Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"PARG"”.
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Strategies for structural studies of poly(ADP-ribose) glycohydrolase: Towards the validation of a novel therapeutic target
… enzyme poly(ADP-ribose) glycohydrolase (PARG). PARP-1, the first-discovered and major PARP, has been the focus of many studies aimed at clarifying the biological function of poly(ADP-ribose) (PAR). This abundant nuclear enzyme plays key roles in a variety of cellular processes, including …
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Chemical Tools to Monitor and Inhibit poly(ADP -Ribosyl)ation
… enzyme poly(ADP-ribose)glycohydrolase (PARG) is available, and therefore it has been difficult to intelligently design compounds to inhibit this enzyme. To date, the known inhibitors of PARG can be predominantly grouped into the three categories of DNA intercalators, tannins, and …
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Development of poly(ADP-ribose) glycohydrolase inhibitors and tetracyclic indoles as anticancer compounds
… development of poly(ADP-ribose) glycohydrolase (PARG) inhibitors as putative anticancer compounds as well as the discovery of a class of potent anticancer tetracyclic indoles through a phenotypic screen. PARG plays a crucial role in DNA damage repair, and lack of PARG activity after DNA damage …
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The discovery of small molecule inhibitors of poly(ADP-ribose) mediated cell death
… inhibitors of poly(ADP-ribose) glycohydrolase (PARG), the enzyme that degrades PAR, and apoptosis inducing factor (AIF), a protein that orchestrates stage I chromatin condensation. Recognizing that the phosphate moiety, which is cell impermeable, is necessary for PARG recognition and binding, …
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Investigating the Role of PARylation in Regulating Skeletal Muscle Mass and Function in Healthy Mature Mice
… such as poly(ADP-ribose) glycohydrolase (PARG). This thesis characterizes the role of poly(ADP-ribose) polymerase 1 (PARP1) and PARG in the skeletal muscle of healthy mature mice under normal physiological conditions. Specifically, we validate the deletion of Parp1 and Parg in inducible …
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The Modulation of Life and Death: Small Molecule Activators and Inhibitors of Necrotic and Apoptotic Pathways
… inhibition of poly(ADP-ribose) glycohydrolase (PARG). Through the development of high-throughput screens, a small molecule activator of procaspase-3 (PAC-1) and an inhibitor of PARG (PIP-1) were identified. PAC-1 was shown to potently induce apoptosis in mammalian cells in a manner directly …
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Enzymatic synthesis of defined-length poly(ADP-ribose) and the investigation of cell-permeable poly(ADP-ribose) glycohydrolase inhibitors
… cells, and Poly(ADP-ribose) Glycohydrolase (PARG) inhibition is investigated as an alternate pathway to PARP inhibition in genotoxic chemotherapy. However, little is known about the exact mode of interaction between PAR and different proteins mainly due to the fact that PARP produces …
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Chemical approaches to understanding small-molecule accumulation in bacteria and poly(ADP-ribosyl)ation
… measure the activity of the major PAR degraders (PARG and ARH3). Towards filling this need, novel fluorogenic substrates of PARG and ARH3 were designed and synthesized. Using these tools, the first continuous enzyme activity assays for PARG and ARH3 were developed for use with purified enzymes and …
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The chemical and enzymatic synthesis of poly(ADP-ribose)
Poly(ADP-ribose) synthesis and degradation are important cellular processes associated with the DNA damage response and many other pathways. Traditionally, these processes have been challenging to study due to the heterogeneity associated with the synthesis of poly(ADP-ribose). Discussed here are …