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Showing 1 to 8 of 8 for “"PAPP-A"”.
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The molecular characterisation of pregnancy-associated plasma protein-A (PAPP-A).
PAPP-A is a large glycoprotein with alpha2-electrophoretic mobility that is produced by the placenta during pregnancy. In this thesis a biochemical and molecular characterisation of PAPP-A was performed. The polyclonal antiserum (DAKO) directed against PAPP-A has been shown to also interact with …
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The functions of pregnancy-associated plasma protein A in rheumatoid arthritis.
Pregnancy associated plasma protein A (PAPP-A) is produced in increasing amounts with advancing pregnancy, a major source being the placenta. It was originally described as a homotetramer with ~ 200,000 M[r] subunits. An alternative structure has since been proposed of a disulphide bridged complex …
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THE METABOLIC EFFECTS OF DIET-INDUCED OBESITY AND GROWTH HORMONE TREATMENT IN LONG-LIVED MICE WITH ALTERED INSULIN AND INSULIN-LIKE GROWTH FACTOR -1 SIGNALING
… the pregnancy associated plasma protein-A (PAPPA). In vitro, PAPPA is regulated by pro-inflammatory cytokines (PICs) such as interleukin (IL)-6 and tumor necrosis factor -a (TNF-a). Mice born with deficiency of the Papp-a gene [PAPP-A knockout (KO) mice] live ∼30–40 % longer than their …
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Biomarkers of disease : concentrations in the serum of women during natural and stimulated ovarian cycles and during early pregnancy
… and pregnancy associated plasma protein‐a (PAPP‐A). The patterns of change during natural and stimulated ovarian cycles and early pregnancy were investigated to determine if these biomarkers could reflect normal events relating to ovulation and implantation/placentation. In addition, the …
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Estudio multidisciplinar de potenciales marcadores precoces de preeclampsia: estudio en muestras de sangre obtenidas en el primer trimestre de gestantes sanas y con preeclampsia
… maternos clásicos (PlGF, sFlt-1, ?-hCG y PAPP-A) y novedosos (ADNlc y MPc), medidos durante el primer trimestre, permiten predecir el desarrollo posterior de preeclampsia (PE) y sus complicaciones graves. Metodología: Se realizó un estudio retrospectivo de casos y controles que incluyó …
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Nuevos marcadores en el diagnóstico y pronóstico de la preeclampsia precoz y tardía
… y proteína plasmática A asociada al embarazo (PAPP-A) en el cribado de la enfermedad durante el primer trimestre de gestación. Finalmente, se ha estudiado la existencia de una posible relación entre la PE y la deficiencia de vitamina D determinada en diferentes momentos del embarazo. Se llevó a …
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Clinical utility of 3D power doppler ultrasound and maternal biomarkers in the prediction of pre-eclampsia in high-risk pregnancies
… (Pregnancy Associated Plasma Protein-A (PAPP-A), Placental like Growth Factor (PlGF), soluble Fms-like tyrosine kinase (sFLt-1) and soluble Endoglin (sEng)) measured in the first and second trimesters of pregnancy to predict pre-eclampsia in high-risk women.<br/><br/>To determine the …
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Localización inmunohistoquímica de las proteínas onco-placentarias en las neoplasias del Aparato reproductor.
… asociadas a la gestación, e incluye a la PAPP-A (pregnancy associated plasma protein-A), a la PAPP-B (pregnancy associated plasma protein-B), a la B1 –PAM (pregnancy associated B1 macroglobulin) y a la α2 –PAM (pregnancy associated α2 macroglobulin). 2.- Proteínas solubles de la placenta …