NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 5 of 5 for “"PAR-CLIP"”.

  1. Characterizing Human Transfer RNAs by Hydro-tRNAseq and PAR-CLIP

    Gogakos, Tasos

    <p>The participation of tRNAs in fundamental aspects of biology and disease necessitates an accurate, experimentally confirmed annotation of tRNA genes, and curation of precursor and mature tRNA sequences. This has been challenging, mainly because RNA secondary structure and nucleotide …

    rockefeller Repository record

  2. EBV BART MicroRNAs Target Pro-apoptotic and Anti-Wnt Signaling Genes to Promote Cell Survival and Proliferation

    Kang, Dong2015

    … crosslinking and immunoprecipitation (PAR-CLIP) in the EBV+ NPC cell line C666. Next, I thoroughly demonstrated that the 10 candidate target genes were substantially suppressed by expression of the relevant miR-BARTs, as measured by 3’UTR-containing firefly luciferase (FLuc) expression, …

    duke Repository record

  3. RNA Localization and Translational Regulation on the Endoplasmic Reticulum

    Hsu, Chun-Chieh2016

    … on ER-bound ribosomes (signal recognition particle pathway), or a poorly understood direct ER anchoring mechanism. In this study, we identify that the ER integral membrane proteins function as RNA-binding proteins and play important roles in the direct mRNA anchoring to the ER. We report …

    duke Repository record

  4. SR proteins in microRNA/mRNA biogenesis

    Wu, Han2011

    … the 40 differentially expressed miRNAs, miR-7 is particularly interesting, because it is also predicted to target SF2/ASF, which forms a negative feedback regulation. This is indeed the case as shown by luciferase reporter assay and overexpression/knocking down of miR-7 in vivo. To our knowledge, …

    duke Repository record

  5. Principles of HuR-RNA targeting, interaction dynamics, and functional outcomes

    Mukherjee, Neelanjan2010

    … 3 RRM (RNA-recognition motif) domains the last separated by a hinge region. It predominant role is to positively regulate the stability and translation of target mRNAs through binding to ARE (AU-rich elements) in the 3' UTR (untranslated region) of protein coding transcripts. In response to …

    duke Repository record