Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"PABPN1"”.
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The Role of the Human Nuclear Poly(A) Binding Protein in RNA Decay
… the ubiquitous nuclear poly(A) binding protein PABPN1. We show that PABPN1 is required for the degradation of a viral nuclear noncoding RNA as well as an inefficiently exported human mRNA. Importantly, the targeting of RNAs to this decay pathway requires the PABPN1 and poly(A) polymerase …
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Molekulargenetische Untersuchungen zur okulopharyngealen Muskeldystrophie
… in the „poly(A) binding protein nuclear1“(PABPN1)-gene was identified to be responsible for the disease. The characteristic mutation is an expansion of a (GCG)6 trinucleotide repeat to a length of (GCG)8-13. An ultrastructural hallmark of OPMD is the presence of intranuclear tubular …
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Post-transcriptional regulation of poly(A) binding proteins direct multiple facets of cardiac development and hypertrophy
… multiple poly(A) binding proteins—PABPC1 and PABPN1—at the 3’UTR and poly(A) tail of cardiac mRNAs to tune transcript specific and overall translation rates within the heart. These findings define a new paradigm for cardiac gene regulation with potential for broader implications across many …
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Régulation du transcriptome codant et non-codant chez Schizosaccharomyces pombe: facteurs et mécanismes impliqués dans la maturation 3’ des ARNs et la terminaison de la transcription
… noyau, la queue poly(A) des ARNms est liée par PABPN1 (poly(A)-binding protein nuclear 1). PABPN1 fut notamment caractérisée, d’après des études in vitro, pour stimuler la réaction de polyadénylation en plus de contrôler la taille ultime des queues poly(A). Cela dit, la ou les fonction(s) …
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Unravelling TERRA regulation by the interplay of two mechanisms: RALY interaction and telomere-specific polyadenylation
… in diverse human cancer cell lines and that PABPN1 is enriched especially at polyadenylated TERRA transcripts. We then investigated polyadenylation as a factor for TERRA stability. The role of the TERRA poly(A) tail is more complex than representing only a stabilizer, as polyadenylation may …