants …
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