Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"PARK2"”.
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Role of PARK2Gene in Maintenance of Pancreatic Beta Cell Functions
… that two SNPs, rs10455889 and rs9365294, in the PARK2 gene encoding an E3 ubiquitin-protein ligase (parkin) were significantly associated with fasting plasma glucose levels and insulin secretion indices in response to glucose stimulation in men (3,747 subjects). Replication analysis in two other …
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Investigating the effects of Wnt/β-catenin Signalling on Melanoma Cell Metabolism and Mitochondrial Dynamics
… binds to the mitochondrial regulatory protein PARK2 in melanoma cells and subsequently blocks the autophagy dependency of melanoma cells. In summary, we demonstrate that activation of Wnt/β-catenin signalling in melanoma cells can lead to reduced cellular metabolism coupled with highly altered …
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The mechanism of Parkin activation by PINK1 phosphorylation
Mutations in the E3 Ub ligase Parkin (PARK2) and the protein kinase PINK1 (PARK6) are genetically linked to Young-Onset Parkinson’s Disease. The two enzymes orchestrate clearance of damaged, cytotoxic mitochondria through a specialized form of autophagy termed mitophagy. By phosphorylating …
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Heredity in Parkinson's disease. From rare mutations to common genetic risk factors.
This study investigated genetic causes of Parkinson's disease (PD) and parkinsonism in southern Sweden. The extensive Lister Family with parkinsonism caused by duplications and triplications of the gene for alpha-synuclein (SNCA) was studied. Clinical, genetic and genealogical data were compiled …