Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"PAX5"”.
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Pax5 Haploinsufficiency Cooperates with BCR-ABL1 to Induce Acute Lymphoblastic Leukemia
… in 40% of B-progenitor ALL cases. The <em>PAX5</em> gene was the most frequent target of somatic mutation, being altered in 31.7% of cases. The identified <em>PAX5</em> mutations resulted in reduced levels of PAX5 protein or the generation of hypomorphic alleles. Deletions were also …
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Mise en évidence et caractérisation de l'intéraction entre PAX5 et PARP-1
… étudier si une telle intéraction existe entre Pax5 et PARP-1, étant donné la similarité structurale entre Pax5 et Pax8. Une fois cette interaction établie, on sera en mesure de caractériser cette dernière et de déterminer son implication dans un contexte oncogénique".--feuille v.
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Differential Pax5 Levels Promote Mcl Dispersal and Progression and Predict A Poor Prognosis In Advanced Mcl Patients
<p>Although PAX5 conditional silencing in mice models led to aggressive lymphoma formation, there has been a lack of understanding in the precise functions of PAX5 in human B cell cancers. PAX5 expression is used to diagnose different B cell lymphoma in the clinic including mantle cell lymphoma …
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Épissage alternatif et mutations ponctuelles de Pax5 chez la leucémie lymphoîde chronique et les lymphomes de cellules B
The transcription factor Pax5, or B-cell Specific Activator Protein (BSAP), possesses oncogenic properties and its expression is often deregulated in certain cases of B-cell malignancies such as non-Hodgkin lymphoma and acute lyrnphoblastic leukemia. Recent studies have revealed that the Pax5 …
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Effets moléculaires de l'estrogène et du tamoxifène dans le cancer du sein:: implication de PAX-5
"Nous avons démontré une expression anormale de Pax5 chez les lignées cellulaires mammaires cancéreuses. Cette expression est modulée par les analogues de l'estrogène y compris chez les lignées décrites comme hormono-indépendantes par l'entremise de mécanismes classiques et non-classiques …
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ELUCIDATING REGULATORY NETWORKS PROMOTING B-CELL DEVELOPMENT
… a feed-forward loop, leading to activation of PAX5, B-cell commitment and the progression to the CD19+ pro-B cell stage.
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Comparación de perfiles de metilación de genes supresores tumorales en distintos subgrupos de tumores vesicales no músculo-invasivos
… con el tiempo libre de enfermedad para PAX5 (p=0.016), WT1 (p=0.036) y BRCA1 (p=0.023) en TaBG, para VHL (p=0.034), PAX6 (p=0.043), ATM (p=0.009), CHFR (p=0.049) y RB1 (p=0.013) para T1BG y para PYCARD (p=0.027) en T1AG. En el análisis multivariado, se obtuvieron como factores …
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Characterization of Loop Extrusion and Regulatory Elements in IgH Locus Structure and Function
… a series of distal VH enhancers, EVH1-4 and the Pax5-activated intergenic repeat 4 and 6 (PAIR4/PAIR6) have been identified in the Igh locus by HiC. EVH1 has been demonstrated to modulate Igh locus structure and VH gene usage during Igh rearrangement, linking Igh locus architecture with function …
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Mutational Landscape of Noncoding Ultraconserved Elements in Human Cancers: Functional Relevance and Clinical Utility
… such as the B-cell lineage specific activator PAX5. These results provide the first supporting evidence that some ncUCEs play important regulatory roles through diverse mechanisms and that analyzing their mutational status in cancer may suggest new biomarkers and therapeutic strategies</p>
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Functions of Novel Ligand-independent Flt3 Alleles and RANKL in Promoting Dissemination of Murine B-Cell Leukemias to the Central Nervous System
… commitment, since Flt3 is normally repressed by PAX5 upon B-cell commitment, co-incident with Cd19 expression. In support of this idea, we report evidence of Flt3 amplification in a rare subset of CD19- progenitors, and we show that CD19- FLT3+ cells from leukemic TM mice contain …
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Genomics, Diagnosis, Novel Targeted Therapies and Characterisation of the Drivers of Relapse in Philadelphia Chromosome-Like Acute Lymphoblastic Leukaemia
… synergy against the commonest JAK fusion, PAX5::JAK2. This synergy may be due to inhibition of STAT3/5 or oxidative phosphorylation, or both. Ongoing clinical trials of novel JAK/STAT inhibitors are at risk of compromise due to the emergence of resistance. The ETV6::JAK2 p.G993A in vitro …
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Spatial organisation of the immunoglobulin heavy chain locus and inter-chromosomal gene networks driving B cell development
… and maintenance of B cell identity, including Pax5, Foxo1, Ebf1, and Runx1. I have validated these by 3D DNA FISH and found that at the pro-B cell stage the Igh is involved in many trans interactions, whereas Igk does not make any contacts. In contrast, Igk gains numerous trans interactions at …