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Showing 1 to 20 of 31 for “"PARP1"”.

  1. Tumor suppressive effect of PARP1-FOXO3 pathway

    조, 유나2015

    … 도움이 될 수 있다. 그 중 Poly (ADP-ribose) polymerase1 (PARP1) 은 많은 암 종류에서 항암치료의 타겟으로 보고되어 왔으며 PARP1억제제를 이용한 임상시험이 다양한 암 종을 바탕으로 진행되었으며 현재까지 수행되고 있다. 하지만, PARP1을 저해하게 되면 종양 발달이 어떻게 억제가 되는지 충분히 설명되어지지 않고 있다. 따라서, 위암 세포를 이용하여 PARP1 저해제인 올라파립 (Olaparib) 뿐만 아니라 PARP1 siRNA를 가지고 PARP1의 저해가 암세포의 성장을 어떻게 조절하는지를 …

    ajou Repository record

  2. DNA repair proteins Metnase and PARP1 regulate DNA integration

    Nie, Jingyi, author, Nickoloff, Jac A., advisor, Bailey, Susan M., committee member, Liber, Howard L., committee member, Chen, Chaoping, committee memberColorado State University. Libraries2015

    … Initiation of aNHEJ requires end resection. PARP1 plays an important role in initiating aNHEJ by recruiting end resection factors to DSBs. PARP1 has also been shown to promote DSB-induced chromosomal translocations. Based on the structural similarity between chromosomal translocations and DNA …

    colostate Repository record

  3. Analysis of Interrelationships Among NAD+, PARP1, ADP-Ribosylation, and Splicing in Murine Embryonic Stem Cells

    Jones, Aarin2024

    … have implicated poly(ADP-ribose) polymerase 1 (PARP1), an abundant nuclear enzyme that plays key roles in a variety of nuclear processes, in ESC self-renewal and lineage commitment. Given the diverse molecular functions of PARP1, I sought to determine the potential regulatory role of PARP1 in …

    utswmed Repository record

  4. PARP1 and immune checkpoint inhibition after chemotherapy induction in leiomyosarcoma: a model to unleash immunoresponse

    Valabrega, Giorgio, Merlini, AlessandraUniversità degli Studi di Torino2022

    unito Repository record

  5. Study of the Gain-of-Function Mutant p53 and PARP1 in Triple-Negative Breast Cancer

    Lundine, DevonThe Graduate School and University Center of The City University of New York2021

    … replication factors including PCNA, MCM2-7, and PARP1 (termed the mtp53-PARP-MCM axis). In this thesis, we explore the contribution of mutant p53 and PARP1 in castration-resistant prostate cancer (mutant p53 P223L and V274F) and triple-negative breast cancer (mutant p53 R273H). In the …

    cuny-grad Repository record

  6. Development of Rational Combination Therapy With Parp Inhibitors and Kinase Inhibitors In Tnbc

    Yu, Wen-Hsuan2017

    … c-Met, a tyrosine kinase, phosphorylates PARP1 at Y907 and that the phosphorylation increases PARP1 activity, thereby rendering cancer cells resistant to PARPi. The combination of c-Met inhibitors (METi) and PARPi has a synergistic effect for c-Met overexpressed TNBC <em>in vitro</em> and …

    uthsc Repository record

  7. Function and regulation of PARP13 binding to cellular RNA

    Todorova, Tanya (Tanya Todorova)Massachusetts Institute of Technology2015

    Poly(ADP-ribose) polymerase-13 (PARP13) is a member of the PARP family of proteins - enzymes that use NAD+ to synthesize a posttranslational protein modification called poly(ADP-ribose) (PAR). PARPs function in multiple cellular pathways, and recently several members of the family have been …

    mit Repository record

  8. Developing 1,2,3,4-tetrahydro-5H-aryl[1,4]diazepin-5-ones and Related Scaffolds as Poly-(ADP-ribosyl) Polymerase (PARP) Inhibitors and Exploring Their Targeted Polypharmacology with Kinases

    Sulier, Kiaya Minh-LiVirginia Tech2017

    … of cyclin-dependent kinase 1 (CDK1) and PARP1 is known. Evaluation of PARP1 and CDK1 pharmacophores led to the development of the tetrahydro-arylazepinone (TAAP) scaffold as a potential dual PARP1/CDK1 inhibitor. We screened a handful of TAAP analogs against PARP1 in a cell-free assay …

    vt Repository record

  9. Investigating the Role of PARylation in Regulating Skeletal Muscle Mass and Function in Healthy Mature Mice

    Pandey, DheerajUniversité d'Ottawa / University of Ottawa2023

    … the role of poly(ADP-ribose) polymerase 1 (PARP1) and PARG in the skeletal muscle of healthy mature mice under normal physiological conditions. Specifically, we validate the deletion of Parp1 and Parg in inducible skeletal muscle-specific KO mouse models followed by performing general …

