Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"PARN"”.
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Global analysis of mRNA decay rates and RNA-binding specificity reveals novel roles for CUGBP1 and PARN deadenylase in muscle cells
… roles of CUGBP1 and its partner, the deadenylase PARN, in mRNA decay in mouse C2C12 muscle cells. The TNF message, which encodes a cytokine known to cause muscle wasting and insulin resistance when over-expressed, was stabilized by depletion of CUGBP1. The normally rapid decay of the TNF mRNA was …
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The Role of Nucleolin Phosphorylation by CK2 in Regulating Cellular Fate Under Normal and Stress Conditions
… through affecting NCL interaction with PARN deadenylase and the target gene <em>TP53 </em>mRNA, as well as with ARE-binding protein HuR to mediate HuR availability to their common target <em>TP53</em> mRNA. Dr. Kleiman’s lab determined that NCL can bind to the 3’UTR ARE of <em>TP53</em> …
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Λειτουργικές και γονιδιωματικές μελέτες επί της αποαδενυλίωσης: ο ρόλος του γονιδίου PNLDC1
… την PAN2 και την poly(A)-specific ribonuclease (PARN). Στην παρούσα διατριβή μελετήθηκε το γονίδιο PNLDC1 που βρέθηκε ότι κωδικοποιεί μια νέα DEDD αποαδενυλάση και βρίσκεται σε όλους του ανώτερους ευκαρυωτικούς οργανισμούς. Ο προαγωγέας του γονιδίου PNLDC1 βρέθηκε μεθυλιωμένος και απομεθυλίωση …
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Actin-like filament A (AlfA) and AlfA-driven plasmid segregation
… protein AlfB and the centromeric DNA sequence parN. We obtained a near-atomic resolution structure of an AlfA filament in the presence of AMP-PNP using cryo-electron microscopy (cryo-EM). We built an atomic model based on the electron density map and the sequence information to reveal the …
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Sélection de promoteurs ARN reconnus par l'ARN polymérase de Escherichia coli
… Aussi, l'analyse de la séquence des petits ARN (pARN) produits lors de la réplication révèle l'implication des 6 nt pour fixer l'initiation de la polymérisation. En conclusion, ces résultats s'ajoutent aux évidences qui mèneront vers la découverte des séquences nécessaires à la réplication d'une …
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Structural and functional characterization of proteins involved in the biogenesis of spliceosomal U snRNPs
… der Poly(A)-spezifischen Ribonuklease (PARN) wurde gereinigt und im Komplex mit dem cap-Analog m7GTP kristallisiert. Die Analyse der Kristallstruktur sowie weitere biochemische Charakterisierungen zeigten, dass das positiv geladene m7G-cap in einer bisher nicht beobachteten Form an das …
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Regulation and function of the RNA-binding protein CELF1
… inhibit CELF1s recruitment of the deadenylase PARN, thus inhibiting CELF1 mRNA decay. The inhibition of CELF1 mediated decay is expected to result in the stabilization of a network of proliferation and apoptosis regulatory transcripts, leading to dysregulation of these pathways and potentially …