Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"PASK"”.
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Identification of Substrates and Pathways Regulated by PAS Kinase
… focused on unveiling physiological PAS kinase (PASK) substrates and interacting gene products to establish pathways regulated by PASK. First, we examined the function of PASK in the budding yeast, S. cerevisiae. An unbiased biochemical screen for putative PASK substrates from cellular extracts …
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The development of a molecular chaperone-based system to improve the heterologous production of Plasmodium falciparum AdoMetDC protein in E. coli.
… pMRBAD/PfHsp70-1 (encoding PfHsp70-1) and either pASK-IBA/PfAdoMetDC (encoding PfAdoMetDC, either as wild type or codon harmonized version) or pASK-IBA/PfAdoMetDC/ODC (encoding PfAdoMetDC/ODC, either as wild type or codon harmonized version), followed by induction to facilitate the production of …
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Science as a growing system: A cybernetic essay
… adaptative learning process (in the sense of G. PASK and H. VON FOESTER). The use of this approach allows, in particular: - to demonstrate that Science may be globally regarded as a (time-"space") growing system; - to give expression to this growth in terms, of an evolutionary model binding the …
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Permanent running repairs: The successful failure of statutory homelessness policy in London
England has a statutory definition of homelessness, and prescribed levels of provision for homeless households. Policy is set by central but delivered by local government. 66% of the national demand for homelessness services is concentrated within London, where service provision is fragmented …
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Facilitating Healthy Interpersonal Relationships for Adolescents with Autism: An Examination of Knowledge Acquisition and Retention Over Time
The study seeks to evaluate the effectiveness of the Healthy Relationships & Autism (HR) curriculum (Sutton & Wesley Spectrum Services, 2013), which is a developmentally sequenced, manualized treatment intended for children and adolescents with an Autism Spectrum Disorder (ASD). The HR curriculum …
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The role of error factors in teaching
… into 'learning set' formation. Lewis and Pask subsequently incorporated Harlow's ideas in their own work, 'and laid particular stress on the significance of error factors which give rise to whole classes of errors. The concept of error factors and the role of error factors in teaching, is …
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An examination and confirmation of a macro theory of conversations through a realization of the protologic Lp by microscopic simulation
… of conflict. Conversation Theory as developed by Pask led to the protologic called Lp which describes the interaction of conceptual entities. Lp contains injunctions as to how entities can and may interact, including how they may conflict and how their conflict may be resolved. Unlike existing …
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Relating Thompson's group V to graphs of groups and Hecke algebras
… tree, by tree automorphisms. Brownlowe, Mundey, Pask, Spielberg and Thomas constructed a $C^*$-algebra for a graph of groups, writtten $C^*(\mathcal{G})$, which bears many similarities to the $C^*$-algebra of a directed graph $G$. Inspired by the fact that directed graph $C^*$-algebras $C^*(G)$ …
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Structural Basis of Signal Transduction within Environmental Sensing PAS Regulated Ser/Thr Kinases
… how the PAS domains of a human <strong>(hPASK)</strong> and plant phototropin <strong>(<em>Avena sativa</em> phototropin 1, AsPhot1)</strong> control effector STK function. Both proteins contain tandem sensory PAS domains (<strong>PAS-A & PAS-B in hPASK; LOV1 and LOV2 in AsPhot1</strong>) …
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Protein factors and 5' flanking sequences involved in the expression of the mouse myelin basic protein gene.
… 2i, the E2F family transcription factor, the PASK protein and two of the clones were identified as c-jun. One clone, however, remains unidentified and this could be a novel transcription factor.
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Rutas de transducción de señales y procesos de fosforilización implicados en la regulación de canales erg por TRH
… que el bloqueo de la expresión de la quinasa PASK no produce un efecto apreciable en la modulación de erg por la TRH en ninguno de los dos tipos celulares. Por último, hemos demostrado que las quinasas ERK1/2 son necesarias para la correcta transmisión de la señal de la TRH en células GH3, …
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Autoinhibition and Chloride Sensing in the WNK1 Kinase
… retains a conserved RFXV binding site from the PASK/FRAY homology 2 (PF2) domain present in OSR/SPAK. Titration data shows that incubation with a 5-mer and a 20-mer peptide derived from the WNK1 kinase domain displays extensive chemical shift perturbation as assessed by 1H,15N-HSQC. Expression …
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Investigating the polyphosphate interactome with lysine- and histidine-rich proteins
Inorganic polyphosphate (polyP) is a biomolecule whose diverse functionality greatly belies its simple structure. PolyP is comprised of repeated inorganic phosphate units forming high energy phosphoanhydride linked polymers. Numerous studies have highlighted its vast portfolio of functions that …
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Targeting chromosomal instability: screening and characterization of CIN killers.
Chromosomal INstability (CIN), a hallmark of cancer cells, refers to a state in which cells have an increased rate of gain or loss of whole chromosomes or large chromosomal fractions. CIN is linked to the progression of tumours with poor clinical outcomes such as drug resistance and metastasis. …