Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"P70S6K"”.
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Yap1 Expression Predicts Sensitivity to Dual Akt/P70S6K Inhibition In Ovarian and Uterine Malignancies
<p><strong>Purpose: </strong>The PI3K/AKT/P70S6K pathway is an attractive therapeutic target in ovarian and uterine malignancies due to its high rate of dysregulation and key roles in tumor growth. Here, we examined the biological effects of MSC2363318A, which is a novel inhibitor of AKT1, AKT3, …
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Inhibition of Free fatty acid-Induced Insulin Resistance by Rosemary Extract: Investigation of the Mechanisms Involved
… extract on the phosphorylation and of JNK, mTOR, P70S6K and AMPK kinases. Our results indicate that palmitate treatment increased the phosphorylation of JNK, mTOR, p70S6K whereas rosemary extract completely abolished this effect. Additionally, rosemary extract increased the phosphorylation of AMPK …
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The Effects of an Acute Bout of Neuromuscular Electrical Stimulation on Anabolic Signaling of the mTORC1 Pathway in Individuals with Chronic Stroke
… for 60 minutes. Phosphorylation of mTOR and p70S6K were analyzed using the SDS-PAGE Western blot technique. Phosphorylation is expressed as the ratio of phosphorylated to total protein content. Data were analyzed using two-way repeated measures analysis of variance. Data are reported as mean …
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The Influence of Chromium Supplementation on the Insulin Pathway, Carcass Traits, and Meat Quality of Feedlot Steers
… phospho- Akt, and ribosomal protein S6 kinase 1 (p70S6K) abundance and glucose transporters (GLUT) 4 and 1 gene expression. Experiment 1 showed an increase in dressing percentage (DP), KPH, and shear force, but a decrease in marbling for Cr400 steers. Final BW, HCW, 12th rib backfat (BF), LMA, …
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The Role of Resveratrol and Sirtuin1 in Skeletal Muscle Under a Nutrient Stress
… (AMPK) vs. growth related Protein 70 S6 Kinase (p70S6K) signalling pathways. However, SIRT1 inhibition increased AMPK activity in both low and normal glucose with corresponding mean reductions in p70S6K in normal glucose conditions. This indicates that perhaps normal SIRT1 activity was required …
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PDGFRalpha Signaling Requirements in the Development of Tissues Derived From Sclerotome and Dermatome
… event, downstream effectors including Akt, p70S6K, and PAK1 are not activated and the cells fail to form Rac-associated membrane ruffles. This is the first in vivo evidence that PI3K driven pathways are required for migration downstream of the PDGFRalpha .
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Genetic Analysis of the PI3K/AKT/mTOR Signaling Pathway
… of three PI3K/AKT/mTOR pathway members: AKT1, p70S6K and 4E-BP1) in a variety of contexts, including under baseline cell growth conditions and in response to treatment with different PI3K/AKT/mTOR pathway inhibitors. Traditional genetic analyses were used to identify pathway activation …
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The SYK tyrosine kinase suppresses autolysosome biogenesis via activation of mTORC1 in pancreatic cancer cell lines
… protein and its upstream kinase p70 S6 kinase (p70S6K) following SYKi treatment in PDAC cell lines. SYK-mediated mTORC1 activation occurs independently of MEK/ERK and PI3K/AKT effector signaling pathways. The mTORC1 complex suppresses lysosome biogenesis and macroautophagy (autophagy). …
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Investigation into the mechanisms responsible for muscle atrophy in cancer cachexia
… weight loss, where a depression of mTOR and p70S6K activation was also observed as weight loss increased.