    ottawa-retro Repository record

  10. Farnesylation-dependent regulation of transcripts by PARP13

    Uchima, LilenMassachusetts Institute of Technology2015

    PARP1 3 is a RNA-binding and catalytically inactive member of the poly(ADPribose) (PARP) family. PARP13 was first identified as a host antiviral factor that selectively binds to viral mRNAs and targets them for degradation by mRNA decay factors. Recently, functions of PARP13 in post-transcriptional …

    mit Repository record

  11. Functional characterization of poly(ADP-ribose) dependent ubiquitin E3 ligase in the DNA damage response

    김, 재진2016

    … response signaling 10 1. DNA damage induced PARP1 activation 10 2. Free pADPr polymer function in DNA damage response 11 E. Aim of this study 12 Ⅱ. MATERIAL AND METHODS 13 1. Cell lines 13 2. Plasmids and antibodies 13 3. Laser micro-irradiation 16 4. HR and NHEJ analysis 17 5. Neutral comet …

    ajou Repository record

  12. Novel functions of N-acetyltransferase 10 (NAT10) in DNA repair and replication with potential implications for premature ageing syndromes

    Lam, JonathanUniversity of Cambridge2021

    … DSBs, dependent on the activity of the protein PARP1, and promotes repair by one of the main DSB repair pathways, homologous recombination, most probably by allowing the initial MRE11-mediated resection step to occur. Supporting this repair-promoting role, I also showed that depleting NAT10 …

    cambridge Repository record

  13. Characterization and therapeutic evaluation of a traumatic brain injury model in compliance with common data elements

    Allende labastida, JavierThe University of Texas Medical Branch at Galveston2022

    … (Lynparza®) is a Poly(ADP-polymerase) 1 (PARP1) inhibitor approved by the FDA for the treatment of breast and ovarian cancer. Several studies reported the activation of PARP1 after injury in the central nervous system. This activation has been correlated with increased inflammation, …

    utmb Repository record

  14. A functional role of chromatin remodeling factor, Rsf-1 in the DNA damage signaling pathway

    조, 수진2014

    … sites (DSBs) in poly(ADP-ribosyl) polymerase 1 (PARP1)-dependent manner in DNA damage response (DDR), the function of Rsf-1 is still elusive. Here we show that Rsf-1 is recruited to DSBs confirmed by various cellular analyses (immunofluorescent microscope, micro-irradiation and stably integrated …

    ajou Repository record

  15. Combinatorial Modulation of Multiple Signaling Pathways to Gain Therapeutic Response in Breast and Prostate Cell Carcinomas

    Hawkins, William Tressel, II2014

    … was shown to involve prolonged activation of PARP1 which could be suppressed by inhibition of ERBB1, MEKl , PI3 kinase or PARP1. Therefore, the combination of hCG, lovastatin and radiation may represent a novel approach to kill prostate cancer cells and potential new therapy.

    vcu Repository record

  16. NQO1-Bioactivatable Drugs at the Interface of Cancer Metabolism and the DNA Damage Response

    Chakrabarti, Gaurab2017

    … strand breaks and poly(ADP-ribose) polymerase 1 (PARP1)-driven depletion of intracellular NAD+. However, tumor cell NADPH and glutathione (GSH) biogenesis can attenuate the efficacy of this class of drugs by blunting the ROS formation produced from the futile redox cycle. Therefore, it is …

    utswmed Repository record

  17. Cdk12 regulates DNA repair Genes by suppressing intronic polyadenylation

    Dubbury, Sara JaneMassachusetts Institute of Technology2018

    … that cause replication fork collapse, such as Parp1 inhibitors. The proposed role for Cdk12 in regulating HR is clinically significant for two reasons. First, Cdk12 loss-of-function mutations populate high-grade serous ovarian carcinoma and castration-resistant prostate tumors raising the …

    mit Repository record

  18. Investigating the effect of conventional chemotherapies, Cisplatin and Doxorubicin, in combination with a nuclear transport inhibitor, INI-43, on cerfical cancer cells

    Wilensky, GabriellaDivision of Medical Biochemistry2023

    … of apoptotic death, Caspase-3/7 activation and PARP1 cleavage, respectively, in single and combination treated cells. gH2AX was also investigated via western blot analysis to determine levels of DNA damage in single and combination treated cells. Results: Combination index values were determined …

    cape-town Repository record

  19. Folate Deficiency and Its Effect On Dna Repair

    Noxon, Virginia

    … another BER enzyme, Poly-ADP-ribose polymerase (PARP1). Moreover, the study also found an increase in sensitivity to PARP inhibition under folate deficient conditions. Taken together, the results demonstrate that BER status influences the sensitivity of cancer cells to folic acid deficiency, and …

    south-carolina Repository record

  20. Cellular functions and enzymatic activity of the poly(ADP-ribose) polymerase protein family

    Vyas, Sejal (Sejal Kamlesh)Massachusetts Institute of Technology2014

    … on sequence homology to the catalytic domain of PARP1, the founding PARP member and main generator of nuclear PAR modifications, it was thought that the remaining family members also synthesize PAR. However, bioinformatics analysis has predicted that many PARPs in fact generate only …

    mit Repository record

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