Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"PAX2"”.
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Downregulation of Pax2 Suppresses Ovarian Cancer Cell Growth
<p><em>PAX2</em> is one of nine <em>PAX</em> genes regulating tissue development and cellular differentiation in embryos. <em>PAX2</em> promotes cell proliferation, oncogenic transformation, cell-lineage specification, migration, and survival. Unattenuated <em>PAX2</em> has been found in several …
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Predicting Prognosis and Tamoxifen Response in Breast Cancer. With a special focus on contralateral breast cancer.
… AIB1 is modified by paired box 2 gene product (PAX2). PAX2 is a transcription factor important during embryogenesis, and may also play a role in carcinogenesis. This is the first time PAX2 has been investigated in well-defined cohorts of patients receiving or not receiving tamoxifen. PAX2 was …
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Genetic Control of Eye Development, a Case Study Focused on the Murine Mutation Belly Spot and Tail (BST)
… developmental period (E9-13): the boundary gene Pax2, which plays a role during optic stalk fissure fusion, and the proneural gene Hes1, which has been shown to regulate retinal ganglion cell differentiation. We cross-mated hemizygous Bst/+ mutant mice with hemizygous Krd/+ (kidney and retinal …
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Cochlear Sensitization to Aminoglycosides: Defining the Role of JAK-STAT Signaling
… genetically, Jak2 was conditionally deleted in Pax2-lineage otic tissues. Pax2-Cre;Jak2fl/fl mice showed little baseline auditory impairment, but they were markedly more susceptible to chronic kanamycin exposure. Following injury, these mice developed exaggerated auditory threshold shifts, …
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GENETIC CONTROL OF EYE AND CENTRAL NERVOUS SYSTEM DEVELOPMENT
… by haploinsufficiency of transcription factor PAX2. In the first part of this thesis we investigated the role of these Pax genes in neural development, by generating an allelic series of knock-in models at the Pax6 locus. We showed that Pax6(5a) and Pax2 could not replace Pax6 for its …
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Markers immunoistochimici delle cellule staminali/progenitrici nel rene umano in via di sviluppo.
… CD15+, vimentin+, Wt1+, CD10+, Bcl2+, Wnt1+ and PAX2+; interstitial progenitor cells were Vimentin+, Wt1+ and α1Anti-tripsin +. Our data evidence the existence of multiple stem/progenitor cell pools in the fetal and neonatal human kidney. Progenitors of these different pools are characterized by …
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The Developmental and Genetic Basis of Differences in Cave and Surface-dwelling Forms of the Crustacean, Asellus aquaticus
… the candidate genes<em> hedgehog, sine oculis, pax2, pygopus, and retinal dehydrogenase 11</em>. The results from this work have helped address evolutionary questions that have been historically difficult to dissect and have generated a much-needed animal model system to better understand when …
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The Role of PTF1A in Spinal Cord Development
… identified by homeodomain factors Lhx1/5 and Pax2. Furthermore, in the absence of PTF1a, the dI4 dorsal interneurons trans-fate to dI5 (Lmx1b+), and the dILA to dILB (Lmx1b+;Tlx3+). This mis-specification of neurons results in a complete loss of inhibitory GABAergic neurons and an increase in …
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Investigating the Transcriptional Regulation of PTF1A and the Function of PRDM13 to Specify Dorsal Spinal Interneurons
… be attributed at least in part to loss of BHLHB5;PAX2+ inhibitory neurons, known to play a role in itch. The absence of altered sensitivities in other somatosensory modalities whose information is known to be modulated in dorsal spinal cord circuits suggests itch circuitry is more dependent on …
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Engineering Complex Kidney Structures for Disease Modelling, Drug Testing, and Studying Kidney Development
… derived from a patient with heterozygous <i>PAX2</i> mutation affected by focal segmental glomerulosclerosis, we speculated that such developmental disorder might have contributed to the patient’s condition. <br></br><br></br> Overall, these findings document that our innovative and robust …
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Prdm13, a Direct Downstream Target of Ptf1a, Regulates the Balance of Gabaergic Neurons versus Glutamatergic Neurons in the Dorsal Spinal Cord
… of Tlx3. Prdm13 is also sufficient to induce Pax2 and the GABAergic phenotype. This aspect of Prdm13 function is likely indirect through repression of Tlx1/3 since it is known that Tlx1/3 normally blocks the HD factor Lbx1 that is also involved in GABAergic neuronal specification. Taken …
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Untersuchungen der Funktion des Kleinhirns mit Hilfe von Mausmutanten
… des frühen, unreifen Differenzierungsmarkers PAX2. Die dendritische Morphologie von Korb- und Sternzellen war während aller Entwicklungsphasen normal. Bezüglich der Axo- und Synaptogenese gab es aber große Unterschiede zwischen Korb- und Sternzellen. Während die Verteilung funktionaler, …