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Showing 1 to 20 of 51 for “"PAX6"”.
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Bedeutung der Homöodomäne des Transkriptionsfaktors Pax6 für die Aktivierung des Glukagon-Gens durch Pax6
Pax6 ist einer der essentiellen Transkriptionsfaktoren zur Aktivierung der Glukagon-Genexpression und enthält zwei DNA-Bindungsdomänen, die Paired-Domäne und die Homöodomäne. In vitro bindet Pax6 über seine Paired-Domäne an das proximale Promotorelement G1 und an Domäne A des mehr distalen …
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Regulatory architecture of the Pax6 locus
Pax6 is a highly conserved developmental regulator with a complex temporal, spatial and quantitative expression pattern, that is crucial for correct development of the central nervous system, the eye, and pancreas. Accordingly, the Pax6 gene resides in a complex genomic locus containing a large …
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Regulation of PAX6: DNA methylation and MicroRNAs
The Paired box gene 6 (PAX6) is a tissue-specific transcription factor, which controls proliferation and differentiation processes of embryonic- and adult progenitor cells. Consequently, dysregulation of PAX6 can cause cancer and a tight regulation is essential. The present thesis focuses on two …
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The Role of Pax6 in Lens Placode Formation
THE ROLE OF PAX6 IN LENS PLACODE FORMATION by Jie Huang Washington University in St. Louis, 2010 Professor David Beeebe, Chairperson Although placodes are ubiquitous precursors of tissue invagination, the mechanism of placode formation and its importance for invagination are unclear. We tested the …
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Transcription factor Pax6 protects mouse cortical cell fate specification
… expression of transcription factors (TFs). Pax6 is one of such TFs. Importantly, it is expressed strongly in the PC dorsal Emx1 lineage but much less so or not at all in interneuron ventral lineages. Here I investigated the postnatal characteristics of a Cre-loxP recombinant mouse that had …
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Molekulare Mechanismen der Regulation der Glukagon-Gentranskription durch die Pax6-Homöodomäne
… Niveau reguliert, wobei der Transkriptionsfaktor Pax6 eine essentielle Rolle spielt. Pax6 bindet in vitro über seine Paired-Domäne an das PISCES-Motiv im G1- und G3-Element des Glukagon-Genpromotors und aktiviert synergistisch die Transkription des Glukagon-Gens. Pax6 besitzt noch eine weitere …
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Regulation of polycomb repressive complexes at the neural differentiation gene Pax6
… compaction at the neural differentiation gene Pax6 is maintained by FGF signalling in the stem zone/caudal lateral epiblast of the mouse embryo (Patel et al., 2013). Here I show that this process is mediated by ERK signalling, with just one hour of ERK inhibition leading to a decompaction of …
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Regulation of Notch Ligands Dll1 and Jag1 by Pax6 during cortical development
… effects. The paired-box transcription factor Pax6 has been identified as a master regulator of gene networks involved in cortical development and its deletion results in numerous cortical defects such as an abnormally thin cortical plate and a vastly expanded proliferative zone. Previous work …
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Complex Regulation of Pax6 Neuronal Progenitors By Rb Family Members During Corticogenesis
… exists between Rb family members and Pax6 progenitors during corticogenesis, underscoring the intricate nature of the network connecting the Rb and E2f families in vivo.
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Spatial and temporal regulation of cerebral cortex development by the transcription factor pax6
… dorsal telencephalon. The transcription factor Pax6 is expressed in apical progenitors (APs) throughout corticogenesis in a rostro-lateralhigh to caudo-mediallow gradient. The current studies focus on elucidating the spatial and temporal role of Pax6 in cortical development. I first analysed the …
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Probing PAX6-DNA interactions using high-throughput yeast one-hybrid assays and deep mutational scanning
PAX6 is a highly conserved transcription factor essential for the correct development of the central nervous system, the pancreas, and the eye. Heterozygous deletions, nonsense, and frameshift mutations are generally well characterised as causing aniridia, while most missense variants produce a …
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Charakterisierung eines neuen Proteins, Mapl-1 und seine Rolle in der Regulation der Pax-6 Funktion.
… Kaskaden einnehmen. Die Funktion von Pax6 ist sowohl bei Vertebraten als auch bei Invertebraten mit der Entwicklung des visuellen Systems eng verknüpft. Das Verständnis der Wikung des Pax6 Proteins während der Embryogenese erfordert die Aufklärung der molekularen Aspekte seiner …
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Strukturelle und funktionelle Untersuchung der Promotorregionen der menschlichen PAX3-, PAX6- und PAX7-Gene: Bedeutung von Polymorphismen für schizophrene Erkrankungen
… die Promotorregionen der menschlichen PAX3-, PAX6- und PAX7-Gene charakterisiert. Weiterhin wurden funktionelle Folgen der mit diesen Promotoren assoziierten Repeat-Polymorphismen auf die Expression dieser Gene untersucht. Schliesslich wurde die Relevanz für die psychischen Erkrankungen wie …
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Removal of Pax6 from cortical progenitors renders them abnormally likely to switch fate in response to Sonic Hedgehog activity
The paired-box protein PAX6 is a transcription factor that acts as a master regulator during neurodevelopment. In mice, it is expressed by neural progenitors in the cortical ventricular zone (VZ) where it regulates neurogenesis and fate specification. The complex processes of neurodevelopment are …
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Direct generation of region-specific induced neural Precursors from adult human fibroblasts using non-viral and viral methods
… defined neural transcriptional factors SOX2 and PAX6. However, the understanding of the underlying gene changes that occur during reprogramming was limited, as gene characterisation in direct reprogramming of induced neural precursors (iNPs) often relies on the expression profile at the endpoint …
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A Role for Glycogen Synthase Kinase 3 beta in the Regulation of Glucagon Gene Transcription by Insulin
… Wirkung von GSK3 über den Transkriptionsfaktor Pax6. Die transkriptionsaktivierende Wirkung von Pax6 und CBP wurde durch den GSK3 Inhibitor SB-216763 aufgehoben. Dies wurde in einem GAL4-System gezeigt. Rekombinantes GSK3b phosphorilierte die Transaktivierungsdomäne von Pax6 und ein …
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GENETIC CONTROL OF EYE AND CENTRAL NERVOUS SYSTEM DEVELOPMENT
… by haploinsufficiency of transcription factor PAX6, is characterized by complete or partial iris hypoplasia with associated foveal hypoplasia. Brain imaging performed in patients heterozygous for PAX6 mutations often reveal absence of the brain anterior or posterior commissure, absence of the …
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Identifizierung und Charakterisierung von Genen für die Entwicklung des cerebralen Cortex
… und für die Transkriptionsfaktoren Ets-1 und Pax6 identifiziert. In der vorliegenden Arbeit wurde eine verringerte Expression von PIPPin in der homozygoten Pax6-Mutante "Sey" beobachtet. Weiterführende Deletionsanalysen des PIPPin-Enhancers werden zeigen, inwiefern ein direkter Zusammenhang …
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