Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"P815"”.
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The Treatment of Solid Tumours with Complete Freund's Adjuvant
… and found to increase survival in both the P815 mastocytoma and 4T1 mammary cancer models. CFA treatment was not, however, found to be effective in the CT26 colorectal carcinoma and the DEN-induced Hepatocellular carcinoma. Combination therapy with CFA and anti-CTLA-4, which blocks the …
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The Treatment of Solid Tumours with Complete Freund's Adjuvant
… and found to increase survival in both the P815 mastocytoma and 4T1 mammary cancer models. CFA treatment was not, however, found to be effective in the CT26 colorectal carcinoma and the DEN-induced Hepatocellular carcinoma. Combination therapy with CFA and anti-CTLA-4, which blocks the …
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Differentiation and activation of functionally distinct macrophage populations by CSF-1 and GM-CSF
… treatment with IFN-$\gamma$ plus LPS. When P815 tumor targets were used, GM-CSF-derived BMDM displayed higher basal and inducible levels of killing than CSF-1-derived BMDM and required only LPS treatment to reach full cytolytic capacity. Additionally, GM-CSF-derived BMDM showed greater …
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Characterization of a Novel Receptor CS1 in Human Lymphocytes; Studies in Natural Killer Cells and B-Lymphocytes
… was able to mediate redirect cytotoxicity of P815 target cells as well as intracellular calcium influx in the presence of monoclonal antibody against CS1 suggesting that CS1-L is an activating receptor. CS1-S showed no effect on the cytolytic function and calcium influx suggesting that CS1-L …
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Characterizing The Effect of Dasatinib On Anti-Tumor Immune Response and Exploring The Potential of Combining Targeted Therapy and Immunotherapy In A C-Kit Mutant Mastocytoma Model
… study, we show in the c-KIT mutant mastocytoma P815 mouse model that the therapeutic effect of the c-KIT inhibitor dasatinib is substantially dependent on the anti- tumor T cell response. Even though the direct effect of dasatinib on antigen-driven T cell expansion is inhibitory, 3-day dasatinib …
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Tumor Cell Glutathione Metabolism: Therapeutic Implications
… GSH depletion. Vernolepin-mediated cytolysis of P815 cells was dependent upon exogenous cystine, as was GSH synthesis. This dependence upon cystine for cytolysis was not due to a requirement for protein synthesis or GSH synthesis. The formation of H<sub>2</sub>O<sub>2</sub> as a result of …
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The role of topoisomerase II in amsacrine resistance
… 2. Two tissue culture systems (CHO-AA8 cells or P815 cell cycle mutants) were used as models to study the involvement of topoisomerase II in the resistance of non-cycling cells to amsacrine. Plateau-phase CHO-AA8 cells with a GO/Gl DNA content are resistant, to amsacrine and contain fewer DNA …
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Klonierung und Charakterisierung eines polymorphen MHC Kl. I-Moleküls der LEW.1F-Ratte, das präferentiell Va8.2-exprimierende CD8-T-Zellen expandiert
… wurden stabil in L-Zellen, rCD80-transfizierte P815-Zellen und T-Zellhybridomen (THO35/1) exprimiert. Die serologische Charakterisierung mit 19 RT1f-reaktiven Alloantikörpern ergab, daß sich die LEW.1F-Serologie alleine durch Af erklären läßt. In einem Zytotoxizitätstest mit LEW.1F-reaktiven …
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Novel peptide antigens provide insights into the recognition process by T cells
… clone 2C was raised against the Ld-expressing P815 mastocytoma cell line. About twenty years ago, a peptide called p2Ca was identified by acid extraction from BALB/c thymus tissue as a peptide that mediated reactivity between the 2C T cell clone and Ld-expressing target cells. While p2Ca has …