Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"PAD4"”.
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Molecular insights into arabidopsis response to Myzus persicae sulzer (green peach aphid)
… studies suggest that the Arabidopsis PAD4 (PHYTOALEXIN DEFICIENT 4) gene modulates the GPA feeding-induced senescence process. Furthermore, in comparison to the wild type plants, GPA growth was higher on pad4 mutant plants, suggesting an important role for PAD4 in plant defense against …
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Kinetic Characterization of the Protein Arginine Deiminase Family: Mechanistic and Inhibition Studies
… is mounting evidence that suggests dysregulated PAD4 activity plays a critical role in the pathogenesis of Rheumatoid Arthritis (RA). RA is an autoimmune disorder characterized by chronic inflammation of the joints. Currently, RA therapeutics are insufficient because they focus on alleviating the …
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Kinetic, Mechanistic, and Inhibition Studies On the Deiminase Family of Enzymes
… shown that the dysregulation of PAD2 as well as PAD4 are involved in a number of diseases including, rheumatoid arthritis, multiple sclerosis, and cancer. AgD is found in plants, viruses, and bacteria where it is involved in energy production, biosynthesis of polyamines, and biofilm formation. …
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The role of citrullination of central nervous system proteins in multiple sclerosis.
… peptidylarginine deiminases (PADs) with PAD2 and PAD4 expressed in the brain. Excess citrullination occurs in MS, with MBP isolated from MS white matter being more highly citrullinated than in healthy control white matter. This thesis aimed to investigate the in vitro expression of PAD2 and PAD4 …
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Identification of Roles for Peptidylarginine Deiminases (PADs) In Models of Nervous System Regeneration, Assessing Capacities of Pharmacological PAD Inhibitor Application
… central nervous system (CNS). Although PAD2 and PAD4 are currently recognised as the main PADs associated with the CNS, less is understood about the role of PAD3, which has been noted to play roles in CNS regeneration in animal models. This thesis aimed to enhance the understanding of PADs and …
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Vitamin D Inhibits Expression of Protein Arginine Deiminase 2 and 4 in Experimental Autoimmune Encephalomoyelitis Model Of Multiple Sclerosis
… arginine deaminases type 2 and 4 (PAD2 and PAD4) have been implicated to play an etiologic role in demyelination and neurodegeneration by catalyzing a post-translational modification of arginine peptide residues to citrulline. The pathogenesis of MS is poorly understood, though vitamin D …
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Understanding the mechanisms of cir1 disease resistance in Arabidopsis thaliana
… the eds1 (enhanced disease susceptibility 1) and pad4 (phytoalexin deficient 4) mutants which regulate the salicylic acid signalling pathway, as well as the coi1 (coronatine-insensitive 1) mutant which functions in the jasmonic acid signalling pathway. The disease resistance profiles of cir1 eds1, …
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Unlocking thePadlock: Elucidation of Protein Arginine Deiminase 4 Function, Activity and Activation Dynamics
… these protein modifying enzymes, in particular, PAD4, due to the increasing evidence linking dysregulated PAD activity to the incidence and severity of Rheumatiod Arthritis (RA) and other human diseases, such as cancer and colitis.
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Transcriptional and functional study of Arabidopsis defence response against Pseudomanas syringae.
… is more susceptible than sid2 and comparable to pad4. It is likely that CBP60g and CBP60h share partially redundant and crucial functions in defense signaling. The cbp60g and cbp60h double mutant was also found to affect both SA-dependent and independent signaling pathways
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Dissection of Regulatory Networks Mediating Resistance and Susceptibility of Arabidopsis thaliana to the Downy Mildew Pathogen Hyaloperonospora parasitica
… associated with defense signal transduction (PAD4, NDR1, NPR1, RAR1). Double mutant combinations of these signal transduction components were analyzed to detect additive or functionally-redundant contributions to RPP7-dependent resistance. Most of the double mutants support an enhanced level …
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Poly(A) Polymerase 1 (PAPS1) influences organ size and pathogen response in Arabidopsis thaliana
… SUSCEPTIBILITY1 (EDS1)/PHYTOALEXIN DEFICIENT4 (PAD4). Immune responses are accompanied by intracellular redox changes. Consistent with this, the redox-status of the chloroplast is altered in paps1-1 mutants. The molecular effects of the paps1-1 mutation were analysed using an RNA sequencing …
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Autoimmune Consequences of Histone Deimination during Neutrophil Activation
… to citrullines by peptidylarginine deiminase IV (PAD4) creating structures that capture or "trap" bacterial pathogens. Neutrophil extracellular traps (NETs), as these structures are known, generate an extracellular complex of deiminated histones and bacterial cell adjuvants. The complex of …