Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"PAMPs"”.
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Multiple Toll-Like Receptor Agonists Act as Potent Adjuvants in the Induction of Autoimmunity
… via pathogen-associated molecular patterns (PAMPs) activating Toll-like receptors (TLRs) on host cells. I investigated the role that PAMPs play in Experimental Autoimmune Encephalomyelitis (EAE), an animal model of MS. Both genetic and environmental influences contribute to the pathogenesis …
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Innate Immunity in Chickens: In Vivo Responses to Different Pathogen Associated Molecular Patterns
… known as pathogen associated molecular patterns (PAMPs) that are common to groups of microbes. Examples include LPS on Gram-negative bacteria, the structural motif PGN common to all bacteria, MDP the smallest immunostimulatory unit of PGN, and poly I:C the dsRNA analog. PAMP recognition by and …
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Modular Interactive Modeling for Control and Simulation of Electric Power Systems
… Automated Modeling of Power Systems (PAMPS) based on this recent theoretical work implements distributed algorithms in MATLAB. One example applies PAMPS to a RL (resistive and inductive) circuit controlled by a voltage source and connected to a constant power load. Future work can use …
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Ion Conducting Polyelectrolytes in Conductive Network Composites and Humidity Sensing Applications for Ionic Polymer-Metal Composite Actuators
… ly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PAMPS) and Nafion® were incorporated into an ISAM CNC film with poly(allylamine hydrochloride) (PAH) and anionic gold nanoparticles actuators to further improve bending. CNC films were optimized for bending through pH adjustments in PAH and adding …
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The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection
… distinct pathogen associated molecular patterns (PAMPs) containing 5' triphosphate and double-stranded RNA that are temporally distributed and sensed by RIG-I and MDA5 during infection. In addition to biochemical characterization of stimulatory PAMPs contained within WNV infected cells, we have …
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Molecular basis of plant cell death suppression by the phytophthora infestans effector AVR3a
… known as pathogen-associated molecular patterns (PAMPs) by cell surface receptors called pattern-recognition receptors (PPRs). Successful pathogens have evolved effectors to overcome plant defense and to colonize their host. INF1 is a P. infestans elicitin with features of PAMPs that requires the …
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Periodontal bacterial-DNA initiated immuno-inflammatory responses in human osteoblastic cells
… possess pathogen-associated molecular patterns (PAMPs) that interact with various receptors including Toll like receptors (TLRs). Bacterial DNA (bDNA) is one of the PAMPs mainly recognized by TLR9. Interaction of bDNA and its receptors leads to activation of inflammatory signaling pathways …
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Immunosuppressive Myeloid Cells in Breast Cancer and Sepsis
… pathogen-associated molecular patterns; PAMPs, or endogenous damage-associated molecular patterns; DAMPs), Wnt5a promoted the generation of immunosuppressive monocytes (CD14+HLA-DRlow/-Co-receptorlow/-). This was at the expense of generation of pro-inflammatory macrophages (M1). In …
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Hardware and software for a power-aware wireless microsensor node
… including, in particular, the design of the pAMPS processor board and its power-scalable architecture. The operating system and application programming interface for the node is described. Finally, an analysis is made of the power consumed by each of the node's subsystems, and these results …
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Regulation of macrophage subsets in homeostatic and inflammatory mucosal environments
… bacterial pathogen related molecular patterns (PAMPs), such as LPS, is well established to induce tolerisation. The aims of this project were firstly, to characterise the control of macrophage differentiation in a mucosal setting by investigating the immunomodulatory effects of PAMPs, such as …
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Regulation of DHX16-mediated Innate Immunity by Unanchored Polyubiquitin
… known as pathogen-associated molecular patterns (PAMPs). Recognition of PAMPs during viral infection requires host molecules capable of interpreting these foreign signals called pattern recognition receptors (PRRs). These PRRs trigger the production of type-I interferon (IFN-I), which is essential …
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Mechanisms of phage detection by bacterial innate immune proteins
… pathogen-associated molecular patterns (PAMPs). In addition to the MCPs, I found that CapRel_SJ46 can directly bind to another unrelated and structurally different phage protein, called Gp54. Bas11 phages harbor two trigger proteins, and both are sensed by CapRel_SJ46 during infection, …
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The role of TLR3- and MyD88-dependent signaling in the development of anti-West Nile virus adaptive immune responses induced by a vaccine candidate, RepliVAX WN.
… pathogen-associated molecular patterns (PAMPs) by host pattern recognition receptors (PRRs) results in the activation of innate signaling pathways that drive the innate immune response and ultimately shape the adaptive immune response. RepliVAX WN, a single-cycle flavivirus (SCFV) vaccine …
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MAPPIT analysis of the early events in Toll-Like receptor signalling
… pathogeen-geassocieerde moleculaire patronen of PAMPs genoemd. PAMPs zijn essentieel voor het overleven en de replicatie van deze pathogenen en zijn daarom onveranderd gebleven doorheen de evolutie. Herkenning van een pathogen door TLRs leidt tot de productie van pro-inflammatoire cytokines. Deze …
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THE MECHANISM OF JUNB TRANSCRIPTIONAL REGULATION UNDER TLR ACTIVATION IN MOUSE MACROPHAGES
… (TLR) - pathway crosstalk caused by multiple PAMPs induces proinflammatory cytokine synergy in macrophages. Several potential synergistic factors including JunB have been found. But the mechanisms of junb regulation in macrophages are unclear. In this thesis work, we showed that junb mRNA and …
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Toll-Interacting Protein Regulation of Low-grade Non-resolving Inflammation
… pathogen associated molecular pattern molecules (PAMPs) such as lipopolysaccharide (LPS). To differentiate signal strengths, innate leukocytes may utilize distinct intra-cellular signaling circuitries modulated by adaptor molecules. Toll-interacting protein (Tollip) is one of the critical adaptor …
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Dysregulation of Noncanonical NF-κB Signaling in Gastrointestinal Diseases
… of pathogen associated molecular patterns (PAMPs) to mount an immune response, as well as detecting damage associated molecular patterns (DAMP) to indicate an area of damage and signal tissue repair. The gastrointestinal tract is a major signaling hub for such immune responses, as intestinal …
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Regulation of receptor kinase-mediated immune signalling by dynamic phosphorylation
… pathogen-associated molecular patterns (PAMPs) via cell surface-localized pattern recognition receptors (PRRs), initiating a broad-spectrum defense response against pathogens, known as PRR-triggered immunity (PTI). However, immunity comes at a cost; and immune responses need to be tightly …
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Studies on the Damage Associated Molecular Patterns (DAMPs)-induced Inflammatory Events in the Brain Immune Cells
… pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). PAMPs are presented by microorganisms, whereas DAMPs include endogenous intracellular molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules that are …
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The role of PLK1 in NLRP3 inflammasome activation
… DAMPs (Damage-Associated Molecular Patterns) and PAMPs (Pathogen-Associated Molecular Patterns). Activation of the NLRP3 inflammasome leads to pro-inflammatory cytokines (IL-1 and IL-18) release and pyroptosis, an inflammasome-specific form of cell death. The kinase PLK1 plays an important and …
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