Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"PAX8"”.
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Mise en évidence et caractérisation de l'intéraction entre PAX5 et PARP-1
… donné la similarité structurale entre Pax5 et Pax8. Une fois cette interaction établie, on sera en mesure de caractériser cette dernière et de déterminer son implication dans un contexte oncogénique".--feuille v.
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SMARCB1 Maintains Lineage Fidelity in Clear Cell Renal Cell Carcinoma
… inhibition of the essential renal lineage factor PAX8. SMARCB1 knockout (KO) leads to large-scale loss of a kidney-specific enhancer program, conversion to a cellular state resembling that of rhabdoid tumours, and the re-activation of proliferative pathways. Using a second CRISPR/Cas9 screen, I …
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Identifying the Origin of Zebrafish (Danio rerio) Renal Progenitor Cells
… early-acting renal genes (such as pax2a and pax8) in both single RPCs and cluster RPCs. Later acting renal genes (such as hnf1ba) were predominantly expressed in the cluster RPCs, supporting the concept that these cells are more mature. Surprisingly, the analysis also revealed a number of …
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IMPACT OF KETOGENIC DIET TREATMENT IN GLUT1 DEFICIENCY SYNDROME: DISCOVERY OF MOLECULAR MECHANISMS RESPONSIBLE FOR PHENOTYPE CHANGES IN BOTH PEDIATRIC AND ADULT PATIENTS
… risposta infiammatoria. Altri lncRNAs, come PAX8-AS1, sono stati correlati alla biosintesi dei chetoni e ai processi di fosforilazione ossidativa, suggerendo un potenziale ruolo regolatorio nella risposta alla KD. L’analisi delle isoforme di splicing alternativo ha evidenziato un ulteriore …
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DNA methylation variability at the crossroads of stochasticity, genetics, and environment
… that at a variably-methylated promoter of the PAX8-AS1 lncRNA gene, nearby genetic variants could restrict population-level methylation variability: individuals homozygous for the minor allele (haplotype) were all fully methylated while there was a wide range of methylation states among …
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A mouse model to study inducible oncogene cooperation <i>in vivo</i>
… development of the thyroid;<br></br><br></br> 2. Pax8Cre, in which the Cre sequence is inserted in the Pax8 locus and is expressed during the early stages of the thyroid development.<br></br><br></br> In such a manner the oncogenes were expressed only in thyroid cells, but were still …
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Development and evaluation of methodologies for analysis of CTC and ctDNA in patients with ovarian carcinoma
… EpCAM), mesenchymal (vimentin), and OC specific (PAX8) markers for detection of CTCs (Chapter 3). CD45/16 and CD31 were used for the exclusion of white blood and vascular endothelial cells, respectively. PD-L1 was used for CTC characterisation. Optimisation of the CTC markers were done using OC …