Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 159 for “"PARP"”.
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PARP-estäjät BRCA-positiivisen rintasyövän hoidossa
… Kaisla Helmi Susanna Karjaluoto Työn nimi: PARP-estäjät BRCA-positiivisen rintasyövän hoidossa Työn laji: Kandidaatintutkielma Kuukausi ja vuosi: huhtikuu 2026 Sivumäärä: 20 Avainsanat: rintasyöpä, BRCA-mutaatio, PARP, PARP-estäjät, talatsoparibi, olaparibi Ohjaaja: Yliopistolehtori Tuuli …
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Δεδομένα φαρμακοεπαγρύπνησης των PARP inhibitors στον καρκίνο ωοθηκών και μαστού / Pharmacovigilance data of PARP inhibitors in ovarian and breast cancer
… η τοξικότητα των φαρμάκων είναι αρκετά υψηλή. Οι PARP αναστολείς (Poly ADP-Ribose Polymerase inhibitors) ανήκουν σε μία οικογένεια ενζύμων που λόγω της συνθετικής θνησιμότητας που προσφέρουν χρησιμοποιούνται στην ογκολογία ως στοχευμένες αντικαρκινικές θεραπείες. Στην παρούσα διπλωματική, …
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Studies of PARP-1 activation and inhibition using NMR spectroscopy
Poly(ADP-ribose)polymerase 1 (PARP-1) is a highly abundant multi-domain chromatin-associated enzyme found in all higher eukaryotic cell nuclei. It is the founding member of the PARP family of enzymes that modify themselves and other proteins by adding negatively charged poly(ADP-ribose) chains …
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Parp Inhibitor Upregulates Pd-L1 Expression and Enhances Cancer-Associated Immunosuppression
… Inhibitors of poly (ADP-ribose) polymerase (PARP) have shown substantial cytotoxic effects against tumors with defects in DNA damage responses. However, whether a crosstalk between PARP inhibition and immune checkpoints exists remains unclear. Here, it has been shown that PARP inhibitors …
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Receptor Tyrosine Kinases-Mediated Acquired Parp Inhibitor Resistance In Breast Cancer
… Small molecule poly(ADP-ribose) polymerase (PARP) inhibitors (PARP-is) have been approved for clinical use in treating breast cancer and ovarian cancer patients bearing DDR-deficient tumors with mutations in breast cancer susceptibility genes (<em>BRCA</em><sup>m</sup>). However, accumulating …
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Poly (ADP-ribose) polymerase-1 (PARP-1) induces human trophoblast syncytialization
… Nuclear enzyme Poly ADP-ribose Polymerase-1 (PARP-1) and the transcriptional repressor Snail-1 work with ILK to downregulate epithelial cell-cell adhesion. This process would also be necessary for proper trophoblast syncytialization. Thus, it was hypothesized that PARP-1 would be an important …
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Rational identification of a dual inhibitor of PARP-1 and ATM kinase
… cells, which can be exploited by DDR inhibitors. PARP inhibitors are used to exploit the synthetic lethality between pharmacological inhibition of PARP (poly-ADP ribose polymerase) and BRCA (breast cancer gene) defects leading to successful patient treatment in ovarian, breast and prostate …
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Chemical Genetic and Genomic Discovery of PARP-1-Dependent Mechansims of Transcriptional Regulation
Poly(ADP-ribose) polymerases, or PARPs, are a family of enzymes that modulate diverse biological processes through covalent transfer of ADP-ribose from NAD+ onto target proteins. These targets of post-translational modification as well as the genomic targets, or binding sites, to which the nuclear …
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Development of Rational Combination Therapy With Parp Inhibitors and Kinase Inhibitors In Tnbc
<p>Poly (ADP-ribose) polymerase inhibitors (PARPi) emerge as potential targeting drugs for BRCA-deficient cancers including triple negative breast cancer (TNBC). However, it has been reported that a subgroup of patients even with BRCA mutation fails to respond to PARPi in multiple clinical trials. …
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Tracking Treatment Response and Resistance to Parp Inhibition (Talazoparib) In Hereditary Pancreatic Cancer.
<p>polyADP ribose polymerase (PARP) inhibitors are a class of drugs that block the PARP enzymes, involved in the repair of singe-stranded DNA breaks through the base excision repair pathway. PARP inhibition leads to replication-associated double stranded DNA breaks, which are repaired by homologous …
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Identification of Artemis and PARP-1 interacting factors: A yeast two hybrid screening approach
… survival (DNA repair) or apoptosis. Artemis and PARP-1 are two proteins with significant implications in the various branches within the DNA damage response network. A series of yeast two hybrid screening (Y2H) experiments were conducted using both classical and interacting mating Y2H systems to …
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Mise en évidence et caractérisation de l'intéraction entre PAX5 et PARP-1
… si une telle intéraction existe entre Pax5 et PARP-1, étant donné la similarité structurale entre Pax5 et Pax8. Une fois cette interaction établie, on sera en mesure de caractériser cette dernière et de déterminer son implication dans un contexte oncogénique".--feuille v.
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Nuclear translocation of Gasdermin D (GSDMD) sensitizes chemotherapy through inhibiting PARP-1 in colorectal cancer
… regulation of poly (ADP-ribose) polymerase-1 (PARP-1) mediated DNA repair. After chemotherapeutic drug treatment induces full-length GSDMD nuclear translocation, GSDMD interacts with nuclear protein PARP-1 to dramatically inhibit its DNA Damage Repair-related function, to act similarly like the …
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MODELING COHESIN-DEPENDENT ONCOGENESIS IN VITRO AND IN VIVO: POSSIBLE AMELIORATIVE EFFECTS OF PARP INHIBITION
… I also showed that Poly (ADP-ribose) polymerase (PARP) depletion or inhibition which is used to treat forms of cancer with defects in DNA repair ameliorated phenotypes of SA-deficient animals. Finally, I studied the effect of STAG2 downregulation in human in vitro models using shRNA technology in …
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Toward a Quantitative Analysis of PARP-1 and Poly(ADP-ribosyl)ation in Cellular Senescence
… have been done to explore a possible role for PARP-1 — the enzyme responsible for synthesis of 90% of cellular PAR — in mechanisms of senescence. Furthermore, many techniques currently used for analysis of protein poly(ADP-ribosyl)ation are fraught with imprecision. We therefore sought to …
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Untersuchungen zur Inhibierung der Expression der Poly(ADP-ribose)Polymerase (PARP) nach Infektion mit Toxoplasma gondii
… der Expression der Poly(ADP-Ribose) Polymerase (PARP)-1. PARP-1 ist ein nukleäres Protein und spielt eine wichtige Rolle in verschiedenen zellulären Abläufen einschließlich DNA Reparatur, Apoptose, Nekrose und Regulation der Genexpression. Außerdem ist es an der Pathogenese von verschiedenen …
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