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Showing 1 to 2 of 2 for “"PAT complex"”.

  1. Mechanisms of multipass membrane protein biogenesis

    Chitwood, PatrickUniversity of Cambridge2020

    … GPCRs requires the conserved ER membrane protein complex (EMC). This is supported by biochemical reconstitution of β1-adrenergic receptor (β1AR) insertion in-vitro, which placed EMC at an early step during co-translational insertion of the first TMD (TMD1). In the absence of EMC, TMD1 was …

    cambridge Repository record

  2. Biogenesis of Multipass Membrane Proteins

    Smalinskaite, LukaUniversity of Cambridge2024

    … relies, at least in part, on the ER membrane complex (EMC), a TMD insertase recently appreciated to be a member of the universally conserved Oxa1 family of insertases. Strict dependence on Sec61 was only seen for TMD pairs separated by a translocated region longer than ≈100 amino acids. …

    cambridge Repository record