Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"PABP"”.
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The Role of Phosphorylation In Pam2 Motif-Containing Proteins Mediated Messenger Rna Deadenylation
… translation efficiency. Poly(A)-binding protein (PABP), which binds to newly synthesized poly(A) tails homogeneously and is known as a scaffold protein for PAM2 motif-containing proteins, plays a pivotal role in the shortening of poly (A) tails. This study is to examine the role of phosphorylation …
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Utilization of Poly(A)-Binding Protein in Monitoring the Formation of mRNP Granules in Toxoplasma gondii
… I chose to study the poly(A) binding protein (PABP). Metazoans usually encode multiple isoforms of PABP to function in nucleus and/or cytoplasm but in Toxoplasma there is only one predicted PABP. In this thesis, I studied the localization of the only predicted PABP in Toxoplasma (TgPABP). It …
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Identificación y estudio de las interacciones virus-célula del vesivirus de conejo (RaV)
… se pudo estudiar la función de las proteínas PABP y hnRNPK en la infección. La proteína PABP, identificada por su interacción con secuencias próximas al extremo 3’ del genoma del RaV, fue silenciada en cultivos celulares y la posterior infección dio lugar a un descenso en el título viral, lo …
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RNA-binding proteins mediate anti-inflammatory regulation of vascular disease
… significantly increased poly-A-Binding protein (PABP) expression localizing to discrete punctate structures in both vascular smooth muscle (VSMC) and endothelial cells (EC) of the aortic arch of Ldlr-/- mice, as compared to WT controls. EIF2α phosphorylation, requisite for SG formation, was also …
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Human La Function in Expression of Coding Transcripts
… with the cytoplasmic poly(A) binding protein (PABP). During viral infection, tumor progression, and certain forms of cellular stress, the predominantly nuclear hLa protein has been shown to translocate to the cytoplasm where it functions as an IRES trans-acting factor (ITAF), controlling …
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Mechanisms of persistent translation arrest following global brain ischemia and reperfusion
… were found to only colocalize with eIF4G, PABP and HuR, suggesting that mRNA granules may itself be related to or a subset of the ELAV/Hu granule.</p> <p>6. HuR co-localized to mRNA granules and translation of HSP-70. This correlation suggests mRNA granules are involved in …
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Regulating transcript fate through RNA elements in the 3' untranslated region
… of the poly(A) tail, which is then bound by PABP leading to a cascade of interactions resulting in the recruitment of translational machinery. This mechanism is more nuanced than isolating transcripts away from translational machinery, as the length of the poly (A) tail determines how many …
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Régulation du transcriptome codant et non-codant chez Schizosaccharomyces pombe: facteurs et mécanismes impliqués dans la maturation 3’ des ARNs et la terminaison de la transcription
… noyau, la queue poly(A) des ARNms est liée par PABPN1 (poly(A)-binding protein nuclear 1). PABPN1 fut notamment caractérisée, d’après des études in vitro, pour stimuler la réaction de polyadénylation en plus de contrôler la taille ultime des queues poly(A). Cela dit, la ou les fonction(s) …
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Investigating the role of PABPC5 in mouse physiology
Poly(A)-binding proteins (PABPs) are a family of RNA-binding proteins involved in post-transcriptional regulation. In mammals five PABPs have been identified, some widely expressed (e.g., PABP1 and PABP4) while others are limited to specific tissues and developmental time points (e.g., ePABP). The …
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Role of PABP4 in intrauterine growth restriction
… two members of the poly(A)-binding protein (PABP) family of RNAbinding proteins, PABP1 and PABP4, are widely expressed in a range of adult tissues. PABP1, the prototypical family member, has been intensively characterised as central regulator of both global and mRNA-specific translation and …