Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"PBD"”.
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A new approach in blade shape adjustment in PBD-14 design mode
… for marine propulsors developed at MIT, known as PBD-14. The algorithm for adjusting the blade shape in the current version of PBD-14 works satisfactorily in most cases. However, with more complex schemes such as ducted propulsors and/or higher load distributions, the process has to be carefully …
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On the discovery and biological characterization of porcine β-Defensin 5 (pBD-5)
… peptides (HDPs), such as porcine β-defensins (pBDs), have gained attention for their immunomodulatory, microbiome-modulating, and antimicrobial properties. This thesis describes the discovery, synthesis, and biological characterization of a novel porcine β-defensin, pBD-5, and its role in …
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European Privacy by Design
… the concept of European Privacy by Design (PbD): laws and regulations, business goals and architecture designs. These forces carry their own influence in terms of ethics, economics, and technology. In this research we undertook the journey to understand the concept of European PbD. We …
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The Structural and Functional Study of GIT1 Paxillin Binding Domain
… between its C terminal paxillin-binding domain (PBD) and the LD motifs of paxillin. <br /><br />In this dissertation, we determined the solution structure of rat GIT1 PBD by nuclear magnetic resonance (NMR) spectroscopy. The PBD folds into a four-helix bundle, which is structurally similar to the …
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Intra-operative Prophylactic Pyloric Balloon Dilatation During Oesophagectomy to Prevent Early Delayed Gastric Emptying
… leak and pneumonia. Pyloric balloon dilatation (PBD) is a recognised treatment of this complication. Preventative measures such as pyloroplasty, pyloromyotomy and pyloric Botox® injection have all been employed. Recent data however suggest none of these treatments have a significant effect in …
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Development of Fragility Curve Database for Multi-Hazard Performance Based Design
… efficient multi-hazard performance based design (PBD) tools to analyze and optimize buildings at a preliminary stage of design. The first step was to develop a database and it is supported by five major contributions: 1) development of nomenclature of variables in PBD; 2) creation of mathematical …
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Development of Non-Atp Competitive, Plk1-Selective Inhibitors
… By targeting the non-catalytic polo box domain (PBD) of PLK1, which modulates sub-cellular localization and mitotic functions of PLK1, we can obtain selective PLK1 inhibition, which can lead to mitotic arrest and inhibit tumor cell proliferation. The structure-guided discovery strategy called …
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Nanoscale Organization of The Small Gtpase Rac1
… palmitoyl, and a polybasic domain (PBD) of contiguous lysine and arginine residues. Using high-resolution imaging combined with spatial mapping analysis, I found that Rac1 forms nanoclusters on the PM. Cycling between the GTP- and GDP-bound states, Rac1 forms nanoclusters that are …
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Pharmacological characterisation of selected pyrrolobenzodiazepines as anti-cancer agents. Pharmacokinetic and pharmacodynamic characterisation of the pyrrolobenzodiazepine dimer SJG-136 and the monomers D709119, MMY-SJG and SJG-303
… pharmacology of selected pyrrolobenzodiazepine (PBD) compounds shown to have cytotoxic activity with predicted DNA sequence selectivity. Research focused upon the PBD dimer, SJG-136, selected for clinical trials, and the novel PBD monomer compounds D709119, MMY-SJG and SJG-303. SJG-136, a novel …
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3D mathematical model of the hyoid bone and attached muscles during swallowing
… muscles (SM), posterior belly of digastric (PBD), and infra-hyoid muscles (IH) were measured. The anterior and posterior boundaries of upper esophageal sphincter (UES) and the antero-inferior corner of cervical vertebrae 7 (C7) were also measured. The soft tissue between the hyoid bone and …
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Pneumatic balloon dilatation versus laparoscopic Heller's myotomy in idiopathic achalasia
… myotomy (LHM) and pneumatic balloon dilatation (PBD) are widely used in the management of achalasia, but there is still no clarity as to which of these interventions is the best treatment for patients with the condition. Methods Newly diagnosed achalasia patients were randomised into PBD or LHM. …
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Incorporating Recycled Plastics in Asphalt Binders and Mixtures
… with polyisoprene (PI) and polybutadiene (PBD) backbones synthesized with polyethylene-block-polyethylene (glycol) (PEPEG) at two different molecular weights were tested. The effect of unreacted Maleic anhydride (MAH) in the compatibilizers was also evaluated.Polyisoprene (PI) and …
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High-Throughput Measurements of Thermal Conductivity and the Coefficient of Thermal Expansion
TDTR and TD-PBD are used to study the local properties near the dentin-enamel junction (DEJ) in a human tooth. The thermal conductivity and Young's modulus are uniform in dentin and enamel, respectively, and change abruptly across the dentin-enamel interface. The CTE changes gradually in dentin …
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Thermodynamic Interactions in Polydiene/Polyolefin Blends
… in this study include a series polybutadienes (PBD) with varying amounts of 1,2 and 1,4 microstructure units and 1,4-polyisoprene (1,4-PI); the corresponding polyolefins included are poly(ethyl ethylene) (PEE), polyethylene (PE), PE-co-PEE random copolymers, and poly(ethylene-alt-propylene) …
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Porous Carbon Fiber Functionalization and Thermochemical Degradation of Polystyrene-based Plastics for Resource Recovery
… two other polymer blocks, PS and polybutadiene (PBD), which make the degradation pathway more complicated. Under similar conditions of PS degradation using AlCl3, the benzene yield was lower in ABS degradation. Size exclusive chromatography (SEC) analysis revealed the incomplete degradation with …
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Assessing the role of Hsp70 in prion propagation in Saccharomyces cerevisiae
… ATPase domain, a peptide-binding domain (PBD) and a C-terminal domain. In this study we describe a genetic screen that identifies an array of mutants within different domains of the major cytosolic Hsp70 chaperones of yeast, Ssa1-4 which impair the propagation of [PSI+]. A majority of …
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Performance based wind design and optimization of tall buildings considering the nonlinearity in building response
… tall buildings such as Performance-Based Design (PBD). PBD has become a mainstream approach to assess and reduce the risks in rehabilitation of existing structures. Application of PBD philosophy for design of tall buildings and other structures excited by wind loads has received much attention …
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Fire engineering in sustainable buildings: An Evaluation for the application of Performance Based Design in Abu Dhabi
… challenges with performance-based designs (PBD) in buildings are also part of this study. It also investigated current practices in sustainable building design and fire safety measures applied by Abu Dhabi Civil Defence (ADCD) under the existing construction legislations. The overall results …
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Structural and morphological characterization of model elastomeric ion containing polymers
… on either a polyisoprene (PIP) or polybutadiene (PBD) backbone. The PIP ionomers have been neutralized with various cations and neutralized to different levels. The bulk properties were found to be highly dependent on the nature of the cation, its valency, and its ionic radius. A series of …
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Protein potentials and domains : re-use and composability
… domains, known as peptide-binding domains (PBD), that play a particularly crucial role in mediating protein-protein interactions. Using these components as a basis, we develop a model for protein-protein interactions driven by PBDs. Our approach revises a previously proposed model, both …
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