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Intramuscular Anabolic Signaling and Endocrine Response Following Different Resistance Exercise Protocols In Trained Men
… including mTOR (mammalian target of rapamycin), p70S6k (ribosomal S6 kinase 1), and RPS6 (ribosomal protein S6) were not significantly different between trials. Despite significant differences in markers of muscle damage and the endocrine response following STR and HYP, both protocols appeared to …
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Autophagy and Inflammation During Rickettsial Infection
… and activation of the downstream protein P70S6K, a measurement of mTORC1 activation. Furthermore, treatment with mTOR inhibitors, rapamycin and PP242, which induce autophagy, significantly promoted rickettsial replication in BMMs compared to untreated controls. Additionally, I showed for …
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Impact of Muscle Material Properties on the Hypertrophic Response of Aged Women to Resistance Exercise
… their young counterparts. It was also found that p70S6k phosphorylation is a robust marker that can be used to quantify hypertrophic response to acute resistance exercise. In the second study we investigated the impact of a long-term stretching intervention on the response of aged women to an …
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Carnosic acid against insulin resistance and obesity. Investigating its effects on adipocytes.
… in the activation of mTOR, its downstream target p70S6K, JNK, ERK and Ser307 phosphorylation of IRS-1 were completely blocked while the insulin-stimulated glucose uptake and Akt phosphorylation was restored. In the second study, we show that CA reduced lipid accumulation and increased the …
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The Role of Autophagy In The Sensitivity of Osteosarcoma Cells to Gemcitabine Treatment
… decrease the phosphorylation of AKT, mTOR, p70S6K and PRAS40, suggesting that this signaling pathway is involved in the induction of autophagy by GCB.</p> <p>To test whether autophagy contributes to the resistance of OS cells to GCB, we determined the impact of autophagy inhibition on the …
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Identification of a new tumor suppressor pathway modulating rapamycin sensitivity in colorectal cancer
… functional PP2A complex targeting and inhibiting p70S6K and Myc phosphorylation. Taken together, our data show that PPP2R2B-specific PP2A complex functions as a tumor suppressor and its loss contributes to the deregulated S6K and Myc signaling, leading to growth advantage of CRC. Furthermore, we …
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Synthesis of Novel Cannabinoid Ligands and Their Use as Anti-Glioma and Anti-Inflammatory Agents
… reductions in pMEK1/2, pERK1/2, pAkt, and p-p70S6K with increases in pGSK3B, p53, and cleaved caspases 3 and 9, and PARP. Immunohistochemical studies revealed loss of mitochondrial membrane polarization with release of cytochrome-C, DNA fragmentation and condensation, and alterations in …
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Combating Resistance To Epidermal Growth Factor Recpetor Inhibitors In Triple Negative Breast Cancer
… treatment. Importantly, we have identified p70S6K and p90RSK as kinases directly responsible for eIF4B phosphorylation, such that both molecules need to be inactivated in order for eIF4B phosphorylation to be abrogated. This inactivation correlated with a loss of cell growth and viability …
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Physiological and Biochemical Aspects of Methionine Isomers and Precursors in Broilers
… and had limited effects on activation of p70S6K, a key amino acid signaling protein (P > 0.05). Although dietary Met sources did not change oxidative status of the treated chickens, both L-Met and DL-Met but not DL-HMTBA supplementation decreased the level of acute phase protein serum …
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The Effects of Macronutrient and Energy Availability on Metabolic Responses to Exercise: Implications for Training Adaptation
… from afternoon exercise compared with HCHO. p70S6K activity was higher (P=0.08) at 3-h post-afternoon exercise in HCHO versus HFAT (72.7 ± 51.9 vs 44.7 ± 27 fmol.min-1 mg-1). Data demonstrate 1) that restricting CHO in the post-exercise recovery period has no further modulatory effect on the …
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Identifying the signalling pathway of a novel Myostatin Splice Variant (MSV)
… role in skeletal muscle (rps6, 4EBP1 and p70S6K). Treatment with MSV increased the abundance of Smad 3, Myf5, 4EBP1 and stimulated AKTS⁴⁷³and 4EBP1 phosphorylation. These data provided the foundation for confirmation of these pathways targeted by MSV in C₂C₁₂ myoblasts that stably …
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