Global ETD Search
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Showing 1 to 6 of 6 for “"PAF1 complex"”.
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Investigations into the Role of Paf1 Complex Proteins in Drosophila Ovaries
… protein spools wrapped by DNA in each cell. The complex of DNA and proteins is referred to as chromatin. Chromatin modifications influence the expression of regulatory proteins that control effectors of cellular physiology and metabolism. The outcome of protein function within a cell decides its …
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The Role of the Set1 RNA Polymerase II Interacting Motif (SRIM) in Set1 Recruitment and Histone H3K4 Methylation
… and functions in a multi-subunit protein complex (Set1C) to catalyze H3K4 mono-, di-, and trimethylation. In addition, mis-regulation of Set1 human orthologs such as MLL (1 to 4) or SETD1A/B have been linked to a variety of cancers such as leukemia and early embryonic development defects. …
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Evasion Of Innate Immunity By The Pathogen Coxiella Burnetii
… response. This effector interacts with the PAF1 Complex (PAF1C), a host factor that is highly involved in transcriptional processes and is a target of viral pathogens to counteract the antiviral response. We demonstrate that PAF1C promotes gene expression downstream of various innate immune …
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Regulation of Set1-Mediated Methylation of Dam1
… is mediated by Set1 within the COMPASS complex. Methylation requires prior ubiquitination of histone H2BK123 by the E2-E3 ligases Rad6 and Bre1, as well as the Paf1 transcriptional elongation complex. This regulatory pathway exemplifies cross-talk <em>in trans</em> between …
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Factors That Mediate Expression Of Unique Ggggcc Repeat Expansions In C9orf72-Associated Als/ftd.
… (~25% of the fly genome) and identified the PAF1 complex (PAF1C), an RNAPII-transcription factor, as a suppressor of G4C2-toxicity. Loss of PAF1C reduced RNA and peptide expression from sense-G4C2 and antisense-G2C4 transgenes in Drosophila and in yeast. Importantly, components Paf1 and Leo1 …
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Chromatin Control of the Antiviral Response to Influenza
… modifications serve as scaffolds for protein complexes controlling transcription or co-transcriptional processes, thus impacting gene expression. Histone tail modifications are regulated by multiple, often overlapping pathways in the cell, and as such, present an important regulatory "node" …