Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"PACAP"”.
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Role of PACAP-ADNP axis in neurodegenerative process
ll neuropeptide PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide) è stato ampiamente studiato per le sue proprietà neuroprotettive nelle malattie neurodegenerative, tra cui la Sclerosi Laterale Amiotrofica (SLA) e la Retinopatia Diabetica (RD). Le mutazioni nel gene che codifica per …
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Neuroprotective effects of PACAP, VIP and NAP against hyperglycaemic retinal damage
… adenylate cyclase activating polypeptide (PACAP), vasoactive intestinal peptide (VIP) and davunetide (NAP) are three pleiotropic related neuropeptides also expressed in the retina. Their protective role has been shown in different retinal injuries, but little is known about the relationship …
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Einfluss der Neurotransmitter PACAP und VIP auf die Aktivität der Mitogen-aktivierten Proteinkinase in Astrozyten
PACAP und VIP sind Neuropeptide, die über mindestens drei gemeinsame Rezeptortypen agieren: PAC1, VPAC1 und VPAC2. <br>Dieser Arbeit liegen Versuche zugrunde, in denen gezeigt werden konnte, dass PACAP und VIP einen antiproliferativen Effekt auf kultivierte Astrogliazellen ausüben. Es ist bekannt, …
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Characterisation of PACAP-responsive receptor pharmacology and expression in cell models and the spinal cord
Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide that is widely expressed and involved in several biological processes, including pain. PACAP exists in two biologically active forms; PACAP-27 and PACAP-38. PACAP is closely related to vasoactive intestinal peptide (VIP) and …
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Integrated Entrainment of the Suprachiasmatic Clock by the Two Neurotransmitters of the Retinohypothalamic Tract, Glutamate and PACAP
The functional interaction between PACAP and Glu was then investigated. PACAP blocked the phase advance normally induced by Glu at late night, while anti-PACAP reagents augmented the Glu-induced phase advance in the SCN slice as well as the light-induced phase advance in vivo. In the early night, …
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Pituitary Adenylate Cyclase -Activating Peptide Signaling in the Mouse Circadian Clock
… pituitary adenylate cyclase-activating peptide (PACAP) in light/glutamate-induced phase resetting of the circadian clock, yet the particulars of this role remain controversial. Mice generated by Lee Eiden and colleagues that do not express PACAP were examined to test the hypothesis that PACAP …
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MELANOPSIN AND PACAP IN INTRINSICALLY PHOTOSENSITIVE RETINAL GANGLION CELLS REGULATE THE DEVELOPMENT OF RETINOFUGAL PROJECTIONS IN MICE
… adenylate cyclase-activating polypeptide (PACAP). These cells project to brain nuclei to mediate a variety of visual behaviors involved in both non-image and image-forming functions, such as circadian photoentrainment and conscious visual perception. ipRGCs have been implicated in a number …
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The role of VIP family members in diabetic retinopathy
… pituitary adenylate cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP) exert a protective effect against retinal injuries, including DR. However, until now, no study has investigated their protective role against the harmful combined effect of both hyperglycemia and …
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Pituitary adenylate cyclase-activating polypeptide regulates excessive alcohol consumption
… adenylate cyclase-activating polypeptide (PACAP), blocks excessive alcohol drinking as well as motivation to drink. On the other hand, the PAC1 antagonist does not significantly affect water intake, saccharin intake, or responding for ethanol in non-selected outbred Wistar rats. In …
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A Preoptic Neurocircuit that Regulates Blood Glucose Homeostasis
… work, we show that activation of avPOA_Vglut2/PACAP neurons results in temperature-independent changes in whole-body changes in fuel usage, from glucose to fatty acids, driven predominantly via insulin signaling defects in skeletal muscle. This metabolic shift is executed via engagement of the …
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Novel signalling pathways resolving the inflammatory response during peripheral nerve regeneration
… pattern and distinct function of VIP and PACAP and their receptors VPAC1, VPAC2 and PAC1 in the peripheral nerve post injury and how signalling through these receptors can act to promote resolution of the inflammatory response. Once macrophages have executed their function, they are …
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Investigating modifiers that can regulate selective vulnerability in mouse models of spinal muscular atrophy
… adenylate cyclase-activating polypeptide (PACAP), seemed to be an exciting potential neuroprotective modifier. PACAP has been shown to be neuroprotective in an array of neurodegenerative diseases but has not yet been investigated in models of SMA. Here, I investigated whether increased …
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Untersuchung zur Proliferation neocorticaler und hippokampaler Neurone in vitro
… hippokampaler Kulturen mit dem Mitoseinhibitor PACAP sank die Gesamtzahl der Neurone bei Zunahme der multipolaren Neurone. Typ 1-Astrozyten lagen sternförmig vor. Die PACAP-Wirkung fand wahrscheinlich über Aktivierung der Proteinkinase C statt. Gabe von CNTF oder KCl führte zu besserer …
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Síntomas parasimpáticos craneales en pacientes con migraña crónica y correlación con biomarcadores
… activador de adenilato ciclasa pituitaria (PACAP). Nuestro grupo de trabajo ha demostrado un aumento en los niveles plasmáticos del marcador parasimpático VIP en pacientes con MC, aunque esta elevación fue menos consistente que la observada para CGRP.
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The role of light signaling on astrocytic morphological plasticity in the adult male rat suprachiasmatic nucleus
… pituitary adenylate cyclase activating peptide (PACAP), have been shown to bind to receptors that activate kinases responsible for GFAP phosphorylation. Based on this work, we hypothesized that the RHT regulates astrocytic cytoskeletal dynamics within the SCN of the male rat. To show this we …
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Investigation of the Signaling Mechanisms of the Pineal Hormone Melatonin in the in Vitro Rat Suprachiasmatic Nucleus
… with several neuromodulators, such as NPY, PACAP, and cAMP. Furthermore, there are at least two different melatonin receptors identified in the rodent SCN, the MT1 and MT2 receptors. Using specific antagonists against the MT2 melatonin receptor, it was determined that the MT2, and not the …
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mRNA EXPRESSION ANALYSIS OF MIDBRAIN DOPAMINE NEURONS IN RESPONSE TO NICOTINE INTAKE DURING MATURATION
… differentially expressed neuroprotective genes (PACAP, LPL and GRP) in the VTA and the SN at different age stages. Our results suggested that only the LPL gene significantly differentially expressed between the VTA and the SN in the 24-month old rats. In addition, nicotine treatment did not show …
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A Molecular Dissection of the Ventromedial Hypothalamic Nucleus
… by real-time PCR, and three genes (Cerebellin 1, PACAP, and a novel gene we characterized, LBH2) were examined by in situ hybridization for further validation and examination of their subnuclear expression profile. One of the VMH markers, steroidogenic factor 1 (SF-1), is an orphan nuclear …