Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"PANC-1"”.
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Metabolic reprogramming associated with the epithelial-mesenchymal transition in pancreatic cancer
The high rate of mortality associated with pancreatic cancer is largely attributable to its tendency for metastatic spread and resistance to chemotherapies, both of which partially underlined by the epithelial-mesenchymal transition (EMT). While the role of Warburg metabolism has been recognised in …
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The role of sphingosine-1-phosphate in the epithelial to mesenchymal transition in cancer cells
… migration in A549 lung epithelial carcinoma and PANC-1 pancreatic epithelial carcinoma cell lines. Changes in the expression of E-cadherin (an epithelial cell marker) and vimentin (amesenchymal cell marker) were difficult to detect, which compromised the aim to investigate the role for S1P. …
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Cannabinoid Type 2 Receptors Promote Cadherin Switching While Suppressing Cell Migration: A Novel Investigation into Biased GPCR Signaling
… fashion in RAW-Blue (murine macrophages) and PANC-1 (pancreatic) cells, as assessed by live-cell sialidase assay. This activity was abrogated by selective inhibitors of NMBR (BIM-23127), MMP9 (MMP9-i), and Neu1 (oseltamivir phosphate; OP), suggesting pathway specificity. Colocalization …
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Role of Methyltransferase Like-3 (Mettl3) In Pancreatic Ductal Adenocarcinoma (Pdac) Progression
<p>Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer with about a 10% five-year survival rate. The grim prognostic situation of pancreatic cancer patients underlines the need to identify novel molecular targets. Recent studies have brought to attention, the need to therapeutically …
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Nanomaterials and Block Copolymers for Overcoming Multidrug Resistance in Cancer
… to aggressive cancers such as that of the pancreas. In cancers where chemotherapy is amongst the few treatment options, it is crucial to develop chemotherapeutics that either bypass or control the development of multidrug resistance. Polymeric nanomaterials such as Pluronics® are of …
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Studies on intracellular calcium pools in a pancreatic cell line
… play important roles in Ca²⁺ signalling. In pancreatic ductal cells the precise mechanisms of intracellular Ca²⁺ movement however are not well known. The aims of the present study are to identify and characterize intracellular Ca²⁺ pools and to investigate regulation of intracellular Ca²⁺ …
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The Role of Autotaxin in Cancer
… for the treatment of patients with metastatic pancreatic cancer, in combination with gemcitabine. ENPP2 is overexpressed in both pancreatic adenocarcinoma (PDAC) and hepatocellular carcinoma (HCC). In HCC, ATX is produced by both the tumour microenvironment (TME) and tumour cells and our data …
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Developing peptide-based inhibitors of amylin aggregation as a novel treatment for type 2 diabetes
… which are considered to be cytotoxic to pancreatic -cells. Inhibiting the early stages of amylin aggregation could provide a potential therapeutic strategy for the treatment of type 2 diabetes. In this study, overlapping peptides were designed to target the binding region (RLANFLVHSS, …
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Molecular mechanisms of bioactive compounds in fruits and vegetables that inhibit pancreatic cancer and their relationship with inflammation
For all stages of pancreatic cancer, the 5-year survival rate from the time of diagnosis is 6%, with the median survival rate being only 6 months. This poor prognosis for pancreatic cancer is due to its aggressive nature and, too frequently, to its late diagnosis due to the absence of clinical …
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Multidrug resistance-associated protein 2 (MRP2) and oxaliplatin transport
… platinum were observed in HepG2 and PANC-1 cells (0.14- and 0.34-fold difference relative to HEK-P cells), which had high expression levels of ABCC2 mRNA comparable to the HEK-MRP2 cells (1360- and 139-fold difference in relative to HEK-P cells). Myricetin increased cellular platinum …
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Characterisation of RNA modifications in human cancer cells
… the enzymes that catalyse its deposition. Using pancreatic ductal adenocarcinoma cancer (PDAC) cells as a model system, I discovered that m1G methylation is present on mRNA where it is catalysed by TRMT5, an enzyme previously identified as a tRNA methyltransferase (TRMT). Utilising ribosome …
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The Phytochemistry of Selected Ancistrocladus and Monsonia Species and their Anti-Pancreatic Cancer and Nrf2 Activator Properties
… (with PC50 7.6 to 22.7 µM) towards human PANC-1 pancreatic cancer cells in nutrient-deprived medium, without showing toxicity in normal, nutrient-rich conditions. Along with the above described naphthylisoquinoline alkaloids, nine other analytes including four flavonoids: quercetin, …
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Existence of Inhibitor of Apoptosis in Tumor Exosomes
<p>Pancreatic cancer is a deadly and aggressive disease. The only option for metastatic pancreatic cancer is chemotherapy where only the antimetabolites gemcitabine (Gem) and 5-fluorouracil (5FU) are used clinically. However, resistance to these antimetabolites remains a problem highlighting the …
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Methods to Investigate Hyperthermia Induced By Tumor Treating Fields
… at 150 kHz frequency induce hyperthermia in pancreatic cancer cells. Two specific aims are set to approach this hypothesis. First specific aim is to design and develop an engineering set up capable of generating frequency with amplitude modulation to induce TTF’s (150kHz). And second aim is …
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Chemical and molecular analysis of Libyan desert plants used in camel feed
… cancer cell lines: A375 (malignant melanoma), PANC-1 (pancreatic carcinoma), A2780 (ovarian carcinoma), ZR-75-1 (breast carcinoma), LNCaP (prostate carcinoma), and HeLa (cervical cancer) and a non-cancer (PNT2) cell line using an AlamarBlue® assay. In parallel, this study also attempted to …
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Investigation of the effect of disulfiram on the chemoresistance and invasiveness in pancreatic cancer cells
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide with a mortality to incidence ratio of 94%. It is the 10th most common cancer in the UK with a 5-year survival less than 7%. In contrast to the improved therapeutic outcomes in many other cancers, the prognosis of …
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EPAC1 AS A THERAPEUTIC TARGET FOR PANCREATIC DUCTAL ADENOCARCINOMA
… of EPAC1 in promoting invasion and metastasis of pancreatic ductal adenocarcinoma (PDA) and immune regulation, through modulation of the activity of regulatory T-cells (Treg), a subset of T-cells that suppress the immune system and maintain immune tolerance. In three common PDA cell lines, AsPC-1, …
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The development and characterisation of MicroRNA and gemcitabine nanotherapies for the treatment of pancreatic cancer
Pancreatic cancer has been considered as the most lethal cancer type among adults for many decades. Especially with the failure to improve survival rates for the last 40 years, despite all the progress in targeting therapies. With the lack of therapeutic options, attention has been directed towards …
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