Global ETD Search
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Showing 1 to 4 of 4 for “"PAXX"”.
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An exploration of the interplay between HSV-1 and the non-homologous end joining proteins PAXX and DNA-PKcs
… (DNA-PKcs) and paralogue of XRCC4 and XLF (PAXX). PAXX was first described in the literature as a NHEJ protein in 2015, but whether it has any role in the regulation of virus infection has not been established. Here we show that PAXX acts as a restriction factor for HSV-1 because PAXX-/- …
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Investigating the regulation of DNA non-homologous end-joining through Ku70/80 interacting factors
… site on the protein paralog of XRCC4 and XLF (PAXX). As PAXX is a Ku interactor with a role in NHEJ, the effect of PAXX phosphorylation is investigated as a potential NHEJ regulatory system. Lastly, I investigate the role of the RecQ helicase WRN, whose precise roles in the DDR are unclear. As …
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DNA-PKcs/ Artemis Complex in DNA Double-Strand-Break Repair: Cryo-EM and Biochemical Studies
… method, which identified the function of PAXX as an early participating component in end synapsis.
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Cryo-EM as a Tool to Study the Diverse Interactome of Ku 70/80 in NHEJ and Beyond
… the accessory factor Paralog of XRCC4 and XLF (PAXX) and other revealing the dimeric arrangement of NHEJ processing enzymes as DNA polymerase λ. Through collaborations with external academic and industrial partners, the importance of the identified interactions was further confirmed using …