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Showing 1 to 17 of 17 for “"PAMAM dendrimer"”.
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Pamam dendrimer-based therapeutic and diagnostic nanodevices
<p>Dendrimers are ideal materials to be used in the emerging field of nanomedicine. Their nanoscale size and high density of functional groups on their peripheries allow them to be used for various biomedical applications. This work exploits dendrimers as drug delivery vehicles and a versatile …
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An Investigation of The Use of Dendrimer-Based Carrier to Cross Cellular Barrier
Dendrimers are a novel class of highly branched polymers with a high degree of uniformity and monodispersity. As a result of the unique properties and characteristics of dendrimers, they have found a wide range of pharmaceutical applications. This study investigated the ability of polyamidoamine …
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Effect of combinations of drugs on glioma chemotherapy
… of novel generation 3 (03) polyamidoamine (PAMAM) dendrimer to chemotherapeutic agent, Paclitaxel. The cytotoxicity results showed that paclitaxel, when conjugated to the 03 PAMAM dendrimer, was significantly more toxic then when used alone. P-glycoprotein (Pgp) is the major hurdle in the …
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PREPARATION AND CHARACTERIZATION OF AN ELECTROSPUN GELATIN/DENDRIMER HYBRID NANOFIBER DRESSING
… to treat chronic wounds. Comprised of gelatin, dendrimer, synthetic polymer and antibiotics, the dressing was electrospun to mimic the natural extracellular matrix (ECM). Gelatin is biocompatible, biodegradable, non-toxic, and easily available. The antibiotic, doxycycline, has the ability to …
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Design Of Functional Dendrimer Nanocarriers And Their Formulations In Propellant-Based Inhalers For Pulmonary Drug Delivery
… ratio. </p> <p>The second challenge is to design PAMAM functional dendrimer nanocarriers for the delivery of therapeutics to and through the lungs. Using molecular dynamics simulations, we investigate the microstructures of PAMAM dendrimers as a function of generation, PEGylation density, …
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Synthesis and characterization of polyamidoamine dendrons
… of this study is to synthesize Poly AMido AMine (PAMAM) dendrons using silica gel as support and characterize them. PAMAM dendron, a hyperbranch of the PAMAM dendrimer, was divergently synthesized on solid support. Prior to the propagation through (1) Michael addition of acryl ester to an amino …
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Influence on molecular geometry and chain conformation on properties of polyelectrolyte multilayers
… imine) (BPEI), or poly(amidoamine) (PAMAM) dendrimer, generation four, amine surface. Various properties of these films are compared; including film thickness, chemical functional group availability, and film composition. Carboxylic acid group ionization is found to increase with …
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Genomic and Non-Genomic Actions of Estrogen Receptor Ligands
… receptor subtype selective ligands and estrogen-dendrimer conjugates (EDCs). The activities of four novel estrogen receptor subtype selective ligands were characterized in this study. The activities of these ligands were examined at a range of promoter contexts where ER worked through a variety …
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Novel sustained release formulation of leveodopa-dendrimer conjugate
… of levodopa was prepared by conjugating it with PAMAM dendrimer which was further incorporated in a nanoparticle. To prepare the conjugate levodopa (1mg/ml) was added to dendrimer solution (1mg/ml) at alkaline pH. They were allowed to react for 45 minutes with constant stirring and then …
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Polymeric Nanocarriers And Their Oral Inhalation Formulations For The Regional Delivery Of Nucleic Acids To The Lungs
… (iii) the design of siRNA-poly(amidoamine) (PAMAM) dendrimer conjugates. We demonstrate that both DNA and siRNA can be efficiently formulated in HFA-based pMDIs upon the development of novel particle engineering strategies to overcome issues associated with their size and physical stability …
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Synthesis and Activation of Nanoscale Dendrimer-Derived Supported Noble Metal Catalysts
<p>In recent years, PAMAM dendrimers have been used as templates for the preparation of supported metal catalysts. This approach takes advantage of several unique characteristics of these dendrimers such as the ability to complex metal cations in solution and to protect them from aggregation until …
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Immobilized liquid membranes for facilitated transport and gas separation
… ILMs was demonstrated with Polyamidoamine (PAMAM) dendrimer as the liquid membrane in its pure form. The pure dendrimer ILMs studied in the present thesis functioned as C02-selective molecular-gate membranes. It was also demonstrated that a judicious use of glycerol as a solvent in dendrimer …
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The Development of a Novel Tumor -Specific MRI Contrast Agent Targeting the High Affinity Folate Receptor: In Vitro and in Vivo Specificity, Toxicity, and Biodistribution
… we present a generation four polyamidoamine (PAMAM) dendrimer conjugated to folic acid that specifically targets the high affinity folate receptor (hFR) overexpressed on more than 80% of ovarian tumors. We tested the hypothesis that folate-dendrimers can specifically image tumors expressing …
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I. Development of novel silicon precursors for rapid and efficient radiofluorination reactions: synthesis and biological evaluation of a 18f-labelled estrogen dendrimer conjugate II. Other studies on 18f-labelled estrogens
… version of 17α-ethynylestradiol conjugated PAMAM dendrimer that can be used for in vivo distribution studies of this novel hormone-polymer conjugate. Through biodistribution studies, we have found that the EDC, a dendrimer-bound estrogen that provides selective cardiovascular protection …
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Surface Tethered PAMAM Dendrimers On Controlled Pore Glass As Color Release Sensors For Phosphates
<p>Poly(amidoamine) dendrimer (PAMAM) are highly branched macromolecules with reactive amine groups in their interior and exterior. PAMAM dendrimers were attached to controlled pore glass (CPG) surfaces in order to create new functionalized surfaces and used as platforms for UV-vis and fluorescent …
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Studies of multicomponent assemblies
… is divided into three major sections (one on dendrimers, one on tripodal metal ligands and one on a research oriented chemistry curricula) with a primary focus on different types of multicomponent assemblies. In the first chapter, a system is described that used a multicomponent assembly of …