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Showing 1 to 5 of 5 for “"PAH1"”.
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Elucidating the Role of Yeast Lipin (PAH1) in Lipid Droplet Biogenesis
… the role of the phosphatidic acid hydrolase (Pah1p) in the biogenesis of lipid droplets in Saccharomyces cerevisiae. Pah1p is an enzyme that converts phosphatidic acid to diacylglycerol, and its absence or elimination of its catalytic activity results in the accumulation of neutral lipids …
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The Regulation of the Phosphatidate Phosphatase Gene <em>PAH1</em> and Its Regulatory Role on Cell Homeostasis
… <em>Saccharomyces cerevisiae</em> gene, <em>PAH1</em>, encodes a phosphatidate (PA) phosphatase that plays a fundamental role in lipid metabolism. PA phosphatases are key enzymes that catalyze the PA dephosphorylation reaction to form diacylglycerides, the first step in the synthesis of …
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The role of the Dgk1 and Pah1 in lipid interconversion on saccharomyces cerevisiae vacuole physiology, homeostasis, protein sorting and fusion
… of the phosphatidic acid (PA) phosphatase gene Pah1, which converts PA in diacylglycerol kinase (DAG), was previously shown to produce a fragmented vacuole phenotype, greatly inhibit fusion and result in the vacuolar protein sorting defect. As such, the impact of the deletion of the …
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The regulation of yeast homotypic vacuole fusion by phosphatidic acid and diacylglycerol
… lipids by the DAG kinase Dgk1 and PA phosphatase Pah1 may be important for vacuole fusion to effectively occur. Pah1 conversion of PA to DAG was shown to be necessary for SNARE priming activity and localization of key protein factors. We found that Sec18, the SNARE chaperone that carries out …
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Novel lipid regulation of vacuolar fusion in saccharomyces cerevisiae
… which are interconverted by the PA phosphatase Pah1 and the DAG kinase Dgk1. Previous work showed DAG acts as a positive regulator of vacuolar fusion and is proposed to reduce the force requirements of vacuolar fusion. I hypothesized that deletion of Dgk1 would lead to enhanced levels of DAG …