Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"PANX1"”.
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Biochemical and Functional Analyses of PANX1 Variants
Pannexin 1 (PANX1) is a glycoprotein capable of forming large-pore single-membrane channels permeable to signaling molecules such as ATP. In this study, we interrogated different domains by introducing naturally occurring variants reported in melanoma and assessed their impact on the channel …
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Cardiovascular Characterization of Cx40/Panx1 Single and Double Knockout Mice
… To investigate this possibility we crossed Panx1 null mice with Cx40 knockout mice and characterized the first global connexin/pannexin double knockout mouse. Intriguingly, the combined ablation of both Cx40 and Panx1 caused decreased prenatal and newborn survival, but did not affect the …
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Defining the Role of Pannexin1 in Skeletal Muscle and Satellite Cell Function in vivo and ex vivo Using a Novel Conditional Knockout Mouse Model
It has been previously shown that pannexin 1 (Panx1) channels, well known for their role in ATP release, play a key role in myogenesis. However, its role in muscle development remains to be elucidated. Using a novel skeletal-muscle-specific Panx1 knockout (Panx1^smKO) mouse model, this thesis …
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Decoding Gating Properties of the Pannexin1 Channel: ATP Release and pH Sensitivity and the Potential Role in Health and Disease
Panx1 is implicated in disorders including epilepsy and ischemia, with roles in important physiological processes including learning, memory and sensory function. In sensory systems, ATP release and purinergic signaling is considered the most important function of Panx1. Here, the function in the …
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Mutations in a Mechanosensitive Channel Enable Intravascular Metaststic Cell Survival
… alteration that yields a truncated pannexin-1 (PANX1 1-89) plasma membrane megachannel subunit—was functionally characterized. PANX1 1-89 forms a multimeric complex with wild-type PANX1 at the plasma membrane and augments PANX1 channel activity to promote cancer cell survival soon after cells …
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Pannexin-1 modulates short-term synaptic plasticity by facilitating endocannabinoid transport
Pannexin-1 (Panx1) is a large pore ion/metabolite channel that is permeable to various molecules, ions, ATP, signaling lipids, and fluorescent dyes. To date, Panx1 has been implicated in many pathological conditions including ischemia, epilepsy, cancer, and inflammation. Ascribing a physiological …
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Characterization of the Zebrafish Panx1a Phosphorylation Profile and Interactome in the Regulation of the Channel Function and Trafficking
Pannexin-1 (Panx1) is an integral membrane protein that forms heptameric channels, involved in the communication between the intracellular and the extracellular environment. Its primary function is to passage small molecules, such as ATP, in and out of the cell, which can trigger vital cellular …
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Expression und Lokalisation von Pannexinen und Connexinen in der äußeren Retina der Maus
… Lokalisation in der äußeren Retina untersucht. Panx1-Transkripte konnten in Photorezeptoren, Horizontalzellen und Müllerzellen nachgewiesen werden. Panx2-mRNA wurde in Photorezeptoren, Horizontalzellen, Müllerzellen und Bipolarzellen gefunden. Panx2-Proteine wurden präsynaptisch in den …